Biolimus-eluting vs. other limus-eluting stents in NSTE-ACS: A pooled analysis of GLASSY and TWILIGHT

Spirito, Alessandro; Valgimigli, Marco; Cao, Davide; Baber, Usman; Mehta, Shamir R.; Gibson, C. Michael; Steg, Gabriel; Sharma, Samin K.; Goel, Ridhima; Huber, Kurt; Kunadian, Vijay; Escaned, Javier; Franzone, Anna; Han, Yaling; Collier, Timothy J.; Kaul, Upendra; Kornowski, Ran; Krucoff, Mitchell W.; Moliterno, David J.; Sartori, Samantha; Owen, Ruth; Zhang, Zhongjie; Dangas, George; Kastrati, Adnan; Angiolillo, Dominick J.; Cohen, David J.; Vranckx, Pascal; Windecker, Stephan; Pocock, Stuart J.; Mehran, Roxana

doi:10.1016/j.ijcard.2023.04.027

International Journal of Cardiology

2023

DOI: 10.1016/j.ijcard.2023.04.027

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Biolimus-eluting vs. other limus-eluting stents in NSTE-ACS: A pooled analysis of GLASSY and TWILIGHT

Alessandro Spirito

Marco Valgimigli

Davide Cao

et al.

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Cited by 2 publications

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Polymer free biolimus coated stents to treat acute ST‐elevation myocardial infarction in Asian patients

Ong,

Chui,

Tam

et al. 2024

Cathet Cardio Intervent

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BackgroundPatients undergoing primary percutaneous coronary intervention (PPCI) for ST‐segment‐elevation myocardial infarction (STEMI) have a high thrombotic burden and often have a high bleeding risk (HBR). Asian patients have different patterns of thrombotic and bleeding risk from other populations which may be particularly relevant in the setting of PPCI for STEMI.ObjectivesTo assess the safety and efficacy of the polymer free biolimus coated coronary stent (PF‐BCS, BioFreedomTM, Biosensors International) in Asian STEMI patients.MethodsPatients with acute STEMI who received at least one PF‐BCS were invited to participate after their index procedure. Follow‐up was performed at 1, 4, and 12 months. The primary endpoint was the rate of target lesion failure (TLF) at 1 year. A performance goal was derived from the biolimus eluting stent arm of the COMFORTABLE AMI study which was the only prior dedicated study of biolimus eluting stents in patients with STEMI.ResultsA total of 914 patients with STEMI were enrolled. Mean patient age was 60 ± 13 years, diabetes was present in 23.2% and 43% were active smokers. According to the ARC definition, 12.4% of the patients were HBR. TLF rate was 2.54% [95% CI: 1.52–3.56], p‐value for non‐inferiority <0.0001, p‐value for superiority = 0.0004). The rate of definite/probable stent thrombosis was 0.44% [95% CI: 0.16–1.16]. There was a trend toward more BARC 3 to 5 bleeding in ARC‐HBR patients (3.69% vs 1.46%, HR = 2.74, [95% CI: 0.87–8.62], p = 0.07).ConclusionsIn Asian patients undergoing PPCI for STEMI and treated with variable durations of DAPT, the use of a PF‐BCS was associated with low rates of TLF and stent thrombosis (NCT03609346).

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Polymer free biolimus coated stents to treat acute ST‐elevation myocardial infarction in Asian patients

Ong,

Chui,

Tam

et al. 2024

Cathet Cardio Intervent

View full text Add to dashboard Cite

show abstract

Seeking precision in percutaneous coronary revascularization: The best stent for each setting

Avanzas

Torre

2023

International Journal of Cardiology

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Biolimus-eluting vs. other limus-eluting stents in NSTE-ACS: A pooled analysis of GLASSY and TWILIGHT

Cited by 2 publications

References 26 publications

Polymer free biolimus coated stents to treat acute ST‐elevation myocardial infarction in Asian patients

Polymer free biolimus coated stents to treat acute ST‐elevation myocardial infarction in Asian patients

Seeking precision in percutaneous coronary revascularization: The best stent for each setting

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