Biologics combined with conventional systemic agents for the treatment of children with severe psoriasis. Real‐life data from the BiPe cohorts and a practice survey among French and Italian pediatric dermatologists

Abstract

Combined therapies involve the use of multiple drugs to increase efficacy and reduce the toxicity of individual treatments. We evaluated the use of combinations of conventional systemic therapies and biologics in children with psoriasis in daily practice.This two-part study used data from the 170 children in the Franco-Italian BiPe cohorts to evaluate the use, efficacy, and safety of combined conventional systemicbiologic therapies, and from a survey carried out among French and Italian dermatologists to better understand the reasons for using or avoiding these combinations. In

Effectiveness of biologic therapies in children with palmoplantar plaque psoriasis: An analysis of real‐life data from the BiPe cohorts

“…The frequency of palmoplantar plaque psoriasis in the study population, 11.8% of the children receiving biologic therapies, was in the range generally reported in previous publications of psoriasis patients treated in hospital settings, 5%–18% 16–19 . This study also provided information on the clinical and demographic features of this form of psoriasis in children.…”

“…The frequency of palmoplantar plaque psoriasis in the study population, 11.8% of the children receiving biologic therapies, was in the range generally reported in previous publications of psoriasis patients treated in hospital settings, 5%-18%. [16][17][18][19] This study also provided information on the clinical and demographic features of this form of psoriasis in children. Compared to generalized plaque psoriasis, we found that palmoplantar plaque psoriasis affected younger children, tended to be more common in males, and was more frequently associated with nail involvement.…”

“…16 In a recent study evaluating the use of combined therapies in two cohorts of children with psoriasis receiving biologic therapies (Biological treatments for Pediatric Psoriasis (BiPe) cohorts-BiPe and BiPe Jr), 4,5 we noted that palmoplantar plaque psoriasis was overrepresented in the group of patients using a combination of conventional systemic treatments and biologic therapy. 17 The main objective of this study was to use data from the BiPe cohorts to evaluate the effectiveness of biologic therapies for managing palmoplantar plaque psoriasis, compared to classic, generalized plaque psoriasis. Disease epidemiology and patient demographic and clinical characteristics were also evaluated.…”

“…In a recent study evaluating the use of combined therapies in two cohorts of children with psoriasis receiving biologic therapies (Biological treatments for Pediatric Psoriasis (BiPe) cohorts—BiPe and BiPe Jr), 4,5 we noted that palmoplantar plaque psoriasis was over‐represented in the group of patients using a combination of conventional systemic treatments and biologic therapy 17 …”