Biologically Active Substances from European Guelder Berry Fruits

Перова, И Б; Жогова, А. А.; Cherkashin, Artemiy; Эллер, К И; Ramenskaya, G. V.; Самылина, И. А.

doi:10.1007/s11094-014-1105-8

Cited by 57 publications

(74 citation statements)

References 7 publications

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“…This ratio can be used in the control of drugs based on viburnum fruits. According to the study, 5 the ratio of glucose: fructose in samples of fresh viburnum fruits is 1.0-1.5; our findings for dried fruits fall within this range. The profile and content of monomeric sugars, along with other BAS groups, can serve as indicators of identity and good quality when standardizing dried, fresh, freshly frozen viburnum fruits, drugs, extracts, and dietary supplements based on it.…”

Section: Resultssupporting

confidence: 66%

“…Viburnum fruits contain a large variety of biologically active substances (BAS) [5][6][7][8][9][10] : anthocyanins, proanthocyanidins [11][12][13] , flavonoids, hydroxycinnamic acids, iridoids, polysaccharides, organic acids 14,15 , lipids 16 , aromatic components. 17 The raw material contains a unique vitamin complex: ascorbic, nicotinic acid, vitamin A, vitamin K, folic acid, tocopherol; micro-and macro-elements: molybdenum, magnesium, selenium, copper, manganese, zinc, iron, chromium, potassium, cobalt, calcium.…”

Section: Introductionmentioning

confidence: 99%

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Determination of Sugar Profile in Viburnum Fruits and its Dosage Forms by HPLC-RID

Sergunova¹,

Ai²,

Sl³

et al. 2020

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Background: In the Russian Federation, the viburnum fruits are used to obtain infusions and syrups as medications. This medicinal herbal raw material contains a large number of biologically active substances: vitamins, anthocyanins, proanthocyanidins, flavonoids, hydroxycinnamic acids, iridoids, carbohydrates, organic acids, lipids etc. The research aimed to study one of the biologically active substances group responsible for the formation of the organoleptic properties of aqueous extracts-monomeric carbohydrate composition and content. Materials and methods: Dried viburnum (guelder-rose) fruits, an aqueous infusion based on it, and viburnum syrup of industrial manufacture (Russia) were purchased from the pharmacy and prepared for research. For HPLC analysis of monomeric sugars Agilent 1260 Series HPLC system equipped with autosampler/injector, four-channel gradient pump, column thermostat, refractive index detector), software (ChemStation Version B.01), column (Waters Sugar-Pack I, 10 μm, 300 × 6.5 mm) were used. Isocratic elution was performed using purified water (with the addition of Ca-EDTA 0.05 mg/ml) as the mobile phase, at a flow rate of 0.5 mL/min. The column was maintained at 80 °C, the refractive index detector-at 35 °C. The injection volume was 10 μL, analysis time-20 min. Results: The main free carbohydrates of viburnum fruits and preparations based on them are glucose, fructose, and sucrose. The total content of simple sugars in the viburnum fruits is 28.393 ± 0.528%, in the infusion-0.499 ± 0.015%, in the syrup-69.736 ± 1.551%. The characteristic ratio of glucose: fructose: sucrose in dried viburnum fruits is 8.1:5.4:1, in infusion-7.0:5.7:1, and in syrup-9.2:8.8:1. The sugars' degree of passing into infusion is 74.34%. Conclusion: The composition and content of carbohydrates determined by HPLC-RID are an important characteristic data. It can be used for viburnum fruits Russian pharmacopoeial standardization along with the quantifying total content of organic acids.

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Section: Resultssupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Determination of Sugar Profile in Viburnum Fruits and its Dosage Forms by HPLC-RID

Sergunova¹,

Ai²,

Sl³

et al. 2020

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“…Secoiridoids are believed to be even more advanced due to the more complicated biostynthetic steps (Xiang et al, 1996). Thus, the most closely related in the iridoids transformation pathway compounds, such as loganin ( 1 ), loganic acid ( 3 ), cornin ( 4 ), sweroside ( 5 ), and representative of secoiridoids, cornuside ( 6 ), have been detected both in fruits of C. mas and C. officinalis (Deng et al, 2013; Ma et al, 2014; Perova et al, 2014; Sochor et al, 2014; Kucharska et al, 2015; Jiang et al, 2016). However, it should be noted that in the 26 cultivars of C. mas it was shown that the most abundant iridoid was loganic acid ( 3 ) (81.5–461.1 mg/100 g fw) constituting 88–96% of total iridoids (86.9–493.7 mg/100 g fw).…”

Section: Similarities and Differences In The Chemical Composition Of mentioning

confidence: 99%

“…Cornuside ( 6 ) has already followed loganic acid ( 3 ) but its content was much lower than loganic acid ( 3 ) and maximally reached 36.2 mg/100 g fw (West et al, 2012a; Kucharska et al, 2015). Only two reports describe the identification of loganin ( 1 ) and sweroside ( 5 ) in fruit of C. mas (Deng et al, 2013; Perova et al, 2014). Nevertheless, the reason of limited data on identification of loganin and sweroside in fruits of cornelian cherry is due to their low concentration compared to loganic acid.…”

Section: Similarities and Differences In The Chemical Composition Of mentioning

confidence: 99%

“…The most abundant monosaccharide components of these polysaccharides were glucose, rhamnose and arabinose (Yang et al, 2010; Li et al, 2012). The monosaccharide profile of C. mas fruits have been represented by glucose, fructose and sucrose (Bilejić et al, 2011; Perova et al, 2014; Tarko et al, 2014; Antolak et al, 2017). …”

Section: Similarities and Differences In The Chemical Composition Of mentioning

confidence: 99%

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Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Czerwińska

Melzig

2018

Front. Pharmacol.

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Among 65 species belonging to the genus Cornus only two, Cornus mas L. and Cornus officinalis Sieb. et Zucc. (Cornaceae), have been traditionally used since ancient times. Cornus mas (cornelian cherry) is native to southern Europe and southwest Asia, whereas C. officinalis (Asiatic dogwood, cornel dogwood) is a deciduous tree distributed in eastern Asia, mainly in China, as well as Korea and Japan. Based on the different geographic distribution of the closely related species but clearly distinct taxa, the ethnopharmacological use of C. mas and C. officinalis seems to be independently originated. Many reports on the quality of C. mas fruits were performed due to their value as edible fruits, and few reports compared their physicochemical properties with other edible fruits. However, the detailed phytochemical profiles of C. mas and C. officinalis, in particular fruits, have never been compared. The aim of this review was highlighting the similarities and differences of phytochemicals found in fruits of C. mas and C. officinalis in relation to their biological effects as well as compare the therapeutic use of fruits from both traditional species. The fruits of C. mas and C. officinalis are characterized by the presence of secondary metabolites, in particular iridoids, anthocyanins, phenolic acids and flavonoids. However, much more not widely known iridoids, such as morroniside, as well as tannins were detected particularly in fruits of C. officinalis. The referred studies of biological activity of both species indicate their antidiabetic and hepatoprotective properties. Based on the available reports antihyperlipidemic and anticoagulant activity seems to be unique for extracts of C. mas fruits, whereas antiosteoporotic and immunomodulatory activities were assigned to preparations of C. officinalis fruits. In conclusion, the comparison of phytochemical composition of fruits from both species revealed a wide range of similarities as well as some constituents unique for cornelian cherry or Asiatic dogwood. Thus, these phytochemicals are considered the important factor determining the biological activity and justifying the use of C. mas and C. officinalis in the traditional European and Asiatic medicine.

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Natural compounds against nonalcoholic fatty liver disease: A review on the involvement of the LKB1/AMPK signaling pathway

Omidkhoda,

Mahdiani,

Hayes

et al. 2023

Phytotherapy Research

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Although various therapeutic approaches are used to manage nonalcoholic fatty liver disease (NAFLD), the best approach to NAFLD management is unclear. NAFLD is a liver disorder associated with obesity, metabolic syndrome, and diabetes mellitus. NAFLD progression can lead to cirrhosis and end‐stage liver disease. Hepatic kinase B1 (LKB1) is an upstream kinase of 5′‐adenosine monophosphate‐activated protein kinase (AMPK), a crucial regulator in hepatic lipid metabolism. Activation of LKB1/AMPK inhibits fatty acid synthesis, increases mitochondrial β‐oxidation, decreases the expression of genes encoding lipogenic enzymes, improves nonalcoholic steatohepatitis, and suppresses NAFLD progression. One potential opening for new and safe chemicals that can tackle the NAFLD pathogenesis through the LKB1‐AMPK pathway includes natural bioactive compounds. Accordingly, we summarized in vitro and in vivo studies regarding the effect of natural bioactive compounds such as a few members of the polyphenols, terpenoids, alkaloids, and some natural extracts on NAFLD through the LKB1/AMPK signaling pathway. This manuscript may shed light on the way to finding a new therapeutic agent for NAFLD management.

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Biologically Active Substances from European Guelder Berry Fruits

Cited by 57 publications

References 7 publications

Determination of Sugar Profile in Viburnum Fruits and its Dosage Forms by HPLC-RID

Determination of Sugar Profile in Viburnum Fruits and its Dosage Forms by HPLC-RID

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Natural compounds against nonalcoholic fatty liver disease: A review on the involvement of the LKB1/AMPK signaling pathway

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