Biologically active acylthioureas and their Ni(II) and Cu(II) Complexes: Structural, spectroscopic, anti-proliferative, nucleolytic and antimicrobial studies

Synthesis, characterisation and biological activities of mixed ligand oxovanadium (IV) complexes derived from N,N‐diethyl‐N′‐para‐substituted‐benzoylthiourea and hydrotris(3,5‐dimethylpyrazolyl)borate

“…The antimicrobial activity of the current complexes is comparable with the previously published results for oxovanadium (IV) complexes. [ 21,22,93 ] As the same result of our complexes, moderate antifungal activity for oxovanadium (IV) complexes against various testing fungal strains was reported by Chohan et al [ 103 ] While, in most of the reported cases higher antimicrobial activity was exhibited upon coordination with oxovanadium (IV) metal. [ 65,92 ]…”

“…The antimicrobial activity of the current complexes is comparable with the previously published results for oxovanadium (IV) complexes. [21,22,93] As the same result of our complexes, moderate antifungal activity for oxovanadium (IV) complexes against various testing fungal strains was reported by Chohan et al [103] While, in most of the reported cases higher antimicrobial activity was exhibited upon coordination with oxovanadium (IV) metal. [65,92] Metal ions are adsorbed onto the cell walls of the microorganisms, disturbing the respiration processes of the cells, and thus, blocking the protein synthesis that is required for the further growth of the organisms which ultimately results in cell death.…”

“…[11][12][13][14] The chemistry of benzoylthiourea compound and its transition metal complexes has attracted interest due to their prospective use in a wide range of applications. Previous studies showed that benzoylthiourea complexes have antimicrobial, [15][16][17][18][19][20][21][22][23] antitumor [24][25][26][27][28] antioxidant, [24,29] cytotoxic [30] and insecticidal [31,32] properties. From a chemistry point of view, a notable feature of benzoylthiourea derivatives is due to its strong donor groups (carbonyl and thioamide), which make them very attractive for a coordination agent.…”

Crystal structure, Hirshfeld surface and computational study of 1-(9,10-dioxo-9,10-dihydroanthracen-1-yl)-3-propanoylthiourea

“…The versatility of acyl thioureas stems from their ease of preparation and ability to introduce different functionalities, resulting in compounds with very interesting biological properties including antifungal (del Campo et al, 2002Campo et al, , 2004, antitumor Herna ´ndez et al, 2005), antiviral, antibacterial, herbicidal, insecticidal and pharmacological activities (Binzet et al, 2006;Saeed et al, 2010). Recently, our research group reported the synthesis and crystal structures of a number of thiourea derivatives (Asegbeloyin et al, 2018(Asegbeloyin et al, , 2019Okpareke et al, 2020;Oyeka et al, 2021). In a continuation of our series on thiourea derivatives, we present herein the crystal structure, Hirshfeld surface and computational study of a new potential biologically active thiourea derivative with an aminoanthraquinone moiety.…”

A new antimicrobial PVC-based polymeric material incorporating bisacylthiourea complexes

“…Phenylthiourea derivatives have been proven to have great biological properties, including insecticide herbicidal or bactericidal properties [ 28 – 32 ], and the nature of the substituent is critical for their activities [ 33 ]. Arylthioureas have (O, N, S) potential donors and have been considered model compounds for various intermolecular and intramolecular interactions involving sulfur [ 34 ].…”