Biological constraint, evolutionary spandrels and antagonistic pleiotropy

Gems, David; Kern, Carina C.

doi:10.1016/j.arr.2024.102527

Ageing Research Reviews

2024

DOI: 10.1016/j.arr.2024.102527

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Biological constraint, evolutionary spandrels and antagonistic pleiotropy

David Gems,

Carina C. Kern

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2024

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Cited by 2 publications

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The evolution of ageing: classic theories and emerging ideas

Mc Auley

2024

Biogerontology

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Ageing is generally regarded as a non-adaptive by-product of evolution. Based on this premise three classic evolutionary theories of ageing have been proposed. These theories have dominated the literature for several decades. Despite their individual nuances, the common thread which unites them is that they posit that ageing results from a decline in the intensity of natural selection with chronological age. Empirical evidence has been identified which supports each theory. However, a consensus remains to be fully established as to which theory best accounts for the evolution of ageing. A consequence of this uncertainty are counter arguments which advocate for alternative theoretical frameworks, such as those which propose an adaptive origin for ageing, senescence, or death. Given this backdrop, this review has several aims. Firstly, to briefly discuss the classic evolutionary theories. Secondly, to evaluate how evolutionary forces beyond a monotonic decrease in natural selection can affect the evolution of ageing. Thirdly, to examine alternatives to the classic theories. Finally, to introduce a pluralistic interpretation of the evolution of ageing. The basis of this pluralistic theoretical framework is the recognition that certain evolutionary ideas will be more appropriate depending on the organism, its ecological context, and its life history.

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The evolution of ageing: classic theories and emerging ideas

Mc Auley

2024

Biogerontology

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Epigenetic clocks and programmatic aging

Gems,

Virk,

de Magalhães

2024

Ageing Research Reviews

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Biological constraint, evolutionary spandrels and antagonistic pleiotropy

Cited by 2 publications

References 103 publications

The evolution of ageing: classic theories and emerging ideas

The evolution of ageing: classic theories and emerging ideas

Epigenetic clocks and programmatic aging

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