Biomechanical properties of ruptured versus electively repaired abdominal aortic aneurysm wall tissue

Martino, Elena S. Di; Bohra, Ajay; Geest, Jonathan P. Vande; Gupta, Navyash; Makaroun, Michel S.; Vorp, David A.

doi:10.1016/j.jvs.2005.10.072

Cited by 227 publications

(218 citation statements)

References 29 publications

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“…16,52 Di Martino et al have shown that the presence of ILT can significantly reduce wall stresses. [12][13][14][15] Fluid-structure interaction (FSI) simulations, in which a fully coupled dynamic interaction between the AAA hemodynamics and wall deformations is modeled, were conducted by our group and others to simulate the biomechanical behavior of the AAA wall. 3,14,18,36,48,60 Most previous FSI studies were based on isotropic material models that exclude the directional response of abdominal aortic tissue to stresses.…”

Section: Computational Simulations and Fluid-structure Interaction Momentioning

confidence: 99%

Patient-Based Abdominal Aortic Aneurysm Rupture Risk Prediction with Fluid Structure Interaction Modeling

et al. 2010

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Abstract-Elective repair of abdominal aortic aneurysm (AAA) is warranted when the risk of rupture exceeds that of surgery, and is mostly based on the AAA size as a crude rupture predictor. A methodology based on biomechanical considerations for a reliable patient-specific prediction of AAA risk of rupture is presented. Fluid-structure interaction (FSI) simulations conducted in models reconstructed from CT scans of patients who had contained ruptured AAA (rAAA) predicted the rupture location based on mapping of the stresses developing within the aneurysmal wall, additionally showing that a smaller rAAA presented a higher rupture risk. By providing refined means to estimate the risk of rupture, the methodology may have a major impact on diagnostics and treatment of AAA patients.

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Section: Computational Simulations and Fluid-structure Interaction Momentioning

confidence: 99%

Patient-Based Abdominal Aortic Aneurysm Rupture Risk Prediction with Fluid Structure Interaction Modeling

et al. 2010

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“…In computational simulations, vessel stress is calculated as a function of the vessel diameter [7,34], wall thickness [36,37], asymmetry [14,18,34,36], tortuosity [21], material property [17,24,29,38], calcification [15,22], intraluminal thrombus (ILT) [5,15,16,33], and blood flow [4, 9, 13, 14, 17, 20, 25, 26, 28-30, 32, 35-41]. Blood vessel strength is measured by ex vivo studies [11,12,23,31,44] or estimated by effective features such as ILT existence, sex, and genetic vulnerability [10]. Medical treatment techniques of aneurysms, mainly stent applications, are also investigated [35,40].…”

mentioning

confidence: 99%

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Şimşek

Kwon

2015

J Biol Phys

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Different material models for an idealized three-layered abdominal aorta are compared using computational techniques to study aneurysm initiation and fully developed aneurysms. The computational model includes fluid-structure interaction (FSI) between the blood vessel and the blood. In order to model aneurysm initiation, the medial region was degenerated to mimic the medial loss occurring in the inception of an aneurysm. Various cases are considered in order to understand their effects on the initiation of an abdominal aortic aneurysm. The layers of the blood vessel were modeled using either linear elastic materials or Mooney-Rivlin (otherwise known as hyperelastic) type materials. The degenerated medial region was also modeled in either linear elastic or hyperelastic-type materials and assumed to be in the shape of an arc with a thin width or a circular ring with different widths. The blood viscosity effect was also considered in the initiation mechanism. In addition, dynamic analysis of the blood vessel was performed without interaction with the blood flow by applying time-dependent pressure inside the lumen in a three-layered abdominal aorta. The stresses, strains, and displacements were compared for a healthy aorta, an initiated aneurysm and a fully developed aneurysm. The study shows that the material modeling of the vessel has a sizable effect on aneurysm initiation and fully developed aneurysms. Different material modeling of degeneration regions also affects the stressstrain response of aneurysm initiation. Additionally, the structural analysis without considering FSI (called noFSI) overestimates the peak von Mises stress by 52% at the interfaces of the layers.

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“…In addition, Di Martino et al [51] suggested a weak (but significant) negative correlation (R ¼ À0.42 and P ¼ 0.012) between the AAA wall thickness and its tensile strength. Using their patients' data, we regenerated the trend line estimating the linear relation between the AAA wall thickness (h in mm) and the AAA wall tensile strength (r u in kPa) such that r u ¼ À170:43h þ 1224:7.…”

Section: Discussionmentioning

confidence: 99%

“…We speculate that the inclusion of bending stiffness in our analysis intensifies the effects of spine contact on the morphology, wall stress distribution, and PWS, beyond what we observed in this study. Accurate measures of wall strength are yet to be considered in our analysis for a reliable assessment of rupture [50,51,57,58]. Our simulation cases represent hypothetical models of AAAs initiated by artificial elastin degradation in a healthy aorta instead of the real elastin loss in a patient's AAA wall.…”

Section: Discussionmentioning

confidence: 99%

Computational Growth and Remodeling of Abdominal Aortic Aneurysms Constrained by the Spine

Farsad

Zeinali‐Davarani

Choi

et al. 2015

Journal of Biomechanical Engineering

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Abdominal aortic aneurysms (AAAs) evolve over time, and the vertebral column, which acts as an external barrier, affects their biomechanical properties. Mechanical interaction between AAAs and the spine is believed to alter the geometry, wall stress distribution, and blood flow, although the degree of this interaction may depend on AAAs specific configurations. In this study, we use a growth and remodeling (G&R) model, which is able to trace alterations of the geometry, thus allowing us to computationally investigate the effect of the spine for progression of the AAA. Medical image-based geometry of an aorta is constructed along with the spine surface, which is incorporated into the computational model as a cloud of points. The G&R simulation is initiated by local elastin degradation with different spatial distributions. The AAA-spine interaction is accounted for using a penalty method when the AAA surface meets the spine surface. The simulation results show that, while the radial growth of the AAA wall is prevented on the posterior side due to the spine acting as a constraint, the AAA expands faster on the anterior side, leading to higher curvature and asymmetry in the AAA configuration compared to the simulation excluding the spine. Accordingly, the AAA wall stress increases on the lateral, posterolateral, and the shoulder regions of the anterior side due to the AAA-spine contact. In addition, more collagen is deposited on the regions with a maximum diameter. We show that an image-based computational G&R model not only enhances the prediction of the geometry, wall stress, and strength distributions of AAAs but also provides a framework to account for the interactions between an enlarging AAA and the spine for a better rupture potential assessment and management of AAA patients.

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Biomechanical properties of ruptured versus electively repaired abdominal aortic aneurysm wall tissue

Cited by 227 publications

References 29 publications

Patient-Based Abdominal Aortic Aneurysm Rupture Risk Prediction with Fluid Structure Interaction Modeling

Patient-Based Abdominal Aortic Aneurysm Rupture Risk Prediction with Fluid Structure Interaction Modeling

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Computational Growth and Remodeling of Abdominal Aortic Aneurysms Constrained by the Spine

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