Biomaterials based on freeze dried surface-deacetylated chitin nanofibers reinforced with sulfobutyl ether β-cyclodextrin gel in wound dressing applications

Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice

“…Owing to cationic electrostatic repulsive forces, the deacetylated chitin readily disintegrated and the SDACNFs were homogeneously dispersed in water. We have reported that SDACNFs have various biological activities, including effects on obesity and hypercholesterolemia by oral administration [14,15] and on wound healing by topical application [16,17]. In this study, we investigated the prophylactic effects of orally administered SDACNFs against 5-FU-induced intestinal mucositis.…”

Preparation of chitin-amphipathic anion/quaternary ammonium salt ecofriendly dressing and its effect on wound healing in mice

“…Therefore, the application of chitin quaternary ammonium salt in medicine has become more extensive than that of chitosan. 3,20 In addition, studies have reported the preparation of carboxymethyl chitosan octadecyl quaternary ammonium salt liposomes containing fat-soluble and water-soluble drugs by microemulsion method, which allow slow drug release. 21 As shown in Figure 2, compared to the conventional chitin structure in group A, a brush-like structure layer was visible under D1.…”

“…3 Studies have also suggested that with the increase of the ratio of drug and carrier, the drug loading increases; the reason is when the quality of microspheres under the same condition, the adsorption to the drug carrier within more than a certain adsorption time of microspheres after adding a saturated load of drugs, the encapsulation rate becomes smaller. 22 As shown in Figure 5, similar to what was observed for the release of drugs, the materials released faster in the first 24 h. 3,21 When B, C, or D group was cultured in PBS buffer solution, the chitin-amphipathic anion/quaternary ammonium salt was easily released to PBS through the chitin surface structure, resulting in an increase in release. 4,7,8 After 72 h, the amount released from chitin remained almost unchanged, indicating that the release had stabilized and reached its maximum, nearly 85%-90%.…”

“…2 For example, it can be used as components of medical biomaterials, such as absorbent surgical sutures, hemostatic agents, immune promoters, tumor inhibitors, and healing agents. 3,4 In their study on novel chitin/chitosan-glucan wound dressing, Abdel-Mohsen et al reported that novel nonwoven microfiber mats were fabricated by wet-dry spinning technique and evaluated the mechanical properties of fabrics mats and surface morphology. The novel chitin/chitosan-glucan complex(ChCsGC) nonwovens exhibited excellent surgical wound healing ability when tested using rat models.…”

Nanosilver coated Chitin derived membrane as an Eco-friendly Dressing and Its Effect on Wound Healing

“…However, there are regular ring structures and strong hydrogen bonds among chitin molecules, so that it has high crystallinity and poor solubility in water, dilute alkali, dilute acid and general organic solvents, which greatly limits its application [3,4]. To overcome these shortcomings, chitin can be quaternized ammonium salt, which is very important to its chemical modification [5,6].…”