Biomaterial-based platforms for modulating immune components against cancer and cancer stem cells

Desai, Nimeet; Hasan, Uzma; Jeyashree, K; Mani, Rajesh; Chauhan, Meenakshi; Basu, Suparna Mercy; Giri, Jyotsnendu

doi:10.1016/j.actbio.2023.03.004

Cited by 21 publications

(4 citation statements)

References 241 publications

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“…In this regard, multicellular tumor spheroids or 3D cultures have been exponentially growing as these spheroids closely mimic the complexity and characteristics of solid tumors . To be classified as GSCs, the spheroids should be able to self-renew, differentiate into distinct lineages, generate neurosphere in vitro , and induce tumor formation in vivo . , Markers associated with GSCs include CD133, Nestin, CD44, CXCR4, A2B5, ALDH1A, and Sox2 . In this study, we checked the expression of two widely used markers, Nestin and ALDH1A1, which showed an increase in expression and corresponds to characteristics of GSCs.…”

Section: Results and Discussionmentioning

confidence: 99%

Reversal of Multidrug Resistance by the Synergistic Effect of Reversan and Hyperthermia to Potentiate the Chemotherapeutic Response of Doxorubicin in Glioblastoma and Glioblastoma Stem Cells

Hasan,

Rajakumara,

Giri

2023

ACS Appl. Bio Mater.

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The glioblastoma stem cell (GSC) population in glioblastoma multiforme (GBM) poses major complication in clinical oncology owing to increased resistance to chemotherapeutic drugs, thereby limiting treatment in patients with recurring glioblastoma. To completely eradicate glioblastoma, a single therapy module is not enough; therefore, there is a need to develop a multimodal approach to eliminate bulk tumors along with the CSC population. With an aim to target transporters associated with multidrug resistance (MDR), such as Pglycoprotein (P-gp), a small-molecule inhibitor, reversan (RV) was used along with multifunctional magnetic nanoparticles (MNPs) for hyperthermia (HT) therapy and targeted drug delivery. Higher efflux of free doxorubicin (Dox) from the cells was stabilized by encapsulation in PPS-MnFe nanoparticles, whose physicochemical properties were determined by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Treatment with RV also enhanced the cellular uptake of PPS-MnFe-Dox, whereas RV and magnetic hyperthermia (MHT) together showed prolonged retention of fluorescence dye, Rhodamine123 (R123), in glioblastoma cells compared with individual treatment. Overall, in this work, we demonstrated the synergistic action of RV and HT to combat MDR in GBM and GSCs, and chemo-hyperthermia therapy enhanced the cytotoxic effect of the chemotherapeutic drug Dox (with lower effective concentration) and induced a higher degree of apoptosis compared to single-drug dosage.

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Section: Results and Discussionmentioning

confidence: 99%

Reversal of Multidrug Resistance by the Synergistic Effect of Reversan and Hyperthermia to Potentiate the Chemotherapeutic Response of Doxorubicin in Glioblastoma and Glioblastoma Stem Cells

Hasan,

Rajakumara,

Giri

2023

ACS Appl. Bio Mater.

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“…In addition, β-glycerophosphate, which is a precursor for inorganic phosphate, has been shown to enhance mineralization by providing a source of phosphate ions for hydroxyapatite crystal formation Immunomodulatory factors: They modulate the activity of immune cells, such as macrophages, T cells, and regulatory T cells (Tregs), to promote a regenerative immune phenotype . They enhance the resolution of inflammation, promote the switch from pro-inflammatory (M1) to anti-inflammatory (M2) macrophage phenotypes, and promote the recruitment of immune cells that support tissue repair and regeneration. , Interleukin-10 (IL-10) is an anti-inflammatory cytokine that inhibits the production of pro-inflammatory cytokines and promotes tissue repair.…”

Section: Designing Nfmsmentioning

confidence: 99%

Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Desai,

Pande,

Vora

et al. 2024

ACS Appl. Bio Mater.

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Bone, a fundamental constituent of the human body, is a vital scaffold for support, protection, and locomotion, underscoring its pivotal role in maintaining skeletal integrity and overall functionality. However, factors such as trauma, disease, or aging can compromise bone structure, necessitating effective strategies for regeneration. Traditional approaches often lack biomimetic environments conducive to efficient tissue repair. Nanofibrous microspheres (NFMS) present a promising biomimetic platform for bone regeneration by mimicking the native extracellular matrix architecture. Through optimized fabrication techniques and the incorporation of active biomolecular components, NFMS can precisely replicate the nanostructure and biochemical cues essential for osteogenesis promotion. Furthermore, NFMS exhibit versatile properties, including tunable morphology, mechanical strength, and controlled release kinetics, augmenting their suitability for tailored bone tissue engineering applications. NFMS enhance cell recruitment, attachment, and proliferation, while promoting osteogenic differentiation and mineralization, thereby accelerating bone healing. This review highlights the pivotal role of NFMS in bone tissue engineering, elucidating their design principles and key attributes. By examining recent preclinical applications, we assess their current clinical status and discuss critical considerations for potential clinical translation. This review offers crucial insights for researchers at the intersection of biomaterials and tissue engineering, highlighting developments in this expanding field.

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“…Compared to traditional cancer treatments, immunotherapy is safer and more effective. Mainstream immunotherapy-based treatments include immune checkpoint blockers and CAR-T therapy, while cancer vaccines with molecular adjuvants are also being explored [ 202 ]. However, non-specific inflammation, autoimmune-like disorders, and severe toxicity-related disorders are critical drawbacks of immunotherapy.…”

Section: Theranostics Applicationsmentioning

confidence: 99%

“Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive Review

et al. 2023

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Achieving precise cancer theranostics necessitates the rational design of smart nanosystems that ensure high biological safety and minimize non-specific interactions with normal tissues. In this regard, “bioinspired” membrane-coated nanosystems have emerged as a promising approach, providing a versatile platform for the development of next-generation smart nanosystems. This review article presents an in-depth investigation into the potential of these nanosystems for targeted cancer theranostics, encompassing key aspects such as cell membrane sources, isolation techniques, nanoparticle core selection, approaches for coating nanoparticle cores with the cell membrane, and characterization methods. Moreover, this review underscores strategies employed to enhance the multi-functionality of these nanosystems, including lipid insertion, membrane hybridization, metabolic engineering, and genetic modification. Additionally, the applications of these bioinspired nanosystems in cancer diagnosis and therapeutics are discussed, along with the recent advances in this field. Through a comprehensive exploration of membrane-coated nanosystems, this review provides valuable insights into their potential for precise cancer theranostics.

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Biomaterial-based platforms for modulating immune components against cancer and cancer stem cells

Cited by 21 publications

References 241 publications

Reversal of Multidrug Resistance by the Synergistic Effect of Reversan and Hyperthermia to Potentiate the Chemotherapeutic Response of Doxorubicin in Glioblastoma and Glioblastoma Stem Cells

Reversal of Multidrug Resistance by the Synergistic Effect of Reversan and Hyperthermia to Potentiate the Chemotherapeutic Response of Doxorubicin in Glioblastoma and Glioblastoma Stem Cells

Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

“Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive Review

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