Biomarker-Based Targeted Therapeutics

Hora, Shainan; Pandey, Amit Kumar; Jha, Sudhakar

doi:10.5772/intechopen.78377

Cited by 4 publications

(6 citation statements)

References 201 publications

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“…It ranks second after heart disease in the list of causes of death. Surgical procedures, chemotherapy and radiotherapy are widely used in cancer treatment (Hora et al., 2018; Li & Xiong, 2011). However, these treatments have many side effects and these side effects reduce the quality of life of patients.…”

Section: Discussionmentioning

confidence: 99%

Effect of imipramine on ether à‐go‐go potassium channel (Kv1.10) expression in DU145 prostate cancer cells

et al. 2021

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In recent studies, it has been reported that ion channels play an important role in cancer formation. Therefore, it is possible that the use of pharmacological agents targeting ion channels will allow the development of new strategies for cancer treatment. In this study, we investigate the effect of imipramine on Eag1 channel expression in DU145 prostate cancer cells. Culture cells were divided into 4 groups as the control, 10, 50 and 75 µM imipramine. Eag1 channel currents and conductivity were determined by whole‐cell patch‐clamp technique and gene expression by real time‐polymerase chain reaction (RT‐PCR). Current records were taken before (at 0th minute, as control) and 10 min after imipramine administration to the cells. It was observed that all three doses of imipramine significantly reduced Eag1 currents and conductivity compared with the control. However, the differences between dose groups were not significant. Similarly, Eag1 channel protein expression was found to be significantly reduced for all three doses of imipramine compared with the control group, but there was no significant difference in gene expression between dose groups. Obtained results suggested that imipramine has the potential to be used as a pharmacological agent targeting the Eag1 channel in the treatment of prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Effect of imipramine on ether à‐go‐go potassium channel (Kv1.10) expression in DU145 prostate cancer cells

et al. 2021

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“…However, because they are secreted in body fluids, some miRNAs are promising candidates for biomarker research. In comparison to mRNA expression signatures, miRNA signatures are shown to have more predictive power [ 20 , 21 ]. In ovarian physiology Deregulation of miRNA in OC is an important feature for its regulation.…”

Section: Non-coding Rna As Cancer Biomarkersmentioning

confidence: 99%

“…For instance, 39 miRNAs in tumor tissues are remarkably deregulated in contrast to the normal ovary, out of which the overexpressed miRNAs are miR-141, miR-200a, miR200c, and miR200b on the other hand down-regulated miRNAs were miR-199a, miR-140, miR-145 and miR-125b1 [ 22 ]. The emphasis on miRNA networks in EOC survival is shown in various studies which conclude that eight miRNAs (miR-101, miR-141, miR-506, miR-25, miR-29c, miR-182, miR-128, and miR-200a) that were downregulated were predicted to regulate the majority of miRNA-associated genes [ 20 , 21 , 23 ]. Table 1 describes the Summary of some of the few miRNAs involved in epithelial ovarian cancer their expression and clinical features.…”

Section: Non-coding Rna As Cancer Biomarkersmentioning

confidence: 99%

Role of different non-coding RNAs as ovarian cancer biomarkers

et al. 2022

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Background Among many gynecological malignancies ovarian cancer is the most prominent and leading cause of female mortality worldwide. Despite extensive research, the underlying cause of disease progression and pathology is still unknown. In the progression of ovarian cancer different non-coding RNAs have been recognized as important regulators. The biology of ovarian cancer which includes cancer initiation, progression, and dissemination is found to be regulated by different ncRNA. Clinically ncRNA shows high prognostic and diagnostic importance. Results In this review, we prioritize the role of different non-coding RNA and their perspective in diagnosis as potential biomarkers in the case of ovarian cancer. Summary of some of the few miRNAs involved in epithelial ovarian cancer their expression and clinical features are being provided in the table. Also, in cancer cell proliferation, apoptosis, invasion, and migration abnormal expression of piRNAs are emerging as a crucial regulator hence the role of few piRNAs is being given. Both tRFs and tiRNAs play important roles in tumorigenesis and are promising diagnostic biomarkers and therapeutic targets for cancer. lncRNA has shown a leading role in malignant transformation and potential therapeutic value in ovarian cancer therapy. Conclusions Hence in this review we demonstrated the role of different ncRNA that play an important role in serving strong potential as a therapeutic approach for the treatment of ovarian cancer.

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“…Wilson's indisposition has an estimated prevalence of 1 in 30,000; however it's far higher in china, japan, and Sardinia in Italy [3]. WD is characterized through copper accumulation in the body [13], especially inside the liver and the mind [1]. It is because of mutation of the ATP7B gene that leads to dysfunction of the copper-transported enzyme P-kind ATPase [28], this enzyme is liable for transported copper into bile and incorporating it into ceruloplasmin [25].…”

Section: Wilson's Disordermentioning

confidence: 99%

“…Obesity is a form in which there is fat collection of body overweight or adipose tissue. This accumulation happens in lean body mass of muscles and unlike connective tissue [1,2]. Weight loss is an order in which there is loss of gathering body fat or adipose tissue from lean body mass [3].…”

Section: Introductionmentioning

confidence: 99%

How Obesity Affects Our Health

Iqbal¹,

Ullah²,

Masood³

et al. 2019

Natl. j. health sci.

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Introduction: Obesity is a form in which there is fat collection of body overweight or adipose tissue. This accumulation happens in lean body mass of muscles and unlike connective tissue. Obesity is consummate constantly defined by the body mass index (BMI), a mathematically formula of weight-for-height index. BMI has a high interaction with adiposity and it interacts well with fat weight at the population rank. Obesity is defined as abnormal all excessive accumulation that may be harmful to health. Although, its etiology has been associated with and energy imbalance between calories consumed and calories expended, which is mainly as a result of a poor diet and insufficient physical exercise. Obesity is a worldwide epidemiologic syndrome depict by fat mass accumulation, mainly visceral fat. Obesity cause several diseases like genetic and metabolic issues, urea cycle problems, turner syndrome, Down syndrome, cystic fibrosis and Wilson's disease etc. Several factors are the cause of obesity like high sugar consumption but by taking some precautionary measures we can be secure from obesity.

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Biomarker-Based Targeted Therapeutics

Cited by 4 publications

References 201 publications

Effect of imipramine on ether à‐go‐go potassium channel (Kv1.10) expression in DU145 prostate cancer cells

Effect of imipramine on ether à‐go‐go potassium channel (Kv1.10) expression in DU145 prostate cancer cells

Role of different non-coding RNAs as ovarian cancer biomarkers

How Obesity Affects Our Health

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