Biological activities of lupeol

P, Wal; A, Wal; K, Govinda Sharma; Kumar, Awani

doi:10.4103/0975-8453.86298

Cited by 96 publications

(52 citation statements)

References 236 publications

(118 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Even if lupeol was isolated directly by CC on silica gel 60 from CSPE and not from CSPE4-5, we tested its activity due to data of the literature [18]. Lupeol exhibited a cytotoxic activity against the J774 cell line with an IC 50 value similar to that of the CSPE partition (IC 50 = 12.60 µ g/ml) but did not show selectivity against the WI38 cell line (selectivity index = 1.5).…”

Section: Resultsmentioning

confidence: 99%

Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia

Sahli

Dufloer

Beaufay

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Several Cirsium species are known for their uses in traditional medicine and consequently are studied for their phytochemical content and their biological activities. In the framework of a previous study conducted on eight extremophile plants from Tunisia, we highlighted that the crude methanolic extract of C. scabrum, a not investigated thistle, showed moderate but quite selective cytotoxic activity against the cancerous cell line J774 compared to the noncancerous cell line WI38 (IC50 = 11.53 μg/ml on J774, IC50 = 29.89 µg/ml on WI38, and selectivity index = 2.6). In the current study, the partitions of the leaves of C. scabrum were analyzed for their antiproliferative activity on the same cell lines. From the most active petroleum ether partition, we isolated four triterpenoids including lupeol, taraxasterol acetate, and a (1 : 1) mixture of 25-hydroperoxycycloart-23-en-3β-ol and 24-hydroperoxycycloart-25-en-3β-ol. These two cycloartane-type triterpenoids are mostly responsible for this cytotoxic activity. On the other hand, the antimicrobial potential of this plant was also evaluated against 36 microorganisms. The moderate antibacterial activity against 6 Staphylococcus aureus and 2 Dermabacter hominis strains is mainly attributed to the butanol partition whose major compounds are glycosides of flavones.

show abstract

Section: Resultsmentioning

confidence: 99%

Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia

Sahli

Dufloer

Beaufay

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…The cytotoxic activity of this plant may be mainly attributed to the compound lupeol which was reported previously as anticancer agent [52]. …”

Section: Discussionmentioning

confidence: 99%

Phytochemistry and Pharmacological Studies of Citrus macroptera: A Medicinal Plant Review

Aktar

Foyzun

2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Citrus macroptera (family Rutaceae), commonly known as Sat Kara, is a pharmacologically diverse medicinal plant. Various parts of this plant, specifically fruit, have an immense range of medicinal uses in folk medicine directed for a number of ailments. A plethora of active phytochemical constituents of this plant have been revealed so far, namely, limonene, beta-caryophyllene, beta-pinene, geranial edulinine, ribalinine, isoplatydesmine, and so forth. Several studies demonstrated the exploration of pharmacological potential of various parts such as fruits, leaves, and stems of C. macroptera as antioxidant, cytotoxic, antimicrobial, thrombolytic, hypoglycemic, anxiolytic, antidepressant, cardioprotective, and hepatoprotective. Furthermore, inhibition of in vitro α-amylase, inhibition of paracetamol induced hepatotoxicity, and potentiation of brain antioxidant enzyme are also ascertained. In present review, comprehensive study focused on knowledge regarding several phytopharmacological activities of Citrus macroptera has been described.

show abstract

“…It significantly inhibits vascular adhesion molecule 1 and intracellular adhesion molecule 1 expression in TNF alpha-stimulated HAEC as well as the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuates the phosphorylation of nuclear factor-kB p65 (Loizou et al 2010) and decreases cholesterol synthesis at the level of HMG-CoA reductase gene expression (Field et al 1997). Lupeol [3], a pentacylic triterpene has demonstrated anti-inflammatory, antiarthritic, antiangiogenic, hepatoprotective, hypotensive, cardioprotective and antileukemia activities (You et al 2003;Wal et al 2011). …”

Section: Rootmentioning

confidence: 99%

Phytochemical Studies

Jain

Verma

2012

SpringerBriefs in Pharmacology and Toxicology

View full text Add to dashboard Cite

Many chemical compounds have been isolated from different parts of B. ceiba worldwide. These belong mostly to phenolics, flavonoids, sesquiterpenoids, steroids, naphthoquinones and neolignans. Totally 16 compounds have been isolated from root, 8 from root bark, 3 from stem bark, 3 from heart wood, 2 from leaves, 78 from flowers, 19 from seeds and 11 from gum. Several of these compounds are novel and isolated for the first time. Compounds isolated from this plant possess very important biological activities including immunomodulatory, cytotoxic, antineoplastic, anti-inflammatory, hypotensive, hypolipidemic, antihyperglycemic and antioxidant.

show abstract

Biological activities of lupeol

Cited by 96 publications

References 236 publications

Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia

Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia

Phytochemistry and Pharmacological Studies of Citrus macroptera: A Medicinal Plant Review

Phytochemical Studies

Contact Info

Product

Resources

About