Bioinformatics Analysis on Molecular Mechanism of Poria Cocos in Treatment of Jaundice

Abstract

Abstract. Objective: To study the molecular mechanism of P.cocos in the treatment of Jaundice by building molecular networks and comparing canonical pathways. Methods: Target proteins of P.cocos related genes of Jaundice were searched from Pubchem and Gene databases online respectively. Molecular networks and canonical pathways comparison analyses were performed by IPA. Results: The molecular networks of P.cocos and Jaundice were complex and multifunctional. The 14 target proteins of P.cocos and 33 Homo sapiens genes of Jaundice were found in databases. There were 56 common pathways both related networks. P.cocos could regulate endothelial differentiation Tumor Necrosis Factor (TNF), Interleukin-1β (IL-1β) and Interleukin-6 (IL-6) in these pathways. Conclusions: P.cocos treat Jaundice by regulatingmany effective nodes of Metabolism pathway and Immunity related pathways.