Biological and pathological consequences of feline infectious peritonitis virus infection in the cheetah

Evermann, James F.; Heeney, Jonathan L.; Roelke, Melody E.; McKeirnan, A. J.; O’Brien, Stephen J.

doi:10.1007/bf01310822

Cited by 57 publications

(64 citation statements)

References 56 publications

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“…It is likely that FCoV mutations occur regularly but the probability of emergence of FIP depends on cat density as well as underlying comorbidity (e.g., feline immunodeficiency virus infection) that encourages high viral loads in an individual or population. Mortality from FIP has been reported in nondomestic cats such as cheetahs (Acinonyx jubatus), and is partially attributed in that case to high homozygosity in the host and an inferred lack of population resistance (Evermann et al, 1988). Given the biology and pathogenesis of FCoV and FIP virus in large felids, we would expect FCoV to be most common in high-density populations or those with common mountain lion-domestic cat interactions, and FIP to occur sporadically.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Exposure to Feline Pathogens in California Mountain Lions (Puma Concolor)

Foley¹,

Swift

Fleer³

et al. 2013

Journal of Wildlife Diseases

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ABSTRACT:The primary challenge to mountain lion population viability in California is habitat loss and fragmentation. These habitat impacts could enhance disease risk by increasing contact with domestic animals and by altering patterns of exposure to other wild felids. We performed a serologic survey for feline pathogens in California mountain lions (Puma concolor) using 490 samples from 45 counties collected from 1990 to 2008. Most mountain lions sampled were killed because of depredation or public safety concerns and 75% were adults. Pathogens detected by serosurvey in sampled mountain lions included feline panleukopenia virus (39.0%), feline calicivirus (33.0%), feline coronavirus (FCoV, 15.1%), feline herpesvirus (13.0%), heartworm (12.4%), feline leukemia virus (5.4%), and canine distemper virus (3%). An outbreak of heartworm exposure occurred from 1995 to 2003 and higher than expected levels of FCoV-antibody-positive mountain lions were observed from 2005 to 2008, with foci in southern Mendocino and eastern Lake counties. We show that the majority of mountain lions were exposed to feline pathogens and may be at risk of illness or fatality, particularly kittens. Combined with other stressors, such as ongoing habitat loss, infectious disease deserves recognition for potential negative impact on mountain lion health and population viability.

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Exposure to Feline Pathogens in California Mountain Lions (Puma Concolor)

Foley¹,

Swift

Fleer³

et al. 2013

Journal of Wildlife Diseases

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“…The higher incidence of FIP among purebred cats (Scott, 1991), cheetahs (Evermann et al, 1988) and cats from FIP-susceptible bloodlines may be an indication for a genetic predisposition.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of feline coronavirus types I and II in cats with histopathologically verified feline infectious peritonitis

Benetka

Kübber‐Heiss

Kolodziejek

et al. 2004

Veterinary Microbiology

113

106

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Feline coronaviruses (FCoV) vary widely in virulence causing a spectrum of clinical manifestations reaching from subclinical course to fatal feline infectious peritonitis (FIP). Independent of virulence variations they are separated into two different types, type I, the original FCoV, and type II, which is closely related to canine coronavirus (CCV). The prevalence of FCoV types in Austrian cat populations without FIP has been surveyed recently indicating that type I infections predominate. The distribution of FCoV types in cats, which had succumbed to FIP, however, was fairly unknown. PCR assays have been developed amplifying parts of the spike protein gene. Type-specific primer pairs were designed, generating PCR products of different sizes. A total of 94 organ pools of cats with histopathologically verified FIP was tested. A clear differentiation was achieved in 74 cats, 86% of them were type I positive, 7% type II positive, and 7% were positive for both types. These findings demonstrate that in FIP cases FCoV type I predominates, too, nonetheless, in 14% of the cases FCoV type II was detected, suggesting its causative involvement in cases of FIP.

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“…2001). It has been suggested that species exhibiting low MHC variation might have a higher susceptibility to infectious disease (Evermann et al . 1988; Mikko et al .…”

Section: Introductionmentioning

confidence: 99%

Major histocompatibility complex and microsatellite variation in two populations of wild gorillas

et al. 2004

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In comparison to their close relatives the chimpanzees and humans, very little is known concerning the amount and structure of genetic variation in gorillas. Two species of gorillas are recognized and while the western gorillas number in the tens of thousands, only several hundred representatives of the mountain gorilla subspecies of eastern gorillas survive. To analyse the possible effects of these different population sizes, this study compares the variation observed at microsatellite and major histocompatibility complex (MHC) loci in samples of wild western and mountain gorillas, collected using a sampling scheme that targeted multiple social groups within defined geographical areas. Noninvasive samples proved a viable source of DNA for sequence analysis of the second exon of the DRB loci of the MHC. Observed levels of variation at the MHC locus were similar between the two gorilla species and were comparable to those in other primates. Comparison of results from analysis of variation at multiple microsatellite loci found only a slight reduction in heterozygosity for the mountain gorillas despite the relatively smaller population size.

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Biological and pathological consequences of feline infectious peritonitis virus infection in the cheetah

Cited by 57 publications

References 56 publications

Risk Factors for Exposure to Feline Pathogens in California Mountain Lions (Puma Concolor)

Risk Factors for Exposure to Feline Pathogens in California Mountain Lions (Puma Concolor)

Prevalence of feline coronavirus types I and II in cats with histopathologically verified feline infectious peritonitis

Major histocompatibility complex and microsatellite variation in two populations of wild gorillas

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