Biologically Active Compounds with Antitumor Activity in Propolis Extracts from Different Geographic Regions

Slavov, Anton; Trifonov, Atanas; Peychev, Lyudmil; Dimitrova, Stela; Peycheva, Stela; Gotcheva, Velitchka; Angelov, Angel

doi:10.5504/bbeq.2013.0034

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…In this study, Rutin cannot be quantified; probably due to the interference with other similar compounds (like saccharide derivatives) (Coneac et al, 2008) . In addition, Slavova et al (2013) reported presence of rutin in half only of analyzed samples with better results for commercial products than for propolis extracts obtained in the laboratory.…”

Section: Resultsmentioning

confidence: 99%

A Comparative Study on Propolis and Pollen Extracts: Chemical Profile Analysis, Antioxidant and Anticancer Activity

Shady¹,

Mohamed²,

Sayed-Ahmed³

et al. 2016

Int.J.Curr.Microbiol.App.Sci

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Section: Resultsmentioning

confidence: 99%

A Comparative Study on Propolis and Pollen Extracts: Chemical Profile Analysis, Antioxidant and Anticancer Activity

Shady¹,

Mohamed²,

Sayed-Ahmed³

et al. 2016

Int.J.Curr.Microbiol.App.Sci

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“…In addition, CAPE, a phenolic acid present in propolis of various geographical origins, is associated with significant chemoprotective and anticancer properties [ 33 , 65 , 66 , 67 ], including against melanoma cells [ 68 ]. Acacetin identified in subfractions I and K exhibited anticancer effects in diverse types of cancer such as breast cancer, lung cancer, prostate cancer, and colon cancer [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Phenolic Compounds Contribution to Portuguese Propolis Anti-Melanoma Activity

et al. 2023

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Melanoma is the deadliest type of skin cancer, with about 61,000 deaths annually worldwide. Late diagnosis increases mortality rates due to melanoma’s capacity to metastasise rapidly and patients’ resistance to the available conventional therapies. Consequently, the interest in natural products as a strategy for drug discovery has been emerging. Propolis, a natural product produced by bees, has several biological properties, including anticancer effects. Propolis from Gerês is one of the most studied Portuguese propolis. Our group has previously demonstrated that an ethanol extract of Gerês propolis collected in 2018 (G18.EE) and its fractions (n-hexane, ethyl acetate, and n-butanol) decrease melanoma cell viability. Out of all the fractions, G18.EE-n-BuOH showed the highest potential as a melanoma pharmacological therapy. Thus, in this work, G18.EE-n-BuOH was fractioned into 17 subfractions whose effect was evaluated in A375 BRAF-mutated melanoma cells. The subfractions with the highest cytotoxic activity were analysed by UPLC-DAD-ESI/MSn in an attempt to understand which phenolic compounds could account for the anti-melanoma activity. The compounds identified are typical of the Gerês propolis, and some of them have already been linked with antitumor effectiveness. These results reaffirm that propolis compounds can be a source of new drugs and the isolation of compounds could allow its use in traditional medicine.

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“…Betalain bersifat larut air, kaya akan nitrogen dan menghasilkan warna kemerahan sehingga potensial dijadikan sebagai pewarna natural dalam produk pangan. Pigmen betalain dapat dijadikan sebagai alternatif pewarna antosianin yang terkandung pada jenis buah lain karena stabilitas dan resistensi betalain terhadap pengaruh pH dan suhu lebih baik terutama pada pH asam rendah (Slavov et al, 2013).…”

Section: Karakterisasi Tepung Buah Bitunclassified

KARAKTERISASI DAN SKRINING FITOKIMIA DARI TEPUNG BUAH BIT (Beta vulgaris L.)

Maimunah

Amila

Marpaung

et al. 2021

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Buah bit (Beta vulgaris L.) merupakan tanaman yang banyak mengandung senyawa betalain. sumber utama pewarna merah alami. Salah satu inovasi pemanfaatan buah bit yaitu pembuatan tepung bit. Tujuan penelitian ini adalah mengetahui karakterisasi dan skrining fitokimia umbi bit, serta mengetahui tingkat penerimaan umbi bit yang dijadikan tepung bit bagi para panelis. Penelitian ini merupakan eksperimental dengan menguji kandungan senyawa kimia melalui uji karakterisasi dan skrining fitokimia. Hasil penelitian menunjukkan bahwa tepung bit (Beta vulgaris L.) memiliki senyawa alkaloid, tanin, saponin, flavanoid, steroid, glikosida gula, dan polifenol. Uji Organoleptik dilakukan oleh 20 panelis, dengan kriteria penilaian sebanyak 9 panelis menyukai rasa, 6 panelis menyukai aroma, 12 panelis menyukai warna merah maroon, 12 panelis menyukai tekstrur, dan 11 panelis memiliki daya terima untuk tepung bit.

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Biologically Active Compounds with Antitumor Activity in Propolis Extracts from Different Geographic Regions

Cited by 6 publications

References 20 publications

A Comparative Study on Propolis and Pollen Extracts: Chemical Profile Analysis, Antioxidant and Anticancer Activity

A Comparative Study on Propolis and Pollen Extracts: Chemical Profile Analysis, Antioxidant and Anticancer Activity

Phenolic Compounds Contribution to Portuguese Propolis Anti-Melanoma Activity

KARAKTERISASI DAN SKRINING FITOKIMIA DARI TEPUNG BUAH BIT (Beta vulgaris L.)

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