2024
DOI: 10.1177/10591478241270130
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Biomanufacturing Harvest Optimization With Small Data

Bo Wang,
Wei Xie,
Tugce Martagan
et al.

Abstract: In biopharmaceutical manufacturing, fermentation processes play a critical role in productivity and profit. A fermentation process uses living cells with complex biological mechanisms, leading to high variability in the process outputs, namely, the protein and impurity levels. By building on the biological mechanisms of protein and impurity growth, we introduce a stochastic model to characterize the accumulation of the protein and impurity levels in the fermentation process. However, a common challenge in the … Show more

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