Biomarkers in Urolithiasis

Hinojosa-González, David Eugenio; Eisner, Brian H.

doi:10.1016/j.ucl.2022.09.004

Cited by 3 publications

(4 citation statements)

References 80 publications

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“…For complications, both groups had comparable complications except for the pain score that was significantly higher in the narrow-vs the wide-focus group, with a median (IQR) score of 5 (3,6) vs 3 (2, 3) (P < 0.001). Also, highgrade haematuria (defined as Grade III) was significantly lower in the wide-focus group (P = 0.03; Table 3).…”

Section: Resultsmentioning

confidence: 92%

“…Post-SWL pain was higher in narrow-focus group compared to the wide-focus group, with a median (IQR) score of 5 (3,6) vs 3 (2, 3), which is mostly related to the different focal zones.…”

Section: Discussionmentioning

confidence: 89%

“…Kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are two of these biomarkers that have been recently confirmed to rise within the first few hours of acute kidney injury. These markers are, in contrary to creatinine which takes a long time to elevate, used as early predictors of renal damage after SWL [6,7].…”

Section: Introductionmentioning

confidence: 99%

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The effect of piezoelectric shockwave lithotripsy with 2‐ and 8‐mm focus sizes on stone disintegration and renal injury

et al. 2023

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ObjectivesTo compare the efficacy and safety of shockwave lithotripsy (SWL) using a narrow focus or wide focus for renal stones.Patients and MethodsA double‐blind randomised trial included adult patients with a solitary radio‐opaque renal pelvic stone of 1–2 cm. Patients were randomised into two groups: narrow‐focus (2 mm) SWL and wide‐focus (8 mm) SWL. The stone‐free rate (SFR) and presence of complications such as haematuria, fever, pain, and peri‐renal haematoma were evaluated. Pre‐ and postoperative urinary markers (neutrophil gelatinase‐associated lipocalin [NGAL] and kidney injury molecule 1 [KIM‐1]) concentrations were compared to assess renal injury.ResultsA total of 135 patients were recruited for this study. The SFR after the first SWL session was 79.2% and 69.1% in narrow‐ and wide‐focus groups, respectively. There was a comparable rise in the median 2‐h NGAL concentration in both groups (P = 0.62). However, the rise in the median (interquartile range [IQR]) 2‐h KIM‐1 concentration was significantly higher in the narrow‐focus group at 4.9 (4.6, 5.8) ng/mL compared with the wide‐focus group at 4.4 (3.2, 5.7) ng/mL (P = 0.02). Nevertheless, the 3‐day NGAL and KIM‐1 urinary marker concentrations were significantly improved (P = 0.263 and P = 0.963, respectively). The overall SFR after three sessions was 86.6% and 86.8% in the narrow‐ and wide‐focus groups, respectively (P = 0.77). Both groups were comparable for complications, apart from the median pain score and the percentage of high‐grade haematuria, which were significantly higher in the narrow‐focus group (P < 0.001 and P = 0.03, respectively).ConclusionNarrow‐ and wide‐focus SWL were associated with comparable outcomes and re‐treatment rates. However, narrow‐focus SWL was associated with significantly higher morbidity in terms of pain and haematuria.

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Section: Resultsmentioning

confidence: 92%

“…Post-SWL pain was higher in narrow-focus group compared to the wide-focus group, with a median (IQR) score of 5 (3,6) vs 3 (2, 3), which is mostly related to the different focal zones.…”

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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The effect of piezoelectric shockwave lithotripsy with 2‐ and 8‐mm focus sizes on stone disintegration and renal injury

et al. 2023

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“…Surgery can stimulate the production of oxygen-free radicals, thereby disrupting the body oxidative and antioxidant balance. [ 22 , 23 ] Clinically, the commonly monitored post-oxidative product is malondialdehyde (MDA), while superoxide dismutase (SOD) serves as an antioxidant; fluctuations in their levels can substantially reflect the degree of oxidative stress in the body. [ 24 ] Trauma can trigger neurological response systems and alter the secretion of many hormones, notably exemplified by elevated levels of cortisol (COR) and adrenocorticotropic hormone (ACTH).…”

Section: Discussionmentioning

confidence: 99%

The influence of perioperative nursing intervention in patients with ureteral calculi treated with URSL and its correlation to adverse event incidence: A retrospective study

Tang,

Zhu

2023

Medicine

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To evaluate the effectiveness of perioperative nursing intervention in patients undergoing ureteroscopic lithotripsy (URSL) for ureteral stones and its implications for the incidence of adverse events, a total of 144 patients with ureteral stones admitted to our hospital from January 2021 to December 2022 were selected for retrospective analysis. They were divided into 2 groups based on their different nursing methods, with 72 patients in each group. The control group (CG) received routine nursing intervention, while the study group (SD) received refined perioperative nursing intervention. The surgical situation, effective stone removal rate, postoperative pain, inflammatory factors, stress response, and incidence of adverse events were compared between the 2 groups. In comparison with the CG, the SD demonstrated a significant reduction in gastrointestinal recovery time, urinary catheter removal time, and hospitalization duration, all presenting statistically significant disparities (P < .05). Notably, the SD exhibited a one-time stone removal rate significantly superior to that of the CG (P < .05). Similarly, the postoperative pain index was significantly lower in the SD (P < .05). Pre- and post-surgical serotonin (5-HT) levels in the SD were markedly lower than in the CG (P < .05). Postoperative levels of Interleukin-10 (IL-10), C-reactive protein (CRP), and white blood cells (WBC) were elevated in both groups, and gradually declined as the patients recovered. However, postoperative levels of IL-10, CRP, and WBC were significantly lower in the SD (P < .05). The SD also showed significantly lower levels of malondialdehyde and higher levels of superoxide dismutase (P < .05). Postoperative levels of cortisol, adrenocorticotropic hormone, and norepinephrine were elevated and progressively returned to normal over time, and were significantly lower in the study group (P < .05). Furthermore, the SD experienced a significant reduction in adverse event incidence compared with the CG (P < .05). Implementing refined perioperative nursing interventions for patients undergoing URSL can effectively decrease the incidence of adverse events, diminish the surgical stimulation of inflammation markers and oxidative stress indicators, and foster patient recovery.

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