The article presents data from field studies of the use of biological products and fertilizers with microelements in the cultivation of four crops: winter wheat, sunflower, grain corn, soybeans. Schemes for the introduction of drugs, indicators of the comparative economic efficiency of their use are presented. The results of the conducted studies have proved the effectiveness of the use of biological products and fertilizers with trace elements. For all crops, there was an increase in yields: winter wheat - by 1.2%, sunflower - by 7.5%, corn for grain - by 7.8%, soybeans - by 13.6%. The increase in profit from each hectare of crops was: for winter wheat - by 8.7%, sunflower - by 9.2%, corn for grain - by 6.9%, soybeans - by 17.9%.