“…RNA modifications play a key role in regulating cell fate, an important regulator of HCC, in tumorigenesis and disease progression (Han et al, 2018;Pea et al, 2021;Braghini et al, 2022). The m6A, m7G, m5C, m1A, m3C, and ψ RNA modifications dynamically regulate the development of HCC, providing new strategies and possibilities for selecting possible therapeutic targets and investigating precisely directed intervention strategies for future HCC therapy (Tian et al, 2019;Bolatkan et al, 2022;Liu et al, 2022;Ren et al, 2022;Tong et al, 2022;Yu et al, 2022). As the most intensively studied RNA modification, m6A, and its regulators regulate the proliferation, migration, invasion, and EMT processes of HCC cells and are promising targets for HCC therapy (Zhou et al, 2019b;Liu et al, 2020a;Wang et al, 2020b;Zhang et al, 2020c;Qu et al, 2020;Wu et al, 2020;Zhu et al, 2020;Li et al, 2021e;Wei, 2021;Gu et al, 2022;Ren et al, 2022).…”