Bioluminescence microscopy for cellular level circadian analysis in the suprachiasmatic nucleus

Kammerloher, Werner

doi:10.1038/nmeth.f.226

Cited by 5 publications

(3 citation statements)

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“…BLI is primarily used in experimental breast cancer research for imaging gene expression, therapy evaluation (Kalra et al 2009;Shah et al 2008;Szafran et al 2009;Viola et al 2008;Wang et al 2009), or for imaging peroxidase activity in vivo (Chen et al 2004;Gross et al 2009). Bioluminescence microscopy is a recently emerging technology and is now gaining increasing interest among cell biologists for its ability to image cells under low light, eliminating the need for fluorescent molecules (Kammerloher 2008).…”

Section: Macroscopic Imaging Technologiesmentioning

confidence: 99%

Molecular Imaging in Cancer

Weissleder

2006

Science

1,023

820

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Medical imaging technologies have undergone explosive growth over the past few decades and now play a central role in clinical oncology. But the truly transformative power of imaging in the clinical management of cancer patients lies ahead. Today, imaging is at a crossroads, with molecularly targeted imaging agents expected to broadly expand the capabilities of conventional anatomical imaging methods. Molecular imaging will allow clinicians to not only see where a tumor is located in the body, but also to visualize the expression and activity of specific molecules (e.g., proteases and protein kinases) and biological processes (e.g., apoptosis, angiogenesis, and metastasis) that influence tumor behavior and/or response to therapy. This information is expected to have a major impact on cancer detection, individualized treatment, and drug development, as well as our understanding of how cancer arises.

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Section: Macroscopic Imaging Technologiesmentioning

confidence: 99%

Molecular Imaging in Cancer

Weissleder

2006

Science

1,023

820

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Section: Macroscopic Imaging Technologiesmentioning

confidence: 99%

In Vivo Imaging in Cancer

Condeelis¹,

Weissleder²

2010

Cold Spring Harbor Perspectives in Biology

213

157

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Imaging has become an indispensable tool in the study of cancer biology and in clinical prognosis and treatment. The rapid advances in high resolution fluorescent imaging at single cell level and MR/PET/CT image registration, combined with new molecular probes of cell types and metabolic states, will allow the physical scales imaged by each to be bridged. This holds the promise of translation of basic science insights at the single cell level to clinical application. In this article, we describe the recent advances in imaging at the macro-and micro-scale and how these advances are synergistic with new imaging agents, reporters, and labeling schemes. Examples of new insights derived from the different scales of imaging and relevant probes are discussed in the context of cancer progression and metastasis.

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“…Bioluminescence imaging, like fluorescence imaging, also belongs to optical molecular imaging, is both highly sensitive (with picomolar sensitivity) and highly specific (clean of background signal) for tumor detection [3][4][5][6][7] , indicating great potential for in vivo early or metastatic tumor detection. Several commercial bioluminescence imaging systems have been developed and already play an indispensable role in propelling basic and translational research [8][9][10][11] . Despite of its advantage in sensitivity and specificity, there are Our team has developed a multimodality research platform, namely XXX, which integrates x-ray CT, optical tomography, and radiation therapy [12][13][14][15][16][17] .…”

Section: Introductionmentioning

confidence: 99%