Bioimpedance phase angle indicates catabolism in Type 2 diabetes

Dittmar, Manuela; Reber, Helmut; Kahaly, George J.

doi:10.1111/dme.12710

Cited by 69 publications

(77 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Different from the other parameters used to assess body composition measured by BIA, the PhA is considered to be valid also when the hydration status varies, as in obesity and chronic inflammation [ 19 , 20 , 36 ]. Small PhA was reported in patients with cancer [ 20 ], diabetes [ 21 ], and obesity [ 22 ], possibly because of a reduction in the mass of metabolically active cells [ 37 ]. In addition, the adjunctive effect on cell damage of the inflammatory status, commonly accompanying these conditions, should be considered [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…In disease conditions, including MetS, PhA values are frequently lower than normal since either disease-specific parameters and disease-related inflammatory status may impair PhA [ 19 ]. In this regards, the use of the PhA has been recommended as a prognostic marker of mortality in various chronic diseases [ 20 ], including cancer, and is associated with risk of morbidity in diabetes [ 21 ] and obesity [ 22 ]. As long as we know, data on the risk of morbidity in psoriatic patients and the association between PhA and MetS the clinical setting of the chronic, systemic inflammatory status mutual to both conditions are still lacking.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome

Barrea¹,

Macchia²,

Somma

et al. 2016

J Transl Med

View full text Add to dashboard Cite

BackgroundObesity, metabolic syndrome (MetS), and psoriasis, largely driven by environmental factors, show multiple bidirectional associations, with important metabolic implications in psoriatic patients. Besides body mass index (BMI) as a measure of obesity, data on phase angle (PhA), a direct measure by bioelectrical impedance analysis (BIA), used as a marker of cellular health and a predictor of morbidity and mortality in various diseases, are still lacking in psoriasis. In this case–control, cross-sectional study, we investigated the PhA in 180 pairs of adult psoriatic patients and healthy controls, evaluating also the potential use of the PhA as marker of the clinical severity, the quality of life, and the presence of the MetS in psoriatic patients.MethodsAnthropometric measures, metabolic profile and bioelectrical variables were evaluated. The clinical severity was assessed by standardized psoriasis area and severity index (PASI) score and c-reactive protein (CRP) levels, and the quality of life was evaluated by dermatology life quality index (DLQI). MetS was diagnosed according to Adult Treatment Panel III.ResultsPsoriatic patients presented smaller PhA (p < 0.001) and higher prevalence MetS compared with controls. The PhA was significantly associated with number of parameters of MetS in both groups (p < 0.001). After adjusting for BMI, this association remained significant in psoriatic patients only (p < 0.001). Among psoriatic patients, the PhA was the major index value for the diagnosis of MetS (OR 5.87, 95 % CI 5.07–6.79) and was inversely associated with both PASI score and DLQI, independently of BMI (p < 0.001). At multiple regression analysis, the PhA well predicted the PASI score and DLQI. Based on ROC curves, the most sensitive and specific cutoffs of PhA to predict the highest PASI score and the lowest DQLI were ≤4.8° and ≤4.9°, respectively.ConclusionsWe reported that psoriatic patients presented small PhAs, with a novel association between PhA, clinical severity, quality of life in psoriatic patients, and MetS. Further studies are required to validate the PhA’s prognostic ability in assessing the clinical severity and MetS in psoriatic patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome

Barrea¹,

Macchia²,

Somma

et al. 2016

J Transl Med

View full text Add to dashboard Cite

show abstract

“…20,21 In all these studies, PA is concluded to be an early indicator of malnutrition and correlates well with other standard methods of nutrition evaluation including underwater weighing, 22 isotope dilution, and total body potassium. 23 It is postulated that PA value is readily affected by the subtle alterations of integrity of cell membrane and may reflect even the earliest changes of the nutrition patterns. 24 Therefore, our study adds to the pool of evidence directed to the further research and clinical implementation of malnutrition diagnostics using BIA in HD patients.…”

Section: Discussionmentioning

confidence: 99%

Malnutrition Assessment in Hemodialysis Patients: Role of Bioelectrical Impedance Analysis Phase Angle

Rimševičius

Gincaite

Vicka

et al. 2016

Journal of Renal Nutrition

View full text Add to dashboard Cite

“…PhA is used as an indicator of cellular health in relation to imbalance of cellular water and integrity of the cell membrane [8]. However, the PhA value can be negatively influenced by several clinical diseases, such as malnutrition [9], diabetes [10], human immunodeficiency virus infection (HIV infection) [11], and some types of cancer [12,13]. Healthy individuals show higher values of PhA (higher than 5º), indicating better cellular health and cell membrane integrity compared to malnourished patients [9].…”

Section: Introductionmentioning

confidence: 99%

Phase Angle is Determined by Body Composition and Cardiorespiratory Fitness in Adolescents

et al. 2020

View full text Add to dashboard Cite

The phase angle is used to evaluate nutritional status and is an indicator of cellular health. Cardiorespiratory fitness and body composition are strong indicators of health during adolescence. We aimed to evaluate if body composition and cardiorespiratory fitness have an association with phase angle among adolescents. 203 girls and 220 boys (12.8±1.3 years) were evaluated. Peak height velocity, percentage fat mass, fat-free mass, cardiorespiratory fitness, and phase angle measurements were collected. Linear regression adjusted by peak height velocity was used to verify if predictor variables were associated with phase angle among adolescents. Phase angle showed correlation with fat-free mass (girls: r=0.42 and boys: r=0.37); with percent fat mass (girls: r=0.23); and with cardiorespiratory fitness (boys: r=0.19). Linear regression showed that percentage fat mass (in girls) and cardiorespiratory fitness (in boys) had an effect of 11 and 17% in phase angle, respectively, while fat-free mass had an effect of 22 and 26% in phase angle for girls and boys, respectively. Changes in phase angle seem to be more associated with the percentage fat mass in girls, cardiorespiratory fitness in boys, and fat-free mass in both when controlled by peak height velocity.

show abstract

Bioimpedance phase angle indicates catabolism in Type 2 diabetes

Abstract: The phase angle at 100 kHz is a promising measurement for assessing catabolic state in people with diabetes.

Cited by 69 publications

References 28 publications

Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome

Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome

Malnutrition Assessment in Hemodialysis Patients: Role of Bioelectrical Impedance Analysis Phase Angle

Phase Angle is Determined by Body Composition and Cardiorespiratory Fitness in Adolescents

Contact Info

Product

Resources

About