Biomaterials based on chitin and chitosan in wound dressing applications

Jayakumar, R.; Prabaharan, M.; Kumar, P.T. Sudheesh; Nair, Shantikumar V.; Tamura, Hiroshi

doi:10.1016/j.biotechadv.2011.01.005

Cited by 1,699 publications

(983 citation statements)

References 123 publications

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“…However ionic liquids based solvents allow effective dissolution and processing of chitin. It is now being used extensively in different forms, such as foams [13][14][15] , fibres 16,17 , gels [18][19][20] , micro particles 21 , nanoparticles [22][23][24] and nanofibers [25][26][27] , for a variety of biomedical applications [28][29][30] . Chitin is the second most abundant biopolymer after cellulose.…”

Section: Graphical Abstract 1 Introductionmentioning

confidence: 99%

Chitin and carbon nanotube composites as biocompatible scaffolds for neuron growth

et al. 2016

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Section: Graphical Abstract 1 Introductionmentioning

confidence: 99%

Chitin and carbon nanotube composites as biocompatible scaffolds for neuron growth

et al. 2016

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“…This may be attributed to the biochemical effects of chitosan in wound healing, which includes; increases the expression and activities of growth factors, fibroblast activation and stimulation of wound granulation and fibrous tissue synthesis (Abou El Ella et al, 2007;Muzzarelli, 2009;Jayakumar et al, 2011;Wang et al, 2012). In this study, the rate of wound contraction varied between different body areas; it was higher at the shoulder compared with the forearm.…”

Section: Discussionmentioning

confidence: 60%

Effect of Chitosan Gel on Wound Healing: Experimental Study in Donkeys

Anis¹,

Sharshar²,

Gaber³

et al. 2017

AJVS

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Key words:Chitosan gel, Donkeys, Histopathological changes, Wound healing Chitosan is one of the natural bioactive materials known for its wound healing effect. Healing of equine's wounds are often delayed and complicated. This study aimed to evaluate efficacy of chitosan gel on healing of equine skin-wounds in comparison to povidone-iodine (as control). Six adult male donkeys were used and divided equally into two groups; group A (2x2 cm skin-wound) and group B (4x4 cm skin-wound). Full thickness skin-wounds were created on forearms and shoulders. Wounds at the right side were irrigated using povidone-iodine, while wounds at the left side were dressed using chitosan gel. Clinically, chitosan treated wounds contracted faster than control wounds, and shoulder-wounds contracted faster than that of the forearm. By the end of the experiment all chitosan treated wounds were completely healed with intact epidermis. In contrast, 10.4 % and 13.3 % of wound's area treated with povidone-iodine in group B at the shoulder and the forearm regions, respectively, still unclosed. Grossly, povidoneiodine treated wounds in both regions, were covered with scab in group A, and had an area of granulation tissue in the wound-centers in group B. Chitosan treated wounds, in both groups in both regions, were completely covered with cornified epithelium. Microscopically, the re-epithelialization was uncompleted in povidone-iodine treated wounds in both groups in both regions. In contrary, complete epidermal layer was observed in wounds treated with chitosan in both groups in both regions. Finally, chitosan gel may be better than povidone-iodine in healing of equine skin wounds.

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“…Chitosan based nanofibers along with other natural polymer based nanofibers have recently attracted a great deal of attention to be used as wound dressing. Chitosan is most suitable for this application because it meets several requirements such as histocompatibility, biodegradability, lack of antigenicity and also promotes wound healing [89][90][91].…”

Section: Wound Dressingmentioning

confidence: 99%

Nanofibrous Structure of Chitosan for Biomedical Applications

Bhattarai¹

2012

J Nanomedic Biotherapeu Discover

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Biomaterials based on chitin and chitosan in wound dressing applications

Cited by 1,699 publications

References 123 publications

Chitin and carbon nanotube composites as biocompatible scaffolds for neuron growth

Chitin and carbon nanotube composites as biocompatible scaffolds for neuron growth

Effect of Chitosan Gel on Wound Healing: Experimental Study in Donkeys

Nanofibrous Structure of Chitosan for Biomedical Applications

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