Bioinspired 3D scaffolds with antimicrobial, drug delivery, and osteogenic functions for bone regeneration

Atkinson, Irina; Seciu-Grama, Ana-Maria; Serafim, Andrada; Petrescu, Simona; Voicescu, Mariana; Anghel, Elena Maria; Marinescu, Cornelia; Mitran, Raul Augustin; Mocioiu, Oana Catalina; Cusu, Jeanina Pandele; Lincu, Daniel; Prelipcean, Ana-Maria; Craciunescu, Oana

doi:10.1007/s13346-023-01448-y

Cited by 1 publication

(1 citation statement)

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“…To fabricate bone tissue engineering scaffolds, mesoporous bioactive glass (MBG) has gained much attention due to its abilities of high drug loading and inducing bone-like apatite deposition ( Zhu et al, 2015b ; Feng et al, 2023 ; Yang et al, 2023 ). Furthermore, combining MBG with biodegradable polymers to form composite scaffolds can enhance mechanical strength and regulate biological properties of the scaffolds ( Atkinson et al, 2022 ; Shi et al, 2022 ; Atkinson et al, 2023 ; Ma et al, 2023 ; Sanchez-Salcedo et al, 2023 ). For example, Wu et al demonstrated the enhanced osteogenic ability and mechanical strength by loading dexamethasone into the 3D printed MBG scaffolds with poly(vinyl alcohol) as a binder ( Wu et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Dimethyloxallyl glycine-loaded mesoporous bioactive glass/poly(D,L-lactide) composite scaffolds with ultrasound stimulation for promoting bone repair

Han,

Zhao,

Zhu

et al. 2024

Front. Bioeng. Biotechnol.

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Introduction: Bone tissue engineering is considered the ideal approach for bone repair. Mesoporous bioactive glass (MBG) possesses the characteristics of high drug-loading capacity and bioactivity. Low-intensity pulsed ultrasound contributes to promoting fracture healing and bone defect repair, and dimethyloxalyl glycine (DMOG) is a small molecular inhibitor that can suppress prolyl hydroxylase, reducing the degradation of hypoxia-inducible factor.Methods: In this study, we proposed to prepare DMOG-loaded MBG/poly(D,L-lactide) composite scaffolds (DMOG-MBG/PDLLA) for promoting bone repair. The effects of ultrasound stimulation and DMOG release on the cell responses of rat bone marrow mesenchymal stem cells (BMSCs) and human umbilical vein endothelial cells (HUVECs) and bone repair in vivo were investigated.Results and Discussion: The results showed that both ultrasound stimulation and DMOG release could promote the proliferation, adhesion and differentiation of BMSCs and HUVECs, respectively. After the implantation of scaffolds in rat cranial bone defect model for 8 weeks, the results indicated that the combined ultrasound stimulation and DMOG release contributed to the highest ability for promoting bone repair. Hence, the DMOG-MBG/PDLLA scaffolds with ultrasound stimulation are promising for application in bone repair.

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