Biomarkers in Overactive Bladder

Abstract

Overactive bladder (OAB) remains a remarkably common urologic condition and results in significant clinical and economic sequelae. Although likely underestimated, the overall prevalence of OAB is projected to be between 15% and 38%. The diverse etiologies of this symptom complex have limited attempts to develop reproducible biological markers of disease. Recent advances in bladder and urothelial physiology have dramatically expanded our repertoire of potential markers for use in diagnosis and to monitor treatment. Herein we present an overview of several emerging options for OAB diagnosis and review the available literature regarding these prospective biomarkers. Despite intensive awareness into OAB diagnostics, we are witness to the genesis of exploration on detrusor function and urothelial biology that will guide interventions in the coming decades. Immense opportunity exists for future evaluation of OAB pathophysiology to advance our knowledge regarding management of this multifactorial urologic disorder and define biomarkers of the disease process.