Bioinspired surface modification of orthopedic implants for bone tissue engineering

Hu, Chaoquan; Ashok, Deepu; Nisbet, David R.; Gautam, Vini

doi:10.1016/j.biomaterials.2019.119366

Cited by 236 publications

(146 citation statements)

References 305 publications

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“…The biomineral medium of bone contains about 30% organic and 70% inorganic segments . Almost, 90% of this organic segment is collagen, whereas the residual 10% was mostly non-collagenous proteins, lipids, proteoglycan molecules, osteopontin (OPN), and other bone matrix proteins (Hu et al 2019). The bone matrix proteins play vital role in mechanical strength and tissue adhesive characteristics.…”

Section: Bone Cells and Matrixmentioning

confidence: 99%

Bone tissue regeneration: biology, strategies and interface studies

2019

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Nowadays, bone diseases and defects as a result of trauma, cancers, infections and degenerative and inflammatory conditions are increasing. Consequently, bone repair and replacement have been developed with improvement of orthopedic technologies and biomaterials of superior properties. This review paper is intended to sum up and discuss the most relevant studies performed in the field of bone biology and bone regeneration approaches. Therefore, the bone tissue regeneration was investigated by synthetic substitutes, scaffolds incorporating active molecules, nanomedicine, cell-based products, biomimetic fibrous and nonfibrous substitutes, biomaterial-based three-dimensional (3D) cell-printing substitutes, bioactive porous polymer/inorganic composites, magnetic field and nano-scaffolds with stem cells and bone-biomaterials interface studies.

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Section: Bone Cells and Matrixmentioning

confidence: 99%

Bone tissue regeneration: biology, strategies and interface studies

2019

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“…Surface modifications with patterns at both micro- and nanorange have also demonstrated the ability to influence the commitment of MSCs towards a selected cell lineage [ 112 ]. This is of particular relevance for BTE applications since, by engineering implants with surface modifications (i.e., surface roughness or micro/nanopatterns), it will be possible to control the interaction between the scaffold and the host tissue [ 113 ].…”

Section: The Effect Of Substrate Topographymentioning

confidence: 99%

Topography: A Biophysical Approach to Direct the Fate of Mesenchymal Stem Cells in Tissue Engineering Applications

Cun

Hosta‐Rigau

2020

Nanomaterials

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Tissue engineering is a promising strategy to treat tissue and organ loss or damage caused by injury or disease. During the past two decades, mesenchymal stem cells (MSCs) have attracted a tremendous amount of interest in tissue engineering due to their multipotency and self-renewal ability. MSCs are also the most multipotent stem cells in the human adult body. However, the application of MSCs in tissue engineering is relatively limited because it is difficult to guide their differentiation toward a specific cell lineage by using traditional biochemical factors. Besides biochemical factors, the differentiation of MSCs also influenced by biophysical cues. To this end, much effort has been devoted to directing the cell lineage decisions of MSCs through adjusting the biophysical properties of biomaterials. The surface topography of the biomaterial-based scaffold can modulate the proliferation and differentiation of MSCs. Presently, the development of micro- and nano-fabrication techniques has made it possible to control the surface topography of the scaffold precisely. In this review, we highlight and discuss how the main topographical features (i.e., roughness, patterns, and porosity) are an efficient approach to control the fate of MSCs and the application of topography in tissue engineering.

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“…State-of-the-art investigations of orthopedic and dental implants are focused on bone-inspired surface modification [ 1 , 2 , 3 , 4 ]. The success of implantation, which is complex and time-consuming process, depends greatly on osseointegration [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

A New Insight into Coating’s Formation Mechanism Between TiO2 and Alendronate on Titanium Dental Implant

et al. 2020

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Organophosphorus compounds, like bisphosphonates, drugs for treatment and prevention of bone diseases, have been successfully applied in recent years as bioactive and osseoinductive coatings on dental implants. An integrated experimental-theoretical approach was utilized in this study to clarify the mechanism of bisphosphonate-based coating formation on dental implant surfaces. Experimental validation of the alendronate coating formation on the titanium dental implant surface was carried out by X-ray photoelectron spectroscopy and contact angle measurements. Detailed theoretical simulations of all probable molecular implant surface/alendronate interactions were performed employing quantum chemical calculations at the density functional theory level. The calculated Gibbs free energies of (TiO2)10–alendronate interaction indicate a more spontaneous exergonic process when alendronate molecules interact directly with the titanium surface via two strong bonds, Ti–N and Ti–O, through simultaneous participation common to both phosphonate and amine branches. Additionally, the stability of the alendronate-modified implant during 7 day-immersion in a simulated saliva solution has been investigated by using electrochemical impedance spectroscopy. The alendronate coating was stable during immersion in the artificial saliva solution and acted as an additional barrier on the implant with overall resistivity, R ~ 5.9 MΩ cm2.

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Bioinspired surface modification of orthopedic implants for bone tissue engineering

Cited by 236 publications

References 305 publications

Bone tissue regeneration: biology, strategies and interface studies

Bone tissue regeneration: biology, strategies and interface studies

Topography: A Biophysical Approach to Direct the Fate of Mesenchymal Stem Cells in Tissue Engineering Applications

A New Insight into Coating’s Formation Mechanism Between TiO2 and Alendronate on Titanium Dental Implant

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