Bioinformatics in Sudan: Status and challenges case study: The National University-Sudan

Abstract

The ever increasing applications of bioinformatics in providing effective interpretation of large and complex biological data require expertise in the use of sophisticated computational tools and advanced statistical tests, skills that are mostly lacking in the Sudanese research community. This can be attributed to paucity in the development and promotion of bioinformatics, lack of senior bioinformaticians, and the general status quo of inadequate research funding in Sudan. In this paper, we describe the challenges that have encountered the development of bioinformatics as a discipline in Sudan. Additionally, we highlight on specific actions that may help develop and promote its education and training. The paper takes the National University Biomedical Research Institute (NUBRI) as an example of an institute that has tackled many of these challenges and strives to drive powerful efforts in the development of bioinformatics in the country.

Bioinformatics analysis of the potential regulatory mechanisms of renal fibrosis and the screening and identification of factors related to human renal fibrosis

“…Previous studies (26)(27)(28) have shown that integrin alpha V (AV) stimulates the proliferation and activation of renal fibroblasts through TGF signaling, thereby promoting fibrosis (29). The loss of integrin AV has been shown to protect against renal fibrosis in a unilateral ureteral obstruction (UUO), and thus, integrin AV intervention is a key factor in the treatment of CKD characterized by renal fibrosis (30). Also, MF was found to be related to phospholipid binding.…”