Biologically active atrial peptides.

Ballerman, B J; Brenner, B M

doi:10.1172/jci112206

Cited by 217 publications

(89 citation statements)

References 100 publications

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“…Indeed, in a recent study, we have shown that water deprivation significantly increased the total number of ANP receptors in renal glomeruli and adrenal zona glomerulosa membranes of the pregnant rat (49). The use of cANP (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23) allowed us to demonstrate that the population of ANPc receptors increases in the renal glomeruli and adrenal zona glomerulosa of the pregnant rat, whereas the ANPb receptor density remains unchanged (49). In contrast, the absence of upregulation of ANP receptors in fetal kidneys and adrenal glands from dehydrated mothers could be associated with the immaturity of those organs (49).…”

Section: Or Inmentioning

confidence: 98%

“…The density of ANPb receptors was assessed with rANP in the presence of an excess of cANP (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23) (0.1 mmol/l; Peninsula), a truncated ANP peptide which binds selectively to ANPc receptors. The density of ANPc receptors was obtained by subtracting the number of ANPb receptors from the total receptor population.…”

Section: Binding Assaymentioning

confidence: 99%

“…ANP is a cardiac hormone stored in atrial secretory granules (8) which vary in number during alterations of the electrolyte and fluid balance (9). ANP released into the blood circulation in response to atrial distension (10) exerts its biological activity through specific receptors mainly located in the renal glomeruli and adrenal zona glomerulosa (11).…”

Section: Introductionmentioning

confidence: 99%

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Atrial natriuretic peptide and aldosterone secretions, and atrial natriuretic peptide-binding sites in kidneys and adrenal glands of pregnant and fetal rats in late gestation in response to a high-salt diet

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Montel

et al. 2000

European Journal of Endocrinology

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Objective: This study aimed at determining, in the term pregnant rat, whether maternal and fetal plasma atrial natriuretic peptide (ANP) concentrations were modified in response to an oral sodium load, and to investigate whether any changes in plasma concentrations were able to modify the density and affinity of the different ANP-binding site subtypes in maternal and fetal kidneys and adrenal glands. Methods: Pregnant rats kept in metabolic cages were divided into two groups. The normal sodium diet group had free access to rat chow and tap water whereas the high sodium diet group received 1% NaCl as drinking water for 10 consecutive days from day 11 to day 21 of gestation with free access to standard rat chow. Pregnant rats from both groups were killed by decapitation on day 21 of gestation. The plasma ANP and aldosterone concentrations were determined by RIA. The density and affinity of ANP receptors were determined in the maternal and fetal adrenal glands and kidneys. Results: In the pregnant rats on the high-salt diet, the sodium and water intakes, as well as the urine volume and sodium excretion, were significantly higher than in the control group. After 10 days of high-salt intake, water and sodium retentions were not significantly different in the two groups, indicating that the pregnant rats were able to excrete excess salt. The high sodium intake did not change the body weight of the pregnant rats but did increase the body weight of the fetal rats. Maternal and fetal hematocrits remained unchanged in both groups, the high sodium intake did not modify plasma sodium concentration in the maternal rats but increased that of the fetuses, indicating an accumulation of sodium in the fetal rats. The dietary sodium intake did not change the plasma ANP concentrations but significantly decreased the plasma aldosterone concentrations in both the maternal and fetal rats. In response to the high-salt diet, the density and affinity of total ANP, ANPb and ANPc receptors were not altered in the maternal isolated renal glomeruli or the adrenal zona glomerulosa membranes or the fetal adrenal gland and kidney membrane preparations. Conclusion: These results suggest that ANP is not involved in the regulation of water and electrolyte balance in maternal and fetal rats during salt-loaded intake.

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Section: Or Inmentioning

confidence: 98%

Section: Binding Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Atrial natriuretic peptide and aldosterone secretions, and atrial natriuretic peptide-binding sites in kidneys and adrenal glands of pregnant and fetal rats in late gestation in response to a high-salt diet

Deloof

Seze

Montel

et al. 2000

European Journal of Endocrinology

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“…Two types of ANP receptors have been identi®ed. The ®rst type, mainly demonstrated in the kidneys and adrenals, 23 are functional receptors which activate the particulate guanylate cyclase, 24 with intra cellular accumulation of cyclic GMP. The second receptor type removes ANP from the circulation and is known as a clearance receptor.…”

Section: Discussionmentioning

confidence: 99%

Impairment of antidiuretic hormone and atrial natriuretic peptide regulation in the obese woman with a swelling syndrome and an increase in capillary permeability to albumin

et al. 1997

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OBJECTIVE: To study the regulation of antidiuretic hormone (ADH) and atrial natriuretic peptide (ANP) in obese and lean women with a swelling syndrome. PATIENTS: Thirty-four obese women and 12 lean women with a swelling syndrome and an abnormal isotopic test of capillary permeability to albumin were investigated. MEASUREMENTS: After 10 nocturnal hours of¯uid restriction, subjects were asked at 8 am to ingest a tap water load of 20 ml/kg within 10 min and to remain strictly recumbent until twelve noon on the ®rst day, and to remain standing and to walk around until twelve noon on the second day. Free water clearance and the cGMP/creatinine and albumin/ creatinine ratios were determined hourly in the morning. RESULTS: The total 4 h-urinary volume/ingested water volume ratio was signi®cantly lower on the second day both in the lean and the obese patients, the differences being slightly larger in the obese patients. The increase in free water clearance was signi®cantly less on the second day in the obese patients. The increase in cGMP/creatinine ratio was also signi®cantly lower on the second day in the obese patients. The maximum level of the urinary albumin/creatinine ratio was signi®cantly higher on the second day in the obese patients. CONCLUSION: In obese women with a swelling syndrome: (1) The higher increase in the urinary albumin excretion rate after water loading followed by a sustained upright position suggests a widespread alteration in capillary function, which is also indicated by the isotopic test of capillary permeability to albumin. (2) The water load-induced inhibition of ADH secretion and stimulation of ANP secretion or ANP activity, more defective in the upright position than in the recumbent one, is probably another major contributing factor to orthostatic oedema.

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“…the prohormone is stored in secretory vesicles. ANF-126 is further processed enzymatically and secreted into the blood, where the biologically active C-terminal ANF-28 has been defined as the circulating hormone [27,35,36]. Increased dietary sodium intake has been shown to stimulate ANF release [37].…”

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confidence: 99%

Atrial natriuretic factor

1987

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Biologically active atrial peptides.

Cited by 217 publications

References 100 publications

Atrial natriuretic peptide and aldosterone secretions, and atrial natriuretic peptide-binding sites in kidneys and adrenal glands of pregnant and fetal rats in late gestation in response to a high-salt diet

Atrial natriuretic peptide and aldosterone secretions, and atrial natriuretic peptide-binding sites in kidneys and adrenal glands of pregnant and fetal rats in late gestation in response to a high-salt diet

Impairment of antidiuretic hormone and atrial natriuretic peptide regulation in the obese woman with a swelling syndrome and an increase in capillary permeability to albumin

Atrial natriuretic factor

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