Bioinformatics approach to analyse COVID-19 biomarkers accountable for generation of intracranial aneurysm in COVID-19 patients

Snigdha, Mahajabin; Akter, Azifa; Amin, Md. Al; Islam, Md Zahidul

doi:10.1016/j.imu.2023.101247

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Genes/proteins Identified By 1-l Transcription Of C-(aa)n-n ...1

Genes/proteins Known To Be Related To Covid-191

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2024

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(2 citation statements)

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“…HSP90 is essential for SARS-CoV-2 viral replication [13,90]. Human coronaviruses activate and hijack the proteostasis guardian HSF1 to enhance viral replication [91], and FILIP1L is downregulated in COVID-19 [92].…”

Section: Genes/proteins Identified By 1-l Transcription Of C-(aa)n-n ...mentioning

confidence: 99%

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1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit

Nahalka

2024

IJMS

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The COVID-19 pandemic prompted rapid research on SARS-CoV-2 pathogenicity. Consequently, new data can be used to advance the molecular understanding of SARS-CoV-2 infection. The present bioinformatics study discusses the “spikeopathy” at the molecular level and focuses on the possible post-transcriptional regulation of the SARS-CoV-2 spike protein S1 subunit in the host cell/tissue. A theoretical protein–RNA recognition code was used to check the compatibility of the SARS-CoV-2 spike protein S1 subunit with mRNAs in the human transcriptome (1-L transcription). The principle for this method is elucidated on the defined RNA binding protein GEMIN5 (gem nuclear organelle-associated protein 5) and RNU2-1 (U2 spliceosomal RNA). Using the method described here, it was shown that 45% of the genes/proteins identified by 1-L transcription of the SARS-CoV-2 spike protein S1 subunit are directly linked to COVID-19, 39% are indirectly linked to COVID-19, and 16% cannot currently be associated with COVID-19. The identified genes/proteins are associated with stroke, diabetes, and cardiac injury.

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Section: Genes/proteins Identified By 1-l Transcription Of C-(aa)n-n ...mentioning

confidence: 99%

“…Human coronaviruses can activate and hijack the proteostasis guardian HSF1 to enhance viral replication [91]. SARS-CoV-2 achieves this by suppressing FILIP1L [92], a regulator of HSF1 [88]. GAS2 can promote cell senescence [93].…”

Section: Genes/proteins Known To Be Related To Covid-19mentioning

confidence: 99%

1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit

Nahalka

2024

IJMS

View full text Add to dashboard Cite

show abstract

Bioinformatics approach to analyse COVID-19 biomarkers accountable for generation of intracranial aneurysm in COVID-19 patients

Cited by 1 publication

References 71 publications

1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit

1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit

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