Biological hydroxyapatite obtained from fish bones

Boutinguiza, M.; Pou, J.; Comesaña, R.; Lusquiños, F.; Carlos, Alejandro de; León, B.

doi:10.1016/j.msec.2011.11.021

Cited by 322 publications

(239 citation statements)

References 48 publications

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“…Fish bone mainly consists of minerals (60e70 g/100 g) and collagen (~20 g/100 g) (Toppe, Albrektsen, Hope, & Aksnes, 2007). Researchers have been investigating the utilization of fish bone as raw material for value added products, such as calcium enriched fish bone powder (Jeyasanta, Aiyamperumal, & Patterson, 2013), biological hydroxyapatite (HAP) (Boutinguiza, Pou, Comesaña, Lusquiños, & de Carlos, 2012) and gelatin (Akagündüz et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Physicochemical properties of nano fish bone prepared by wet media milling

Yin

Park

Xiong

2015

LWT - Food Science and Technology

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Section: Introductionmentioning

confidence: 99%

Physicochemical properties of nano fish bone prepared by wet media milling

Yin

Park

Xiong

2015

LWT - Food Science and Technology

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“…Reports indicate that hard products obtained after the fish filleting process has been completed are used as a source of calcium and phosphorus compounds [16][17][18][19][20]. Fish bone tissue dry matter has a 60−70% mineral content, mainly calcium phosphate and hydroxyapatite [21,22], while calcium content in mineral mass is at a level of 60% [23].…”

Section: Introductionmentioning

confidence: 99%

Production of calcium preparations by technology of saltwater fish by product processing

et al. 2015

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Abstract:The paper presents the technology of processing Baltic cod (Gadus morhua callarias) and Atlantic salmon (Salmo salar) backbones -by-products from fish processing -for the production of calcium preparations. The raw material for the process consisted of backbones with remaining muscle tissue, devoid of heads and fins (30 kg of each type of backbones). The processing included the following stages: cutting, preliminary processing in an alkaline environment (soaking in 2 M NaOH), processing with 0.1% citric acid, aroma removal and material disinfection (5% H 2 O 2 ), rinsing with tap water, drying, and grinding the end-product. Calcium preparations from cod (BCP) and salmon (ASP) in the amounts of 1.20 kg and 1.62 kg, respectively, characterized by high calcium content (27.79% in BCP, and 24.92% in ASP) and low protein and fat content (14.20% and 0.25% for BCP, and 10.78% and 0.12% for ASP, respectively) were obtained. The study demonstrated the effectiveness of this technology for production of calcium preparations from fish backbones.

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“…Allograft memiliki resiko autoimun, yaitu penolakan karena sistem kekebalan tubuh manusia. Xenograft dibuat dari spesies yang berbeda, misalnya dari limbah tulang ikan [2], limbah tulang paha sapi [3] dan limbah kerang hijau [4]. Synthetic graft dibuat dari bahan sintetik.…”

Section: Pendahuluanunclassified

Pembuatan Graft Tulang Dengan Proses Ekstraksi Senyawa Hidroksiapatit Dari Tulang Korteks Sapi

Anisah¹,

Delina²,

Aisah³

et al. 2018

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AbstrakPembuatan senyawa hidrosiapatit dari tulang kortek paha sapi dengan proses ekstraksi telah dilakukan. Penelitian ini bertujuan untuk menghilangkan senyawa organik pada tulang sehingga dapat digunakan sebagai bahan baku graft tulang. Metode yang digunakan adalah metode kimia dengan merendam tulang di dalam larutan Natrium Hidroksida (NaOH). Pengaruh variasi konsentrasi dan waktu perendaman NaOH terhadap proses ekstraksi tulang dikaji. Variasi konsentrasi larutan yang digunakan adalah 1M, 2M dan 3M dengan waktu perendaman 30 menit, 60 menit, dan 90 menit di dalam autoklaf bertekanan 1,5 atm dan temperatur 121°C. Hasil rendaman dianalisa dengan FTIR dan menunjukan adanya puncak gugus fungsi zat anorganik P-O, CO32-, dan O-H menyerupai kandungan tulang manusia. Sampel yang direndam pada larutan NaOH pada konsentrasi 1M dan 2M dengan waktu perendaman 30 menit masih ditemukan gugus fungsi C-H, yang mengindikasikan bahwa serbuk hidroksiapatit masih mengandung material organik sehingga beresiko pada reaksi penolakan oleh tubuh manusia saat diimplan. Namun demikian, serbuk hidroksiapatit yang dihasilkan dengan perendaman pada konsentrasi 3M dengan waktu 30 menit sudah tidak mengandung unsur organik, sehingga dapat digunakan sebagai bahan baku graft tulang.Kata-kata kunci: hidroksiapatit, kortek tulang sapi, Natrium Hidroksida, ekstraksi, graft tulang. AbstractThe extraction of hydroxyapatite compounds from thigh bones cortex has been done. This research was aimed to remove the organic substances in the bones, so that it can be maintained as the raw material of a bone graft. The research employed a chemical method, the bone was soaked in the Natrium Hydroxide (NaOH) solution. The effect of various concentration and duration of bone's immersion in NaOH were also studied. The solution's various concentrations were 1M, 2M and 3M, therefore the various of immersion duration were 30 minutes, 60 minutes and 90 minutes in a 1.5 atm autoclave at a temperature of 121o C. The immersion results were studied throughout FTIR. The results showed that there were some peaks of the inorganic P-O, CO3 2-and O-H substance function, correspond to a human bone characteristic. Samples which were immersed in the 1M and 2M of NaOH solution with duration of 30 minutes have yet a C-H functional group. It indicated that the hydroxyapatite powders have yet organic substances, so there is still a risk of rejection by the human body when it is implanted. However, the sample which was immersed in 3M of NaOH solution with duration of 30 minutes has no any organic substances, it can be used as the raw material of a bone graft.

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Biological hydroxyapatite obtained from fish bones

Cited by 322 publications

References 48 publications

Physicochemical properties of nano fish bone prepared by wet media milling

Physicochemical properties of nano fish bone prepared by wet media milling

Production of calcium preparations by technology of saltwater fish by product processing

Pembuatan Graft Tulang Dengan Proses Ekstraksi Senyawa Hidroksiapatit Dari Tulang Korteks Sapi

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