Bioimaging agents based on redox-active transition metal complexes

Xue, Shan-Shan; Pan, Yingbo; Pan, Wei; Liu, Shujie; Li, Na; Tang, Bo

doi:10.1039/d2sc02587f

Cited by 19 publications

(10 citation statements)

References 126 publications

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“…fat), or utilization of responsive ("smart") contrast agents which change their response according to the surrounding conditions. [8][9][10][11][12][13][14][15] Alternatively, NMR spectra of different tissues could be acquired in a method called magnetic resonance spectroscopy imaging (MRSI). 16,17 With increasing magnetic fields used in modern scanners, other NMR active nuclei such as 13 C (often hyperpolarized), 17,18 19 F, 23 Na, 31 P can be easily detected by MRI as well.…”

Section: Introductionmentioning

confidence: 99%

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Copper(ii) complexes of cyclams withN-(2,2,2-trifluoroethyl)-aminoalkyl pendant arms as potential probes for¹⁹F magnetic resonance imaging

et al. 2023

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Section: Introductionmentioning

confidence: 99%

“…fat), or utilization of responsive (“smart”) contrast agents which change their response according to the surrounding conditions. 8–15 Alternatively, NMR spectra of different tissues could be acquired in a method called magnetic resonance spectroscopy imaging (MRSI). 16,17…”

Section: Introductionmentioning

confidence: 99%

Copper(ii) complexes of cyclams withN-(2,2,2-trifluoroethyl)-aminoalkyl pendant arms as potential probes for¹⁹F magnetic resonance imaging

et al. 2023

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“…Metal ions are involved in many life processes that commonly involve catalytic centers. 82 The metabolism of mercury (Hg) in living systems can induce oxidative stress; therefore, it is meaningful to detect abnormal changes of ONOO À levels caused by Hg 2+ . Ye's group designed a novel Hg 2+ -activated and NIR-emitting fluorescent molecular agent (15) for ONOO À imaging using a ''dual-key-and-lock'' strategy (Fig.…”

Section: Other Biomarkers As Stimulimentioning

confidence: 99%

Multi-stimuli-responsive molecular fluorescent probes for bioapplications

Xue

Pan

et al. 2023

Chem. Commun.

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“…A wide range of label compounds were designed and prepared, according to different requirements by biologists and biophysicists (Klymchenko, 2023). Such studies included redox-active transition metal-based probes, containing essential metal ions such as iron, manganese, and copper, some of them approved as optical and magnetic resonance imaging agents [Xue et al, 2022].…”

Section: Imaging As a Consequent Progress In The Fieldmentioning

confidence: 99%

Editorial: Specialty grand challenge: Structure, spectroscopy, and imaging

Ferreira

2023

Front. Chem. Biol.

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In the interdisciplinary field of chemical biology, different scientists, generally chemists and biologists, undertake their best efforts to develop advanced methodologies and innovative approaches to address important scientific goals and societal demands. Furthermore, confronting the complexity of problems to be solved and sophisticated systems to be discerned, the partnership of diverse other specialists is demanded, including physicists, spectroscopists, pharmacologists, and physicians. Collectively, their complemented work brings together several areas of research, experimental as well as theoretical, to accomplish higher levels of knowledge about the structural and functional characterization of biological systems. A profound understanding of life and its wide-ranging processes are their final aims.Recently, AlphaFold, a revolutionary artificial intelligence (AI) network, predicted the structures of more than 200 million proteins in a universe of 1 million species, reaching to determine the protein structures of nearly every organism with known protein sequence data. It made it possible to understand the relationships between protein functions and its 3D structures, and the results are now available to scientists in a database (Callaway, 2022). These data can certainly encourage numerous types of studies in the future.A significant example of the structural feature's importance in basic and applied investigations is the development of messenger RNA (mRNA)-based therapeutics (Dammes and Peer, 2020). Since its discovery in the 1960s, improvements in its engineering to express therapeutic proteins or manipulate specific genes' expression have enabled a broad range of applications in intractable diseases, such as severe infections, varied forms of cancer, and genetic diseases, besides new vaccines, and accelerate its clinical translation (Kim, 2022;Qin, Tang, Chen et al., 2022). Because of the unfavorable characteristics of mRNA's, such as large size, instability, immunogenicity, sensitivity to enzymatic degradation by RNases, and limited cellular uptake, many pivotal issues had to be solved during the development of mRNA-based therapeutics. Additionally, a variety of delivery strategies, including nanolipids, exosomes, or polymeric micelles as carriers, was crucial for their wide applicability (Uchida et al., 2020).Moreover, investigations in this chemico-biological field frequently lead to the conception, design, and provision of new molecules capable of interacting efficiently with selected biomolecules, and consequently causing remarkable modifications in their functional behavior. Results can establish new parameters and lead to new drugs that are more efficient, safe, and selective in facing illnesses and syndromes. Significant examples are found in the literature, illustrating important and innovative chemical-biological studies. They include small peptides and large protein effects in Alzheimer's disease (Picone et al., 2022), emergence of bimolecular condensates as attractive targets for drug discovery...

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Bioimaging agents based on redox-active transition metal complexes

Abstract: Detecting the fluctuation and distribution of various bioactive species in biological systems is of great importance in determining diseases at their early stages. Metal complexes-based probes have attracted considerable attention...

Cited by 19 publications

References 126 publications

Copper(ii) complexes of cyclams withN-(2,2,2-trifluoroethyl)-aminoalkyl pendant arms as potential probes for¹⁹F magnetic resonance imaging

Copper(ii) complexes of cyclams withN-(2,2,2-trifluoroethyl)-aminoalkyl pendant arms as potential probes for¹⁹F magnetic resonance imaging

Multi-stimuli-responsive molecular fluorescent probes for bioapplications

Editorial: Specialty grand challenge: Structure, spectroscopy, and imaging

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Bioimaging agents based on redox-active transition metal complexes

Abstract: Detecting the fluctuation and distribution of various bioactive species in biological systems is of great importance in determining diseases at their early stages. Metal complexes-based probes have attracted considerable attention...

Cited by 19 publications

References 126 publications

Copper(ii) complexes of cyclams withN-(2,2,2-trifluoroethyl)-aminoalkyl pendant arms as potential probes for19F magnetic resonance imaging

Copper(ii) complexes of cyclams withN-(2,2,2-trifluoroethyl)-aminoalkyl pendant arms as potential probes for19F magnetic resonance imaging

Multi-stimuli-responsive molecular fluorescent probes for bioapplications

Editorial: Specialty grand challenge: Structure, spectroscopy, and imaging

Contact Info

Product

Resources

About

Copper(ii) complexes of cyclams withN-(2,2,2-trifluoroethyl)-aminoalkyl pendant arms as potential probes for¹⁹F magnetic resonance imaging

Copper(ii) complexes of cyclams withN-(2,2,2-trifluoroethyl)-aminoalkyl pendant arms as potential probes for¹⁹F magnetic resonance imaging