2019
DOI: 10.21203/rs.2.11120/v1
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Bioinformatics analysis of BUB1 expression and gene regulation network in lung adenocarcinoma

Abstract: Lung adenocarcinoma is the most common type of lung cancer with high morbidity and mortality. Potential mechanisms and therapeutic targets of lung adenocarcinoma need further study. BUB1 (BUB1 mitotic checkpoint serine/threonine kinase) encodes a serine/threonine protein kinase which is critical in the mitosis. It is associated with poor prognosis in multiple cancer types. Oncomine database was used to determine the differential expression of BUB1 in normal and lung adenocarcinoma tissues, while UALCAN was use… Show more

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