Bioinformatics-Based Approach for Exploring the Immune Cell Infiltration Patterns in Alzheimer’s Disease and Determining the Intervention Mechanism of Liuwei Dihuang Pill

Zhao, Chenling; Jiang, Zhangsheng; Tian, Lihong; Tang, Lulu; Zhou, An

doi:10.1177/15593258221115563

Cited by 3 publications

(2 citation statements)

References 68 publications

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“…30 However, the specific molecular mechanisms of its action have not been fully understood. Zhao et al 31 used bioinformatics methods to explore the molecular immune mechanism of Liuwei Dihuang Pill in the treatment of AD by studying the infiltration patterns of different types of immune cells in AD. The study found that in hippocampal tissue samples from AD patients, the infiltration levels of M2 macrophages and quiescent CD4þ memory T cells were higher compared to healthy individuals, and there were significant differences in the infiltration levels of M1 macrophages as well.…”

Section: The Application Of Bioinformatics In the Study Of Chinese He...mentioning

confidence: 99%

The Research Progress of the Application of Bioinformatics in the Diagnosis and Treatment of Alzheimer's Disease

Yu,

Wang,

Qiao

et al. 2024

Chinese medicine and natural products

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Alzheimer's disease (AD) is characterized by a complex pathogenesis, limited diagnostic methods, and a lack of effective therapeutic drugs in clinical settings, posing significant challenges in modern medical research. Bioinformatics offers new perspectives for identifying key pathological biomarkers of AD, analyzing differentially expressed genes in AD, screening for effective drug targets against AD, studying the mechanisms of AD pathogenesis, and discovering novel anti-AD drugs. However, data preprocessing and statistical analysis methods in bioinformatics research can significantly impact results, and there is a lack of consistency and coordination in analysis methods across platforms and laboratories in practical studies, making it difficult to compare data between studies. Therefore, it is crucial to establish standardized operating procedures and quality control protocols, improve the reproducibility of methods across platforms, and promote data comparison between studies.

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Section: The Application Of Bioinformatics In the Study Of Chinese He...mentioning

confidence: 99%

The Research Progress of the Application of Bioinformatics in the Diagnosis and Treatment of Alzheimer's Disease

Yu,

Wang,

Qiao

et al. 2024

Chinese medicine and natural products

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“…The pharmacodynamic material basis of the compound cannot be clarified by focusing only on the components of traditional Chinese medicine contained in the compound or the ingredients with pharmacological activity in vitro. Therefore, there are serious methodological defects in the material basis research of LWDHP based on TCM database (such as TCM systematic pharmacology database and analysis platform TCMSP), which usually results in highly homogeneous research results [22][23][24].The pharmacochemistry of TCM serum is an effective method to study the pharmacochemistry and compatibility of the compound. The prototype components of LWDHP in serum and cerebrospinal fluid of SD rats were detected after intragastric administration of 3 mL LWDHP solution (6.75 g/kg).…”

Section: Materials Basis Of Lwdhpmentioning

confidence: 99%

Liuwei Dihuang Pills in the Treatment of Senile Dementia: A Review

2023

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Objective To elucidate the synergistic mechanism of Liuwei Dihuang Pills (LWDHP), with multi-components, multi-targets and multi-channels in the treatment of senile dementia. Methods We searched Chinese and English databases to obtain the blood components of LWDHP, its clinical and preclinical mechanism research progress in the treatment of senile dementia. Based on the network pharmacology of the key pathophysiological process of Alzheimer’s disease (AD), we screened the anti-AD target of LWDHP and its blood components. Results The therapeutic effect of LWDHP on senile dementia is accurate, with few adverse reactions. Its mechanism includes regulation of cholinergic system, autophagy, cerebral microvascular function, neuron apoptosis, insulin signal transduction pathway, etc. In this review, 35 blood components of LWDHP based on HPLC were collected, and their drug toxicity and safety were evaluated. The network pharmacology analysis based on the pathophysiological process of AD shows that the key components of LWDHP in the treatment of AD are Alisol A monoacetate, Linoleic acid, Alisol F, Tumulosic acid, Methyl eugenol, Palmitic acid and Pachymic acid. Conclusion This article summarizes 35 blood components of LWDHP, summarizes the synergistic mechanism of LWDHP in the treatment of senile dementia, uses network pharmacology to provide a series of potential lead compounds for the development of senile dementia’s drugs, and provides a theoretical basis for further expanding the clinical application of LWDHP.

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Associations between the multitrajectory neuroplasticity of neuronavigated rTMS‐mediated angular gyrus networks and brain gene expression in AD spectrum patients with sleep disorders

Yao,

Hou,

Zhou

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONThe multifactorial influence of repetitive transcranial magnetic stimulation (rTMS) on neuroplasticity in neural networks is associated with improvements in cognitive dysfunction and sleep disorders. The mechanisms of rTMS and the transcriptional‐neuronal correlation in Alzheimer's disease (AD) patients with sleep disorders have not been fully elucidated.METHODSForty‐six elderly participants with cognitive impairment (23 patients with low sleep quality and 23 patients with high sleep quality) underwent 4‐week periods of neuronavigated rTMS of the angular gyrus and neuroimaging tests, and gene expression data for six post mortem brains were collected from another database. Transcription‐neuroimaging association analysis was used to evaluate the effects on cognitive dysfunction and the underlying biological mechanisms involved.RESULTSDistinct variable neuroplasticity in the anterior and posterior angular gyrus networks was detected in the low sleep quality group. These interactions were associated with multiple gene pathways, and the comprehensive effects were associated with improvements in episodic memory.DISCUSSIONMultitrajectory neuroplasticity is associated with complex biological mechanisms in AD‐spectrum patients with sleep disorders.Highlights This was the first transcription‐neuroimaging study to demonstrate that multitrajectory neuroplasticity in neural circuits was induced via neuronavigated rTMS, which was associated with complex gene expression in AD‐spectrum patients with sleep disorders. The interactions between sleep quality and neuronavigated rTMS were coupled with multiple gene pathways and improvements in episodic memory. The present strategy for integrating neuroimaging, rTMS intervention, and genetic data provide a new approach to comprehending the biological mechanisms involved in AD.

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Bioinformatics-Based Approach for Exploring the Immune Cell Infiltration Patterns in Alzheimer’s Disease and Determining the Intervention Mechanism of Liuwei Dihuang Pill

Cited by 3 publications

References 68 publications

The Research Progress of the Application of Bioinformatics in the Diagnosis and Treatment of Alzheimer's Disease

The Research Progress of the Application of Bioinformatics in the Diagnosis and Treatment of Alzheimer's Disease

Liuwei Dihuang Pills in the Treatment of Senile Dementia: A Review

Associations between the multitrajectory neuroplasticity of neuronavigated rTMS‐mediated angular gyrus networks and brain gene expression in AD spectrum patients with sleep disorders

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