Biologically Active Quassinoids and Their Chemistry: Potential Leads for Drug Design

Guo, Zhenghong; Vangapandu, Suryanarayana; Sindelar, Robert W.; Walker, Larry; Sindelar, Robert D.

doi:10.2174/0929867053363351

Cited by 154 publications

(132 citation statements)

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“…The major quassinoids are quassin, neoquassin, 18-hydroxyquassin, simalikalactone D, picrasin, and quassimarin. Most quassinoids have a C-20 structure, but simalikalactone D has a C-25 structure and quassimarin has a C-27 structure [61,62]. The plant also contains indolic alkaloids of the β-carboline family such as 1-vinyl-4,8-dimethoxy-β-carboline, 1-methoxycarbonyl-β-carboline, and 3-methylcanthine-2,6-dione [63].…”

Section: Constituentsmentioning

confidence: 99%

Revisiting Amazonian Plants for Skin Care and Disease

Burlando

Cornara

2017

Cosmetics

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Abstract:This review concerns five species of trees and palm trees that occur as dominant plants in different rainforest areas of the Amazon region. Due to their abundance, these species can be exploited as sustainable sources of botanical materials and include Carapa guianensis Aubl., family Meliaceae; Eperua falcata Aubl., family Fabaceae; Quassia amara L., family Simaroubaceae; and Attalea speciosa Mart. and Oenocarpus bataua Mart., family Arecaceae. For each species, the general features, major constituents, overall medicinal properties, detailed dermatological and skin care applications, and possible harmful effects have been considered. The major products include seed oils from A. speciosa and C. guianensis, fruit oil from O. bataua, and active compounds such as limonoids from C. guianensis, flavonoids from E. falcata, and quassinoids from Q. amara. The dermatologic and cosmetic applications of these plants are growing rapidly but are still widely based on empiric knowledge. Applications include skin rehydration and soothing; anti-inflammatory, antiage, and antiparasite effects; hair care; burn and wound healing; and the amelioration of rosacea and psoriasis conditions. Despite a limited knowledge about their constituents and properties, these species appear as promising sources of bioactive compounds for skin care and health applications. An improvement of knowledge about their properties will provide added value to the exploitation of these forest resources.

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Section: Constituentsmentioning

confidence: 99%

Revisiting Amazonian Plants for Skin Care and Disease

Burlando

Cornara

2017

Cosmetics

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“…The anti-cell activity of liriodenine from Liriodendron tulipifera has been shown to have effects on human melanoma A375.S2 cells (Chiu et al, 2012). Cell growth inhibition activity of liriodenine demonstrated a potent cytotoxicity against KB, A-549, HCT-8, P-388 and L-1210 cells with IC 50 values of 3.6, 2.6, 2.5, 2.1, and 8.5 µM, respectively (Guo et al, 2005).…”

Section: Antitumor Activitymentioning

confidence: 99%

Review on pharmacological activities of liriodenine

Chen¹

2013

Afr. J. Pharm. Pharmacol.

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“…Eurycoma longifolia Jack contains quassinoids such as 14, 15-dihydroxy-klaineanone, eurycomanone, 13, 21-dihydro-eurycomanone, 13α (21)-epoxy-eurycomanone, 14,15 βdihydroxy-klaineanone, longilactone and eurycomalactone (Han et al, 2015), eurycomanol, eurycomanol-2-O-β-D-glucopyranoside (Teh et al, 2011), alkaloids, glycosides (Bhat and Karim, 2010), glycoproteins (Sambandan et al, 2006), biophenylneolignans, triterpenes, canthine-6-one and β-carboline (Guo et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Kinetic Motilities of Cryopreserved Bull Spermatozoa: Owing to the Effect of <i>Eurycoma longifolia</i> Jack Aqueous Extract

Baiee¹,

Wahid²,

Yusoff³

et al. 2017

American Journal of Animal and Veterinary Sciences

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This study was carried out to improve the kinetic motilities of frozen-thawed bull semen diluted with tris-based egg yolk diluent that was supplemented with Eurycoma longifolia jack aqueous extract. A total of 24 ejaculates were obtained from six cross-bred bulls using an electro-ejaculator. The extract of Eurycoma longifolia jack was distributed into three low doses and three high doses; cryopreserved samples were evaluated into three different times to confirm the results of kinetic motilities through different times and between groups. Path velocity (VAP µm/s), progress velocity (VSL µm/s), track speed (VCL µm/s), lateral amplitude (ALH µm/s), Beat Frequency (BCF Hz), straightness (STR %), linearity (LIN %), were evaluated three different times using Computer-assisted sperm analysis. Results revealed that the percentage of VAP, ASL and VCL were higher (p<0.05) in the frozen-thawed semen group supplemented with 5 mg mL .54 in third evaluation; respectively). In conclusion, Eurycoma longifolia Jack aqueous extract supplementation to the semen diluent at 5 mg mL −1 significantly improved sperm kinetic motilities of frozen-thawed bull semen.

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Biologically Active Quassinoids and Their Chemistry: Potential Leads for Drug Design

Cited by 154 publications

References 1 publication

Revisiting Amazonian Plants for Skin Care and Disease

Revisiting Amazonian Plants for Skin Care and Disease

Review on pharmacological activities of liriodenine

Kinetic Motilities of Cryopreserved Bull Spermatozoa: Owing to the Effect of <i>Eurycoma longifolia</i> Jack Aqueous Extract

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