Biomarker-Informed Machine Learning Model of Cognitive Fatigue from a Heart Rate Response Perspective

Lee, Kar Fye Alvin; Gan, Woon‐Seng; Christopoulos, George I.

doi:10.3390/s21113843

Cited by 13 publications

(10 citation statements)

References 138 publications

(217 reference statements)

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“…Cognitive fatigue is a psychological state characterized by the subjective feelings of tiredness, and impaired ability to think, memorize, and concentrate. [ 30 , 31 ] Cognitive fatigue is strongly associated with CRF. Eight studies reported the efficacy of ginseng oral administration and ginseng injections on cognitive fatigue.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of ginseng oral administration and ginseng injections on cancer-related fatigue: A meta-analysis

Hou

Sun

et al. 2022

Medicine

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Background: Up to 90% of patients who are under the active treatment suffer from cancer-related fatigue (CRF). CRF can persist about 10 years after diagnosis and/or treatment. Accumulating reports support that ginseng and ginseng injections are both potential drugs for the treatment of CRF but few studies put them together for analysis. Methods: Two reviewers independently extracted data in 3 databases (PubMed, Cochrane Library and China National Knowledge Infrastructure) from their inception to May 24, 2021. The primary outcome was the effect of ginseng in alleviating CRF. The secondary outcome was ginseng in alleviating emotional or cognitive fatigue. Standardized mean difference (SMD) was employed. Results: Twelve studies were included to evaluate efficacy of ginseng oral administration and ginseng injections on CRF. The pooled SMD was 0.40 (95% confidence Interval [95% CI] [0.29–0.51], P < .00001). Six studies were included to evaluate efficacy of ginseng oral administration on CRF and the SMD was 0.29 (95% CI [0.15–0.42], P < .0001). The order was 2000 mg/d, 3000 mg/d, 1000 mg/d and placebo from high efficacy to low. Ten studies were included to evaluate efficacy of ginseng injections on CRF and the SMD was 0.74 (95% CI [0.59–0.90], P < .00001). Emotional fatigue was reported in 4 studies, ginseng oral administration in 2 and ginseng injections in 2. The pooled SMD was 0.12 (95% CI [−0.04 to 0.29], P = .15). Cognitive fatigue was reported in 4 studies focusing on ginseng injections and the SMD was 0.72 (95% CI [0.48–0.96], P < .00001). Conclusion: Ginseng can improve CRF. Intravenous injection might be better than oral administration. Ginseng injections may alleviate cognitive fatigue. No evidence was found to support that ginseng could alleviate emotional fatigue.

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Section: Resultsmentioning

confidence: 99%

Efficacy of ginseng oral administration and ginseng injections on cancer-related fatigue: A meta-analysis

Hou

Sun

et al. 2022

Medicine

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“…Since it has been shown that cognitive exertion has a negative carryover effects on physical performance 49 and that physiological states correlate with cognitive fatigue 50 , physiological measures during pain stimulation were also collected to examine possible subsequent effects. Therefore, during the main experiment, we continuously recorded physiological responses to stimuli from their left hand, such as skin conductance (EDA) and heart rate.…”

Section: Methodsmentioning

confidence: 99%

Cognitive exertion affects the appraisal of one’s own and other people’s pain

Riontino

Fournier

Lapteva

et al. 2023

Sci Rep

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Correctly evaluating others’ pain is a crucial prosocial ability. In both clinical and private settings, caregivers assess their other people’s pain, sometimes under the effect of poor sleep and high workload and fatigue. However, the effect played by such cognitive strain in the appraisal of others’ pain remains unclear. Fifty participants underwent one of two demanding tasks, involving either working memory (Experiment 1: N-Back task) or cognitive interference (Experiment 2: Stroop task). After each task, participants were exposed to painful laser stimulations at three intensity levels (low, medium, high), or video-clips of patients experiencing three intensity levels of pain (low, medium, high). Participants rated the intensity of each pain event on a visual analogue scale. We found that the two tasks influenced rating of both one’s own and others’ pain, by decreasing the sensitivity to medium and high events. This was observed either when comparing the demanding condition to a control (Stroop), or when modelling linearly the difficulty/performance of each depleting task (N-Back). We provide converging evidence that cognitive exertion affects the subsequent appraisal of one’s own and likewise others’ pain.

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“…Since it has been shown that cognitive exertion has a negative carryover effects on physical performance 9 and that physiological states correlate with cognitive fatigue 40 , physiological measures during pain stimulation were also collected to examine possible subsequent effects. Therefore, during the main experiment, we continuously recorded physiological responses to stimuli from their left hand, such as skin conductance (EDA) and heart rate.…”

Section: Methodsmentioning

confidence: 99%

Cognitive exertion affects the appraisal of one’s own and other people’s pain

Riontino

Fournier

Lapteva

et al. 2022

Preprint

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Evaluating correctly others' pain is a crucial prosocial ability, especially relevant for the healthcare system. In clinical settings, caregivers assess their patients' pain under high workload and fatigue, often while dealing with competing information/tasks. However, the effect played by such cognitive strain in the appraisal of others' pain remains unclear. Following embodied accounts that posit a shared representational code between self and others' states, it could be hypothesized that the representation of people's pain might be influenced by cognitive exertion similarly to first-hand experiences. Fifty participants underwent one of two demanding tasks, involving either working memory (Experiment 1: N-Back task) or cognitive interference (Experiment 2: Stroop task). After each task, participants were exposed to painful laser stimulations at three intensity levels (low, medium, high), or video-clips of patients experiencing three intensity levels of pain (low, medium, high). Participants rated the intensity of each pain event on a visual analogue scale. We found that the two tasks influenced rating of both one's own and others' pain, by decreasing the sensitivity to medium and high events. This was observed either when comparing the demanding condition to a control (Stroop), or when modelling linearly the difficulty/performance of each depleting task (N-Back). These effects were mirrored by the analysis of physiological responses (Heart Variability and Skin Conductance) evoked by one's own pain. We provide converging evidence that cognitive exertion affects the subsequent appraisal of one's own and likewise others' pain. Healthcare personnel should be aware that high workload might alter their cognitive abilities.

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Biomarker-Informed Machine Learning Model of Cognitive Fatigue from a Heart Rate Response Perspective

Cited by 13 publications

References 138 publications

Efficacy of ginseng oral administration and ginseng injections on cancer-related fatigue: A meta-analysis

Efficacy of ginseng oral administration and ginseng injections on cancer-related fatigue: A meta-analysis

Cognitive exertion affects the appraisal of one’s own and other people’s pain

Cognitive exertion affects the appraisal of one’s own and other people’s pain

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