Biologic markers in ethylene oxide-exposed workers and controls

Mayer, Jack; Warburton, Dorothy; Am, Jeffrey; Pero, Ronald W.; Walles, Solveig; Andrews, Leslie; Toor, M.; Latriano, Louise; Wazneh, Leila; Tang, Deliang

doi:10.1016/0027-5107(91)90098-9

Cited by 66 publications

(22 citation statements)

References 34 publications

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“…These findings are consistent with some, but not all, results of recent studies of low-level EO exposure (15)(16)(17)(18). However, the number of currently exposed workers in the project (n = 11) is too small to exclude with confidence the possibility of a link between current exposure levels and genotoxicologic effects.…”

Section: Resultssupporting

confidence: 90%

“…Given that there was no evidence of an interaction when all workers were included in the analyses, even though the current workers also had past exposures, it is hard to conclude that this is a biologically important interaction. No interactions were observed for the genetic variables in the study of Mayer and co-workers (15).…”

Section: Resultsmentioning

confidence: 77%

“…EO-hemoglobin adducts, but not with micronuclei, chromosomal aberratons, single-strand DNA breaks, or an index of DNA repair (15). However, the effect of EO Discussion exposure on SCE was statistically significant only in an analysis of variance where smokers and quitters were Studies in the past have demonstrated that EO expo-combined, even though quitters were not found to be sures of TWA greater than 5 ppm result in increased statistically different from lifetime nonsmokers.…”

Section: Resultsmentioning

confidence: 80%

“…The analysis of these high-frequency cells (HFC) has become an important adjunct to the study of SCE (20,21), particularly in the case of EO exposure in man (15,22). As SCEs have proven to be sensitive to fairly low EO levels, persistent after higher exposures, relatively easy to score, and to have low interobserver variability, SCE analysis was chosen for investigation of genotoxicity in the entire cohort.…”

Section: Genetic Testsmentioning

confidence: 99%

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A Study of Sister Chromatid Exchange and Somatic Cell Mutation in Hospital Workers Exposed to Ethylene Oxide

Tomkins¹,

Haines²,

Lawrence³

et al. 1993

Environmental Health Perspectives

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To investigate the risks of exposure to ethylene oxide (EO) at current permissible levels and at past higher levels, an inception cohort of sterilizer operators and supervisors from the Central Processing Department (CPD), respiratory therapists, and engineers exposed to EO were identified at the McMaster University Medical Centre. A comparison group from Nutrition Services (NUTR) were matched with the CPD workers on the basis of sex, age, and smoking habit. The present report is based on genetic test results for the 94 CPD and matched NUTR workers only. Statistical analysis based on the mean SCE frequency in the top 5, top 10, and all cells (50 cells scored per individual) and high frequency cells (HFC) based on the 95th percentile for nonsmoking control subjects showed a direct association with current smoking but not with EO exposure. Similarly, statistical analysis of the somatic cell mutation (SCMT) variant frequencies did not demonstrate an association with EO exposure, nor with smoking. Regression analysis indicated that sex was the only other covariate that significantly affected SCE. Age was weakly associated with SCMT. A statistically significant interaction between occupational exposure and smoking habits was observed only for the mean SCE frequency of the top 5 and top 10 cells when the 11 current CPD/NUTR pairs were not included. Thus, this interaction should be interpreted with caution.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 80%

Section: Genetic Testsmentioning

confidence: 99%

See 2 more Smart Citations

A Study of Sister Chromatid Exchange and Somatic Cell Mutation in Hospital Workers Exposed to Ethylene Oxide

Tomkins¹,

Haines²,

Lawrence³

et al. 1993

Environmental Health Perspectives

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“…In humans haemoglobin adducts with histidine and the N-terminal valine have been detected after exposure to ethylene oxide (5,33,11,20,16,17,23,29).…”

Section: Selection Of the Indicatorsmentioning

confidence: 99%

Ethylene [BAT Value Documentation, 1995]

Bolt¹

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Biological Exposure Values for Occupational Toxicants and Carcinogens , Vol. 2 (1995) The article contains sections titled: Metabolism and Kinetics Critical Toxicity Exposure and Effects Selection of the Indicators Methodology Evaluation of the Biological Exposure Equivalents for Carcinogenic Substances (EKA) Interpretation of the Data

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Chromosome aberrations in hospital workers: Evidence from surveillance studies in Italy (1963–1993)

Bonassi

Forni

Bigatti

et al. 1997

American J Industrial Med

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Hospital workers are occupationally exposed to various agents known or suspected to induce chromosome damage, the most studied being ionizing radiation. To determine the extent of chromosome damage in peripheral blood lymphocytes in this population, taking into account temporal changes and job titles, a re‐analysis of cytogenetic studies performed in four Italian laboratories in the period 1965–1993 was carried out. A total of 871 hospital workers and 617 controls, mainly coming from ad hoc studies or surveillance programs in occupational groups potentially exposed to ionizing radiation, were examined. The exposed to controls frequency ratio of chromosome aberrations was evaluated as the measure of effect within each dataset by job title, using multivariate Poisson regression analysis, which allowed an efficient control of confounding. Increased frequency of chromosome‐type aberrations among exposed subjects was found in all datasets, especially in those dealing with older data. Significantly higher frequencies are reported for various job titles, particularly for orthopedists, radiologists, anesthesists, and nurses among paramedical occupations. Decrease in exposure to ionizing radiation in hospital workers was documented through a targeted study in the critical group of radiologists. A similar time‐related reduction in the frequency of chromosome‐type aberrations also has been reported by the surveillance studies carried out over the most recent decades. These data substantiate the use of chromosome‐type aberrations as biomarkers of exposure in this occupational setting in the period evaluated. However, the increases observed also in workers with doubtful exposure to ionizing radiation indicate that other chromosome‐damaging agents may be involved and, in turn, suggest the extension of surveillance to a larger number of occupations. Am. J. Ind. Med. 31:353–360, 1997. © 1997 Wiley‐Liss, Inc.

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Biologic markers in ethylene oxide-exposed workers and controls

Cited by 66 publications

References 34 publications

A Study of Sister Chromatid Exchange and Somatic Cell Mutation in Hospital Workers Exposed to Ethylene Oxide

A Study of Sister Chromatid Exchange and Somatic Cell Mutation in Hospital Workers Exposed to Ethylene Oxide

Ethylene [BAT Value Documentation, 1995]

Chromosome aberrations in hospital workers: Evidence from surveillance studies in Italy (1963–1993)

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