2022
DOI: 10.1080/14756366.2022.2135512
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Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR WT and EGFR T790M inhibitors

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Cited by 22 publications
(29 citation statements)
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“…It is considered the second driving cause of death in the world. 1,2 According to global statistics, cancer is considered one of the primary causes of death worldwide. 3,4…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…It is considered the second driving cause of death in the world. 1,2 According to global statistics, cancer is considered one of the primary causes of death worldwide. 3,4…”
Section: Introductionmentioning
confidence: 99%
“…Briefly, the principal pharmacophoric features of EGFR inhibitors ( Fig. 2 ) were identified as follows: 2 …”
Section: Introductionmentioning
confidence: 99%
“…Numerous obstacles face human health in the modern medical era, particularly cancer [ 1 ]. Therefore, new small compounds should continuously be added to the treatment toolbox for cancer to specifically target tumour cells while posing little risk of damage to normal cells [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…There are -amylase and -glucosidase enzyme inhibitors, 16 EGFRWT and EGFRT790M inhibitors, 17 PIM-1/2 kinase inhibitors, 18 Mcl-1 inhibitors, 19 DNA gyrase active inhibitors, 20,21 potential inhibitors against Alzheimer's dis-ease, 4 and anticancer agents with dual VEGFR-2/HER-2 inhibitory activity. 22 They also exhibit antioxidant, 16,17 neuroprotective, 23 anticancer, 3,24 anti-inflammatory, antipyretic and ulcerogenic, 25 antimicrobial, 21,26 antifungal (antibiofilm), 20 and antiproliferative activities 27 and can be used as drugs for the treatment of autoimmune diseases and as novel neuroregulators. 28 Milrinone, olprinone, and their other analogues containing a fragment of 2-oxo-1,2-dihydropyridine-3-carbonitrile are used as cardiotonic drugs for the treatment of heart failure.…”
mentioning
confidence: 99%
“…9,[12][13][14][15] 2-Oxonicotinonitrile core is the main structural unit in various drugs and constantly attracts the attention of researchers due to its extremely diverse biological properties. There are -amylase and -glucosidase enzyme inhibitors, 16 EGFRWT and EGFRT790M inhibitors, 17 PIM-1/2 kinase inhibitors, 18 Mcl-1 inhibitors, 19 DNA gyrase active inhibitors, 20,21 potential inhibitors against Alzheimer's dis-ease, 4 and anticancer agents with dual VEGFR-2/HER-2 inhibitory activity. 22 They also exhibit antioxidant, 16,17 neuroprotective, 23 anticancer, 3,24 anti-inflammatory, antipyretic and ulcerogenic, 25 antimicrobial, 21,26 antifungal (antibiofilm), 20 and antiproliferative activities 27 and can be used as drugs for the treatment of autoimmune diseases and as novel neuroregulators.…”
mentioning
confidence: 99%