Biomechanical properties and dry weight content of the developing superficial digital flexor tendon in rabbit

Oryan, Ahmad; Shoushtari, A. H.

doi:10.1007/s00580-008-0764-9

Cited by 20 publications

(16 citation statements)

References 27 publications

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“…Collagen-elastin scaffolds may be valuable biomaterials for tissue engineering because they combine tensile strength with elasticity. Collagen and elastin networks contribute to highly specialized biomechanical responses in numerous tissues and species 76 . By incorporating reinforcing collagen microfibres, the recombinant elastomeric protein-based biomaterials can play a significant role in the loadbearing capacity of the substituted tissue.…”

Section: Cg Scaffoldsmentioning

confidence: 99%

Advances in injured tendon engineering with emphasis on the role of collagen implants

Oryan¹,

Moshiri²,

Sharifi³

2012

Hard Tissue

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IntroductionTendon injuries represent a significant clinical challenge to orthopaedic surgeons and investigators. Recently, many investigators claimed the beneficial effects of tissue engineering technologies in full-thickness tendon and ligament injuries both in vivo and in vitro. In this regard, several fabrication technologies with various types of biomaterials have been specially developed in recent years. In the present review, designing, fabrication and application of tissue-engineered products accentuating the role of collagen bioimplants in tendon tissue engineering is discussed. Conclusion Tissue engineering methods have not been able to differentiate the unimodal small-sized newly generated collagen fibrils from those of multi-modally differentiated fibrillar sizes of various diameters that are present in the normal tendons of a mature animal.

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Section: Cg Scaffoldsmentioning

confidence: 99%

Advances in injured tendon engineering with emphasis on the role of collagen implants

Oryan¹,

Moshiri²,

Sharifi³

2012

Hard Tissue

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“…The animals were weighed from day 0 (before injury) until 28 days post-injury (DPI) at week-ly intervals. Based on the methods of Oryan and Shoushtari [2009] and , the transverse diameter of the injured area (together with the overlying skin) of the tendons (left hind leg) and a comparable area of the control limb (right hind leg) were measured using an electronic digital caliper (Guanglu, Anyang, South Korea) before injury and then weekly until the end of the experiment. Each measurement was made three times to ensure that the repeatability of the tissue width measurements was within 0.2 mm.…”

Section: Measurements and Observations Before Euthanasiamentioning

confidence: 99%

Novel Application of Theranekron® Enhanced the Structural and Functional Performance of the Tenotomized Tendon in Rabbits

Oryan¹,

Moshiri

Raayat

2012

Cells Tissues Organs

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The effects of Tarantula cubensis extract (TC; Theranekron®) on the experimentally induced rupture of the superficial digital flexor tendon (SDFT) 28 days post-injury (DPI) was studied in rabbits. Forty mature White New Zealand male rabbits were randomly divided into two groups. TC was repeatedly injected subcutaneously over the lesion 3, 7 and 10 days after tenotomy and surgical anastomosis. Clinical and ultrasonographic evaluations were conducted at weekly intervals. The animals were euthanized 28 DPI and the tendons were investigated for macroscopic, histopathologic, ultrastructural, biomechanical and percent dry weight parameters. Treatment reduced signs of acute inflammation and strongly ameliorated clinical symptoms, structural organization and biomechanical properties (p < 0.05). Apparently, TC is effective in restoring the clinical, morphological and biomechanical properties of the injured SDFT in rabbits and may be valuable in human and veterinary medicine.

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“…For observation of the final outcome, it is also suggested to test the repaired tissue with different methodologies including both physical and chemical characteristics of the repaired tissue together with the morphological analysis at diffe rent levels (e.g. histopathology, ultra-structure) 65,66 .…”

mentioning

confidence: 99%

Role of tissue engineering in tendon reconstructive surgery and regenerative medicine: Current concepts, approaches and concerns

Moshiri¹,

Oryan²

2012

Hard Tissue

193

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Biomechanical properties and dry weight content of the developing superficial digital flexor tendon in rabbit

Cited by 20 publications

References 27 publications

Advances in injured tendon engineering with emphasis on the role of collagen implants

Advances in injured tendon engineering with emphasis on the role of collagen implants

Novel Application of Theranekron® Enhanced the Structural and Functional Performance of the Tenotomized Tendon in Rabbits

Role of tissue engineering in tendon reconstructive surgery and regenerative medicine: Current concepts, approaches and concerns

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