Biomarker Profile in Off-Pump and On-Pump Coronary Artery Bypass Grafting Surgery in Low-Risk Patients

Castellheim, Albert; Hoel, Terje; Videm, Vibeke; Fosse, Erik; Pharo, Anne; Svennevig, Jan; Fiane, Arnt E.; Mollnes, Tom Eirik

doi:10.1016/j.athoracsur.2008.03.012

Cited by 41 publications

(41 citation statements)

References 42 publications

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“…Significantly decreased IL-12 lung tissue level has been found during warm ischemia and reperfusion in the course of human lung transplantation procedure [23]. Contradicting our results, Castellheim et al [8] noticed a significantly higher IL-12 level measured 60 minutes after institution of by-pass in on-pump CABG patients compared to the cytokine level at 90 min after induction of anesthesia in off-pump patients. Probably, the difference in the intensity of ischemia during AAA and CABG could explain such a distinction, but this has been not evaluated yet.…”

Section: R R R R Results Esults Esults Esults Esultssupporting

confidence: 63%

“…at the end of ischemia in the AAA patients and after 90 minutes of surgery in the SC patients, IL-12 remained at similar levels as preoperatively in both groups, and they were still significantly higher than in the HC group. The enhanced production and secretion of IL-12 as a response to surgical injury has been well documented in 44 patients undergoing coronary artery bypass graft (CABG) surgery [8]. Those authors reported the elevation of IL-12 after institution of bypass in the on-pump group, and 30 min after induction of anesthesia in the off-pump group in comparison with the level measured just after the induction of anesthesia.…”

Section: R R R R Results Esults Esults Esults Esultsmentioning

confidence: 77%

“…It is generally agreed that trauma, surgery and infection induce pro-inflammatory and anti-inflammatory responses that contribute to cytokine production and secretion followed by infiltration of inflammatory cells [8,9]. As far as IL-12 is concerned, increased synthesis and secretion have been shown in the course of infection and injury of trauma patients [10].…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

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Decreased serum level of IL-12 in the course of ischemia and reperfusion during abdominal aortic surgery

Jedynak

Mroczko²,

Siemiątkowski³

et al. 2011

Folia Histochem Cytobiol.

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Abstract:Abstract: Abstract: Abstract: Abstract: Ischemic-reperfusion injury (IRI) is defined as tissue damage, organ dysfunction or failure developed in the course of inflammatory response following ischemia and reperfusion (IR). Abdominal aortic aneurysm (AAA) repair required IR of distal parts of the body carries a risk of organ injury and postoperative mortality of between 4% and 12%. The aim of this study was the evaluation of IL-12 serum level during AAA repair in relation to IR. Blood samples were taken before surgery (Preop), before aortic unclamping (Pre-X off ), 90 min after unclamping (90 min-X off ) and 24 h after surgery (Postop) from 37 AAA patients; and before surgery (Preop), at 90 min of surgery (90 min-surg), at 180 min of surgery (180 min-surg) and 24 h after operation (stop) from ten patients scheduled for elective surgery of lumbar discopathy (SC); and once from ten healthy controls. IL-12 was measured using the ELISA technique. Preoperative IL-12 was higher in AAA (0.21 pg/ml) and SC (0.31 pg/ml) patients than in controls (0.05 pg/ml). A significant decrease in IL-12 (0.09 pg/ml) was observed at 90 min-X off in comparison to the preoperative value in AAA but not in the SC group. 24 h after surgery, IL-12 levels were still low in the AAA group (0.13 pg/ml), and nonsignificantly surpassed the preoperative value in the SC group (0.36 pg/ml). We conclude that operative injury was associated with increased IL-12 levels, and IR with decreased IL-12 levels. Diminished IL-12 during AAA repair might be associated with a higher risk of postoperative complications, but this needs further evaluation.

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Section: R R R R Results Esults Esults Esults Esultssupporting

confidence: 63%

Section: R R R R Results Esults Esults Esults Esultsmentioning

confidence: 77%

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

See 1 more Smart Citation

Decreased serum level of IL-12 in the course of ischemia and reperfusion during abdominal aortic surgery

Jedynak

Mroczko²,

Siemiątkowski³

et al. 2011

Folia Histochem Cytobiol.

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show abstract

“…Recently, Castellheim et al reported biomarker profiles using multiplex cytokine analysis comparing on-pump versus off-pump coronary artery bypass grafting, though they examined samples from induction of anesthesia to only 2 hours postoperatively. 12 In both their on and off pump groups 14 of 25 biomarkers analyzed had increased levels compared to baseline -eotaxin, TNF-α, IL-1Ra, IL-2R, IL-6, IL-8, IL-10, IP-10, IL-12, IL-15, monokine induced by IFN-γ (MIG), MCP-1, RANTES, and MIP-1β. In particular, serum levels of IL-6, IL-10, IL-15, MCP-1, and RANTES remained significantly elevated at the end of their 2 hour observation periodsimilar to findings in our study.…”

Section: Discussionmentioning

confidence: 99%

Early blood biomarkers predict organ injury and resource utilization following complex cardiac surgery

Kim

Arnaoutakis

Martin

et al. 2008

Journal of the American College of Surgeons

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Background-Patients undergoing complex cardiac surgery (thoracic aorta and valve) are at risk for organ failure and increased resource utilization. Neutrophil gelatinase-associated lipocalin (NGAL) has been found to be an early biomarker for renal injury. Multiplex cytokine immunoassays allow the evaluation of the early inflammatory response. We examined the relationship between early biomarker appearance (NGAL and multiplex cytokines) and organ injury and resource utilization.

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“…In particular, VEGF and MCP-1 are considered biochemical markers of endothelial activation. 26, 27 However, these chemokines have been poorly investigated in heart surgery. In the present study, when standard linear perfusion was used, a progressive rise in plasma MCP-1 was detected (peaking at ICU arrival) followed by a progressive fall, whereas when IABP-induced pulsatile perfusion was used, MCP-1 showed a slight fall at aortic de-clamping, thus suggesting a significant reduction of endothelial activation during cross-clamping, followed by a progressive increase in the subsequent time-course.…”

Section: Discussionmentioning

confidence: 99%

Pulsatile Cardiopulmonary Bypass With Intra-Aortic Balloon Pump Improves Organ Function and Reduces Endothelial Activation

Serraino

Marsico

Musolino

et al. 2012

Circ J

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Biomarker Profile in Off-Pump and On-Pump Coronary Artery Bypass Grafting Surgery in Low-Risk Patients

Cited by 41 publications

References 42 publications

Decreased serum level of IL-12 in the course of ischemia and reperfusion during abdominal aortic surgery

Decreased serum level of IL-12 in the course of ischemia and reperfusion during abdominal aortic surgery

Early blood biomarkers predict organ injury and resource utilization following complex cardiac surgery

Pulsatile Cardiopulmonary Bypass With Intra-Aortic Balloon Pump Improves Organ Function and Reduces Endothelial Activation

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