Biomechanical Properties and Cellular Responses in Pulmonary Fibrosis
Andong He,
Lizhe He,
Tianwei Chen
et al.
Abstract:Pulmonary fibrosis is a fatal lung disease affecting approximately 5 million people worldwide, with a 5-year survival rate of less than 50%. Currently, the only available treatments are palliative care and lung transplantation, as there is no curative drug for this condition. The disease involves the excessive synthesis of the extracellular matrix (ECM) due to alveolar epithelial cell damage, leading to scarring and stiffening of the lung tissue and ultimately causing respiratory failure. Although multiple fac… Show more
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