Biological properties of calcium phosphate biomaterials for bone repair: a review

Lu, JingYi; Yu, Huijun; Chen, Chuanzhong

doi:10.1039/c7ra11278e

Cited by 153 publications

(85 citation statements)

References 151 publications

(184 reference statements)

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“…Hydroxyapatite is an osteoconductive material, presenting a porosity similar to that of native bone and thereby promoting the growth of bone tissue along the surface or within the pores of the scaffold [ 40 ]. In addition, the calcium and phosphate ions released during HAp degradation induce an osteogenic response, contributing to the osteoinductivity of these materials [ 3 ].…”

Section: Bone Tissue Engineering Scaffoldsmentioning

confidence: 99%

Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices

Witte

Fratila‐Apachitei

Zadpoor

et al. 2018

Regenerative Biomaterials

420

316

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In recent years, bone tissue engineering has emerged as a promising solution to the limitations of current gold standard treatment options for bone related-disorders such as bone grafts. Bone tissue engineering provides a scaffold design that mimics the extracellular matrix, providing an architecture that guides the natural bone regeneration process. During this period, a new generation of bone tissue engineering scaffolds has been designed and characterized that explores the incorporation of signaling molecules in order to enhance cell recruitment and ingress into the scaffold, as well as osteogenic differentiation and angiogenesis, each of which is crucial to successful bone regeneration. Here, we outline and critically analyze key characteristics of successful bone tissue engineering scaffolds. We also explore candidate materials used to fabricate these scaffolds. Different growth factors involved in the highly coordinated process of bone repair are discussed, and the key requirements of a growth factor delivery system are described. Finally, we concentrate on an analysis of scaffold-based growth factor delivery strategies found in the recent literature. In particular, the incorporation of two-phase systems consisting of growth factor-loaded nanoparticles embedded into scaffolds shows great promise, both by providing sustained release over a therapeutically relevant timeframe and the potential to sequentially deliver multiple growth factors.

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Section: Bone Tissue Engineering Scaffoldsmentioning

confidence: 99%

Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices

Witte

Fratila‐Apachitei

Zadpoor

et al. 2018

Regenerative Biomaterials

420

316

View full text Add to dashboard Cite

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“…Ergun et al proved increased human osteoblast adhesion on nano CaPs with higher Ca/P molar ratios of up to 2.5 and provided evidence that Ca/P ratios should be maximized up to 2.5. The formation, dissolution, and transformation of CaPs depend on their body nature (particle size, crystallographic features, density) and the nature of the solution (composition, pH, temperature, supersaturation in free calcium and phosphate ions) . Each CaP possesses its own thermodynamic solubility; for example, HA is the most stable phase (pH = 7 and 37°C) followed by tricalcium phosphate (TCP), octacalcium phosphate (OCP) and dicalciumphosphate dihydrate.…”

Section: Introductionmentioning

confidence: 99%

The comprehensive in vitro evaluation of eight different calcium phosphates: Significant parameters for cell behavior

et al. 2018

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“…Among several calcium phosphate materials, hydroxyapatite [HAP, Ca 10 (PO 4 ) 6 (OH) 2 ] is widely accepted as a bioactive and biocompatible material similar to the mineral component of bone and teeth, thanks to its osteogenic and osteoconductive properties and the ability to form strong bonds with host bone tissues (Haider, Haider, Han, & Kang, ; Lu, Yu, & Chen, ; Sistanipour, Meshkini, & Oveisi, ; Ye, Cai, Xu, Dou, & Hu, ). The main obstacle in the utilization of hydroxyapatite as a load‐bearing biomaterial is its poor mechanical properties (Lin & Chang, ).…”

Section: Introductionmentioning

confidence: 99%

Meso‐macroporous crack‐free nanohydroxyapatite coatings templated by C₁₂E₁₀ diblock copolymer on Ti6Al4V implant materials toward human osteoblast‐like cells

Sharafipour

Oveisi

Meshkini

2019

J Biomedical Materials Res

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Meso-macroporous nanohydroxyapatite coatings (MHACs) were synthesized on Ti6Al4V implant materials calcined at different temperatures using a nonionic diblock copolymer template (C 12 E 10 ) by sol-gel and dip-coating methods. To improve the bonding strength between the substrate and coating, a TiO 2 intermediate layer was applied on the surface of the substrates. The physicochemical and structural properties of MHAC samples were fully studied by X-ray diffraction, X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, scanning probe microscopy, field-emission scanning electron microscopy (FESEM), Brunauer-Emmett-Teller method, and contact angle measurements. Based on the data obtained, the hydroxyapatite phase with a flower-like morphology was formed on the Ti6Al4V substrates in all of the samples. According to confocal optical microscopy and FESEM images, there was no macrocrack and microcrack on the MHACs, whereas they were accompanied by macroporosities and mesoporosities on top of the coatings. By increasing the calcination temperature from 500 C to 650 C, the crystallite sizes increased, while the surface roughness value and hydrophilicity decreased. A reduction in specific surface area and an increase in the pore diameters occurred as the calcination temperature increased. In addition, the assessment of protein adsorption behavior over the samples revealed that the adsorption amounts significantly increased as the substrates were coated with HAP; however, the affinity of surface for protein adsorption was strictly dependent on the surface topography and hydrophilicity. in vitro cellular assay disclosed a great cytocompatibility in terms of adhesion and proliferation in MHAC samples as compared with that in TiO 2 -coated and bare substrates. Regarding the physicochemical properties and biological studies, MHAC calcined at 650 C was deemed optimal for bone tissue engineering. K E Y W O R D Scrack-free, diblock copolymer template, human osteoblast response, mesoporous, nanohydroxyapatite

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Biological properties of calcium phosphate biomaterials for bone repair: a review

Abstract: This article reviews the recent advances and various factors affecting the improvement of the biological properties of calcium phosphate for bone repair.

Cited by 153 publications

References 151 publications

Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices

Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices

The comprehensive in vitro evaluation of eight different calcium phosphates: Significant parameters for cell behavior

Meso‐macroporous crack‐free nanohydroxyapatite coatings templated by C₁₂E₁₀ diblock copolymer on Ti6Al4V implant materials toward human osteoblast‐like cells

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Biological properties of calcium phosphate biomaterials for bone repair: a review

Abstract: This article reviews the recent advances and various factors affecting the improvement of the biological properties of calcium phosphate for bone repair.

Cited by 153 publications

References 151 publications

Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices

Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices

The comprehensive in vitro evaluation of eight different calcium phosphates: Significant parameters for cell behavior

Meso‐macroporous crack‐free nanohydroxyapatite coatings templated by C12E10 diblock copolymer on Ti6Al4V implant materials toward human osteoblast‐like cells

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Product

Resources

About

Meso‐macroporous crack‐free nanohydroxyapatite coatings templated by C₁₂E₁₀ diblock copolymer on Ti6Al4V implant materials toward human osteoblast‐like cells