Biointerfacing and Applications of Cell Membrane-Coated Nanoparticles

Kroll, Ashley V.; Fang, Ronnie H.; Zhang, Liangfang

doi:10.1021/acs.bioconjchem.6b00569

Cited by 307 publications

(246 citation statements)

References 90 publications

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“…More recently, the cell membrane has been exploited to coat various NPs. 285 This strategy provides new inspirations for enhancing blood circulation time. The development of new materials to significantly increase tumour accumulation will be of great importance.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

et al. 2017

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Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared with normal tissue, the tumour microenvironment has some unique properties, such as vascular abnormalities, hypoxia and acidic pH. There are many types of cells including tumour cells, macrophages, immune and fibroblasts cells, fed by defective blood vessels in the solid tumour. Exploiting the tumour microenvironment can benefit the design of nanoparticles for enhanced therapeutic effectiveness. In this review article, we summarized the recent progress in various nanoformulations for cancer therapy, with special emphasis on tumour microenvironment stimuli-responsive ones. Numerous tumour microenvironment modulation strategies with promising cancer therapeutic efficacy have also been highlighted. Future challenges and opportunities of design consideration are also discussed in details. We believe that these tumour microenvironment modulation strategies offer a good chance for the practical translation of nanoparticle formulas into clinic.

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Section: Conclusion and Perspectivementioning

confidence: 99%

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

et al. 2017

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“…Many technologies that have been adopted in the modern world were adapted from nature, and many of these are employed on a daily basis . Likewise, biomimetic design principles have become increasingly prevalent within the field of nanomedicine, where the result is a streamlined approach for fabricating multifunctional nanoparticle platforms that can effectively interface with biological systems …”

Section: Biomimetic Nanoparticle Technologymentioning

confidence: 99%

“…Most virulence factors must in some way interact with cells via the plasma membrane in order to exert their toxicity . To leverage this fact, cell membrane–coated nanoparticles have been used as decoys that are capable of neutralizing toxins and preventing them from harming healthy cells . This concept was first demonstrated using red blood cell (RBC) membrane–coated nanoparticles (RBC‐NPs) as a means of guarding against the activity of hemolytic toxins ( Figure ) .…”

Section: Biomimetic Antibacterial Nanovaccinesmentioning

confidence: 99%

Biomimetic Nanotechnology toward Personalized Vaccines

et al. 2019

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While traditional approaches for disease management in the era of modern medicine have saved countless lives and enhanced patient well‐being, it is clear that there is significant room to improve upon the current status quo. For infectious diseases, the steady rise of antibiotic resistance has resulted in super pathogens that do not respond to most approved drugs. In the field of cancer treatment, the idea of a cure‐all silver bullet has long been abandoned. As a result of the challenges facing current treatment and prevention paradigms in the clinic, there is an increasing push for personalized therapeutics, where plans for medical care are established on a patient‐by‐patient basis. Along these lines, vaccines, both against bacteria and tumors, are a clinical modality that could benefit significantly from personalization. Effective vaccination strategies could help to address many challenging disease conditions, but current vaccines are limited by factors such as a lack of potency and antigenic breadth. Recently, researchers have turned toward the use of biomimetic nanotechnology as a means of addressing these hurdles. Recent progress in the development of biomimetic nanovaccines for antibacterial and anticancer applications is discussed, with an emphasis on their potential for personalized medicine.

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“…These particles exhibited significantly enhanced circulation, which was shown to result from the preservation of RBC self-markers such as CD47 on the nanoparticle surface in a right-side-out orientation [207–209]. Afterwards, a plethora of different platforms have been reported given the flexibility of choosing different membrane materials and different nanoparticle cores [210–213]. These have been employed for a variety of applications, some of which uniquely take advantage of their biomimetic properties (Fig.…”

Section: Cell Membrane-based Nanostructuresmentioning

confidence: 99%

Cell membrane-derived nanomaterials for biomedical applications

et al. 2017

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The continued evolution of biomedical nanotechnology has enabled clinicians to better detect, prevent, manage, and treat human disease. In order to further push the limits of nanoparticle performance and functionality, there has recently been a paradigm shift towards biomimetic design strategies. By taking inspiration from nature, the goal is to create next-generation nanoparticle platforms that can more effectively navigate and interact with the incredibly complex biological systems that exist within the body. Of great interest are cellular membranes, which play essential roles in biointerfacing, self-identification, signal transduction, and compartmentalization. In this review, we explore the major ways in which researchers have directly leveraged cell membrane-derived biomaterials for the fabrication of novel nanotherapeutics and nanodiagnostics. Such emerging technologies have the potential to significantly advance the field of nanomedicine, helping to improve upon traditional modalities while also enabling novel applications.

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Biointerfacing and Applications of Cell Membrane-Coated Nanoparticles

Cited by 307 publications

References 90 publications

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

Biomimetic Nanotechnology toward Personalized Vaccines

Cell membrane-derived nanomaterials for biomedical applications

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