Biomass‐derived washable composites for accelerating the healing of infected wounds

Abstract

Advanced sustainable biomedical materials are urgently needed for clinical applications; however, developing biomedical materials with exceptional mechanical and bactericidal properties as well as removable functionalities to reduce unintended secondary injury remains a challenge. Here, we report a biomass‐derived composite consisting of water‐soluble fish gelatin (FG) and antibacterial ZnO@silk fibroin (ZSF) microspheres for potential application as the wound dressing. The ZSF microspheres are embedded in a FG matrix to realize the stretchable, antibacterial, and removable ZSF/FG composites. By introducing glycerin as the plasticizer, ZSF/FG composites deliver a tensile strength of 4.5 MPa and stretchability of 550%. Acting as both the germicide and hydrophile components, ZSF microspheres endow the composites with excellent antibacterial capacity and water solubility. To prevent secondary injury, the ZSF/FG composites can be easily removed from the wounds by simply exposing them to excess water. Additionally, the ZSF/FG composites exhibit favorable biocompatibility and sustain high cell viability of over 100%. The full‐thickness skin wound model on infected mice demonstrated an efficient rate of wound closure and a reduced inflammatory response. The ZSF/FG composite shows promise to hasten the healing of infected wounds and is expected a promising candidate as wound dressing for clinical therapy.

A Wearable Self-Charging Electroceutical Device for Bacteria-Infected Wound Healing

“…It may be attributed to electrical stimulation promoting M2 polarization of macrophages. This polarization inhibited the mitogen-activated protein kinase (MAPK) cascade and upregulated ATP synthesis and oxidative phosphorylation . These data further validate that ACZB neutralized the inflammatory milieu and promoted the polarization of macrophages toward an anti-inflammatory phenotype.…”

“…This polarization inhibited the mitogen-activated protein kinase (MAPK) cascade and upregulated ATP synthesis and oxidative phosphorylation. 53 These data further validate that ACZB neutralized the inflammatory milieu and promoted the polarization of macrophages toward an anti-inflammatory phenotype. In conclusion, the biological effects of ACZB have been confirmed through in vitro experiments.…”

Silicon Vacancies Diamond/Silk/PVA Hierarchical Physical Unclonable Functions for Multi‐Level Encryption

“…Preparation of SF/PVA Blends: SF aqueous solution and PVA aqueous solution were separately prepared as in the previous work. [46] Bombyx mori cocoons were first cut into small pieces and boiled in a 0.01 m Na 2 CO 3 solution for degumming. The resulting sediments were then washed three times with deionized water.…”