Biological false positive Wassermann reactions in Uganda.

Foster, W. D.; Kerchan, L. L. O.

doi:10.1136/sti.42.4.272

Cited by 4 publications

(2 citation statements)

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“…Beecher (1960) analysed the inpatient statistics of Kiambu Hospital, Kenya, from 1939-58. Whereas the number of cases of early syphilis ranged from 1-5 to 10-9 per 1000 admissions during the first half of the period under review, none was recorded in 1958. Reports from Kampala, Uganda, also show that the number of positive cases, using comparable test procedures, decreased considerably between 1966 and 1970 (Foster and Kerchan, 1966;Massawe, 1970). In West Africa Ba et al (1965) studied the epidemiological aspects of syphilis serology of outpatients in Dakar, Senegal, over the period 1956-64; the percentage of positive results showed a steady decline.…”

Section: Review Of the Literaturementioning

confidence: 96%

“…Specific procedures are in very limited use in developing countries. Foster and Kerchan (1966) commented on the lack of specificity of the Wassermann reaction compared with the Reiter protein complement-fixation test. Mann et al (1966) found that more than 50 % of Venereal Disease Research Laboratory (VDRL) slide tests gave biological falsepositive (BFP) results when the TPI test was used to confirm the results.…”

Section: Syphilis Serology and Biological False-positive (Bfp) Reactionsmentioning

confidence: 99%

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Venereal syphilis in tropical Africa.

Rampen¹

1978

Sexually Transmitted Infections

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SUMMARY A steady decline in the incidence of positive results to the Kahn test is reported in Malawian patients during the period 1968-75. Other studies have shown that the incidence of early and late syphilis in sub-Saharan Africa has dropped considerably over the past few decades. The number of reported cases of early syphilis in certain urban areas, however, appears to be high. It is suggested that the downward trend in the incidence of syphilis in Africa is related to the increased and often indiscriminate use of penicillin. IntroductionAnnual statistics have shown an apparent increase in the incidence of infectious syphilis in most western countries since about 1955. This increase is sometimes referred to as being 'world-wide', thus indicating that the same trend has also been observed in Africa. Although reliable information on the prevalence of venereal syphilis in African countries is scarce, it is a common assumption that syphilis is highly prevalent in most developing countries (Harris, 1975). The apparent increase in the incidence of infectious syphilis in Africa is attributed to changing environmental patterns, principally accelerated urbanisation and general migration. Moreover, the successful eradication of yaws in the 1950s is said to have made whole populations susceptible to infection with Treponema pallidum.During a three-year stay in Malawi, I noticed that the number of patients with early syphilis seen at the skin clinics in Blantyre was surprisingly low. Only 21 cases were registered over three years, whereas 1200-1600 new dermatological cases were seen each year. A study was (Trowell, 1960).In East Africa several authors had analogous findings. Beecher (1960) analysed the inpatient statistics of Kiambu Hospital, Kenya, from 1939-58. Whereas the number of cases of early syphilis ranged from 1-5 to 10-9 per 1000 admissions during the first half of the period under review, none was recorded in 1958. Reports from Kampala, Uganda, also show that the number of positive cases, using comparable test procedures, decreased considerably between 1966 and 1970 (Foster and Kerchan, 1966;Massawe, 1970). In West Africa Ba et al (1965) studied the epidemiological aspects of syphilis serology of outpatients in Dakar, Senegal, over the period 1956-64; the percentage of positive results showed a steady decline. These observations agree with recent reports from other African countries, indicating a low incidence of positive serological results in patients at prenatal consultations (Osoba and Onifade, 1973;Meheus et al, 1975).In contrast, a very high incidence of syphilis has been reported from a few, predominantly urban, areas. In Kampala venereal diseases, in-364 on 12 May 2018 by guest. Protected by copyright.

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Section: Review Of the Literaturementioning

confidence: 96%

Section: Syphilis Serology and Biological False-positive (Bfp) Reactionsmentioning

confidence: 99%

Venereal syphilis in tropical Africa.

Rampen¹

1978

Sexually Transmitted Infections

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Serological tests for treponemal infection in leprosy patients. An evaluation of the fluorescent treponemal antibody absorption (FTA--ABS) test.

Garner¹,

Backhouse²,

Collins³

et al. 1969

Sexually Transmitted Infections

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Changing patterns in the organization of the venereal diseases and treponematoses service in Uganda.

Arya¹

1973

Sexually Transmitted Infections

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Uganda, which is primarily an agricultural and pastoral country, forms a beautiful part of the main plateau of East Africa. It is bordered by Kenya on the east, Congo and Rwanda on the west, Southern Sudan on the north, and Tanzania and Lake Victoria on the south. Its four regions-Central (Buganda), Eastern, Western, and Northernroughly correspond with an ethnic complex. The northern region has largely Nilotic and Sudanic people, the eastern region Bantu and Nilo-Hamitic people, and the western and central regions have Bantu-speaking peoples. Each region has four to six districts, most of which have ethnic populations with distinct cultural characteristics such as diet and living habits. Polygamy is not uncommon. There are also important African immigrant communities from neighbouring countries who account for over 5 per cent. of Uganda's population of 9 54 millions (Uganda, 1971, 1972). Over 90 per cent. of the population live in rural areas and 46 per cent. are

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Biological false positive Wassermann reactions in Uganda.

Cited by 4 publications

References 4 publications

Venereal syphilis in tropical Africa.

Venereal syphilis in tropical Africa.

Serological tests for treponemal infection in leprosy patients. An evaluation of the fluorescent treponemal antibody absorption (FTA--ABS) test.

Changing patterns in the organization of the venereal diseases and treponematoses service in Uganda.

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