“…There are -amylase and -glucosidase enzyme inhibitors, 16 EGFRWT and EGFRT790M inhibitors, 17 PIM-1/2 kinase inhibitors, 18 Mcl-1 inhibitors, 19 DNA gyrase active inhibitors, 20,21 potential inhibitors against Alzheimer's dis-ease, 4 and anticancer agents with dual VEGFR-2/HER-2 inhibitory activity. 22 They also exhibit antioxidant, 16,17 neuroprotective, 23 anticancer, 3,24 anti-inflammatory, antipyretic and ulcerogenic, 25 antimicrobial, 21,26 antifungal (antibiofilm), 20 and antiproliferative activities 27 and can be used as drugs for the treatment of autoimmune diseases and as novel neuroregulators. 28 Milrinone, olprinone, and their other analogues containing a fragment of 2-oxo-1,2-dihydropyridine-3-carbonitrile are used as cardiotonic drugs for the treatment of heart failure.…”