Biological evaluation and molecular docking of baicalin and scutellarin as Helicobacter pylori urease inhibitors

Yu, Anna Xiaodan; Zheng, Rong-Bo; Xie, Jianhui; Su, Juanjuan; Huang, Xiaojun; Wang, Yonghong; Zheng, Yifeng; Mo, Zhi-Zhun; Wu, Xiaoli; Wu, Dian‐Wei; Liang, Yeer; Zeng, Hong‐Yan; Su, Zi‐Ren; Huang, Ping

doi:10.1016/j.jep.2014.12.041

Cited by 67 publications

(36 citation statements)

References 48 publications

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“…H. pylori can be inhibited by baicalin and baicalein, demonstrating different degrees of antibacterial effects against Staphylococcus aureus , Streptococcus , Neisseria meningitidis , and diphtheria [8, 9]. Studies have found that baicalein antihistaminic effects are exerted to protect the gastric mucosa and prevent ulceration [10].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Pudilan Anti‐Inflammatory Oral Liquid on the Treatment of Mild Recurrent Aphthous Ulcers

Jin

Lin

Song

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Recurrent aphthous ulcers are the most common recurrent oral mucosal lesions characterized by recurrence and pain. The aim of this research is to evaluate the short-term curative effect of the traditional Chinese medicine “Pudilan anti-inflammatory oral liquid” on mild recurrent aphthous ulcers. A total of 234 patients were divided into a treatment group and a control group. Both groups used vitamin B2 as the basis of treatment. The treatment group took a Pudilan anti-inflammatory oral solution for 8 days while the control group was given a liquid placebo. The ulcer size, pseudomembrane, peripheral congestion, and pain scores of the treatment group were lower than before treatment. The curative effect on the Pudilan group was statistically significant compared with the control group. The final therapeutic effect on the treatment group was better than that on the control group. The healing time of mild recurrent aphthous ulcers can be shortened by Pudilan anti-inflammatory oral liquid, and pain is relieved without adverse reactions. Pudilan provides a new reference drug for the treatment of mild recurrent oral ulcers.

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Section: Discussionmentioning

confidence: 99%

The Effect of Pudilan Anti‐Inflammatory Oral Liquid on the Treatment of Mild Recurrent Aphthous Ulcers

Jin

Lin

Song

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Structural analysis of the active sites of H. pylori urease revealed that it consists of dinuclear nickel atoms, which are associated with carbamylated lysine residues. Furthermore, the catalytic potential has a strong association with cysteine residues containing sulfhydryl groups, located on the mobile flap in close proximity to the active site (56).…”

Section: Bioinformatics Studiesmentioning

confidence: 99%

InsideHelicobacter pylori: A Serious Threat to Humans

Rehman¹

2018

Avicenna J Clin Microbiol Infect

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Helicobacter pylori is a close relative of Campylobacter species, with the ability to colonize the human gastrointestinal tract. This gastric pathogen is a flagellated, Gram-negative bacterium. Chronic gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma, duodenal ulcer, and gastric ulcer are the outcomes of persistent infection with this pathogen. Recent studies have shown a direct relationship between H. pylori and development of gastric adenocarcinoma. A 7-to 14-day course of broad-spectrum antibiotics is required for the elimination of H. pylori. Treatment failure due to chromosomally encoded antibiotic resistance is increasing rapidly, which underlines the importance of new regimens against this pathogen. The vast diversity of natural compounds in living microorganisms such as algae, as well as various dietary components in herbs and foods, provides a new opportunity for the establishment of therapeutic compounds. The majority of intra-and extracellular metabolites in algae have potent inhibitory effects on H. pylori, leading to the development of novel therapeutic agents for gastric ulcer. Application of bioinformatics-based tools has encouraged the scientific community to find novel targets and have led to the development of in silico drugs against the pathogenic elements of H. pylori. Further research on metabolite-based therapeutic agents with the aid of modern tools can be a milestone in the management of the emerging risk of gastric ulcer.

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“…In humans the urease of Helicobacter pylori causes infections of urinary and gastrointestinal tract [7], such as peptic ulcer and the stomach cancer. [12] Other urease associated diseases include hepatic encephalopathy, urolithiasis, urinary catheter encrustation, pyelonephritis and hepatic coma. [5] The urease activity of Helicobacter pylori plays an important role in the pathogenesis of peptic and gastric ulcer.…”

Section: Indo Global Journal Of Pharmaceutical Sciences Issn 2249-1023mentioning

confidence: 99%

“…[5] The urease activity of Helicobacter pylori plays an important role in the pathogenesis of peptic and gastric ulcer. [12] Therefore, urease inhibitors have the potential to be used as anti-ulcer drugs. Ureases are inhibited by different classes of compounds.…”

Section: Indo Global Journal Of Pharmaceutical Sciences Issn 2249-1023mentioning

confidence: 99%

Synthesis, Urease Inhibition, Antimicrobial and Antioxidant Studies of 3,4,5-Trihydroxy Benzoic Acid Derivatives

Mondal¹,

Sharma²,

Kakkar³

et al. 2018

IGJPS

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Biological evaluation and molecular docking of baicalin and scutellarin as Helicobacter pylori urease inhibitors

Cited by 67 publications

References 48 publications

The Effect of Pudilan Anti‐Inflammatory Oral Liquid on the Treatment of Mild Recurrent Aphthous Ulcers

The Effect of Pudilan Anti‐Inflammatory Oral Liquid on the Treatment of Mild Recurrent Aphthous Ulcers

InsideHelicobacter pylori: A Serious Threat to Humans

Synthesis, Urease Inhibition, Antimicrobial and Antioxidant Studies of 3,4,5-Trihydroxy Benzoic Acid Derivatives

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