Biomaterials Regulating Bone Microenvironment in Clinical Application

Zhang, Geng; Ren, Xiaoxiang; Wang, Sicheng

doi:10.1002/9783527837823.ch6

Cited by 1 publication

(2 citation statements)

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“…[135] Conventional treatments, such as bone grafts and implants, often have low success rates and can lead to complications, including infection, rejection, and a lack of integration with surrounding bone tissue. [136] In light of these issues, exosomes originating from MSCs have been demonstrated as a potential treatment, which can be selective in targeting cells involved in bone formation for promoting bone regeneration. [137] Lei et al found that healthy periodontal ligament stem cells (h-PDLSCs) that secrete exosomes were capable to rescue the osteogenic potential of stem cells in an inflammatory environment and promoting the regeneration of alveolar bone.…”

Section: Exosomes and Drug-loaded Exosomes For Targeted Treating Bone...mentioning

confidence: 99%

Section: Therapeutic Applications Of Bone‐targeted Exosomes In Bone‐r...mentioning

confidence: 99%

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Bone‐Targeted Exosomes: Strategies and Applications

Wang

Duan

Wang

et al. 2023

Adv Healthcare Materials

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As the global population ages, bone-related diseases have increasingly become a major social problem threatening human health. Exosomes, as natural cell products, have been used to treat bone-related diseases due to their superior biocompatibility, biological barrier penetration, and therapeutic effects. Moreover, the modified exosomes exhibit strong bone-targeting capabilities that may improve efficacy and avoid systemic side effects, demonstrating promising translational potential. However, a review of bone-targeted exosomes is still lacking. Thus, the recently developed exosomes for bone-targeting applications in this review are focused. The biogenesis and bone-targeting regulatory functions of exosomes, the constructive strategies of modified exosomes to improve bone-targeting, and their therapeutic effects for bone-related diseases are introduced. By summarizing developments and challenges in bone-targeted exosomes, It is striven to shed light on the selection of exosome constructive strategies for different bone diseases and highlight their translational potential for future clinical orthopedics.

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Section: Exosomes and Drug-loaded Exosomes For Targeted Treating Bone...mentioning

confidence: 99%

Section: Therapeutic Applications Of Bone‐targeted Exosomes In Bone‐r...mentioning

confidence: 99%