2022
DOI: 10.1016/j.spinee.2021.07.021
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Biomechanical changes in the lumbar spine following spaceflight and factors associated with postspaceflight disc herniation

Abstract: BACKGROUND CONTEXT: For chronic low back pain, the causal mechanisms between pathological features from imaging and patient symptoms are unclear. For instance, disc herniations can often be present without symptoms. There remains a need for improved knowledge of the pathophysiological mechanisms that explore spinal tissue damage and clinical manifestations of pain and disability. Spaceflight and astronaut health provides a rare opportunity to study potential low back pain mechanisms longitudinally. Spaceflight… Show more

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Cited by 22 publications
(35 citation statements)
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“…The current results support previous studies showing that a prolonged period of axial unloading induces lumbar spine deconditioning in healthy individuals ( Burkhart et al, 2019 ; Bailey et al, 2021 ). Greater amounts of PFC in lumbar musculature have been associated with high intensity of low back pain/disability in a community-based population ( Kjaer et al, 2007 ; Teichtahl et al, 2015 ), and a 16-week resistance training reduced PFC and improved quality of life ( Welch et al, 2015 ).…”
Section: Discussionsupporting
confidence: 92%
“…The current results support previous studies showing that a prolonged period of axial unloading induces lumbar spine deconditioning in healthy individuals ( Burkhart et al, 2019 ; Bailey et al, 2021 ). Greater amounts of PFC in lumbar musculature have been associated with high intensity of low back pain/disability in a community-based population ( Kjaer et al, 2007 ; Teichtahl et al, 2015 ), and a 16-week resistance training reduced PFC and improved quality of life ( Welch et al, 2015 ).…”
Section: Discussionsupporting
confidence: 92%
“…We used data from two studies previously described [ 11 , 12 ]. Dataset 1 contains features from lumbar MRI sequences.…”
Section: Methodsmentioning
confidence: 99%
“…Dataset 1 contains features from lumbar MRI sequences. Localizer images, sagittal and axial T2-weighted images, and sagittal T1-weighted images were acquired for 12 NASA astronauts taken before spending 6-months in prolonged microgravity at the International Space Station and after returning to Earth [ 11 , 13 , 14 ]. For this current study, we analyzed multifidus (MF), erector spinae (ES), quadratus lumborum (QL), and psoas (Ps) bilaterally at each spinal segment between L1-S1.…”
Section: Methodsmentioning
confidence: 99%
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