Biomechanical study on implantable and interventional medical devices

Wang, Lizhen; Ding, Xia; Feng, Wentao; Gao, Yuanming; Zhao, Shudong; Fan, Yubo

doi:10.1007/s10409-021-01116-9

Cited by 31 publications

(12 citation statements)

References 179 publications

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“…Owning to the thermosensitive shape memory property of PGD, the scaffold possesses a cucumber tendril-like deformable structure that enables it to transform from a rod state at room temperature to a vortex-plate state after being implanted in the body. It is essential to design good mechanical properties of the scaffold to match with the native NP 15 , 25 . It is a benefit to delivery in surgery since PGD has a higher elastic modulus than elastoplastic at room temperature (Supplementary Fig.…”

Section: Discussionmentioning

confidence: 99%

“…A NP scaffold with mechanical support similar to native NP at restricted condition and minimal invasive ability is another potential approach we believe. It is necessary to develop an excellent degradable scaffold loaded SDF-1α with well-matched disc-supporting for tissue-engineered NP reconstruction 15 , 25 . The ideal tissue-engineered NP scaffold should meet characteristics including minimally invasive, disc-supporting, and viscoelastic properties matching with native NP 26 , 27 , and regeneration with biodegradation of scaffold.…”

Section: Introductionmentioning

confidence: 99%

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Innovative design of minimal invasive biodegradable poly(glycerol-dodecanoate) nucleus pulposus scaffold with function regeneration

Wang

Jin

et al. 2023

Nat Commun

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Minimally invasive biodegradable implants with regeneration have been a frontier trend in clinic. Degeneration of nucleus pulposus (NP) is irreversible in most of spine diseases, and traditional spinal fusion or discectomy usually injure adjacent segments. Here, an innovative minimally invasive biodegradable NP scaffold with function regeneration inspired by cucumber tendril is developed using shape memory polymer poly(glycerol-dodecanoate) (PGD), whose mechanical property is controlled to the similar with human NP by adjusting synthetic parameters. The chemokine stromal cell-derived factor-1α (SDF-1α) is immobilized to the scaffold recruiting autologous stem cells from peripheral tissue, which has better ability of maintaining disc height, recruiting autologous stem cells, and inducing regeneration of NP in vivo compared to PGD without chemokine group and hydrogel groups significantly. It provides an innovative way to design minimally invasive implants with biodegradation and functional recovery, especially for irreversible tissue injury, including NP, cartilage and so on.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Innovative design of minimal invasive biodegradable poly(glycerol-dodecanoate) nucleus pulposus scaffold with function regeneration

Wang

Jin

et al. 2023

Nat Commun

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“…Current studies are also focused on improving PGD’s cell adhesion, 3D/4D printability, and optical abilities. , It is garnering increasing attention in the field of biomedical engineering. For biodegradable polyester, there is an obvious difference between in vitro hydrolytic and in vivo degradation. − The in vivo degradation of biodegradable polyesters is affected by multiple factors, such as material properties, mechanical environments in the body, enzyme catalysis, and fibrous capsule encapsulation, which lead to differences in medical implant degradation durations. − The faster degradation of the implant material leads to insufficient mechanical support; the slower degradation also resists tissue remodeling …”

Section: Introductionmentioning

confidence: 99%

Biodegradation Behavior Control for Shape Memory Polyester Poly(Glycerol-Dodecanoate): An In Vivo and In Vitro Study

et al. 2023

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Poly(glycerol-dodecanoate) (PGD) has garnered increasing attention in biomedical engineering for its degradability, shape memory, and rubber-like mechanical properties. Adjustable degradation is important for biodegradable implants and is affected by various aspects, including material properties, mechanical environments, temperature, pH, and enzyme catalysis. The crosslinking and chain length characteristics of poly(lactic acid) and poly(caprolactone) have been widely used to adjust the in vivo degradation rate. The PGD degradation rate is affected by its crosslink density in in vitro hydrolysis; however, there is no difference in vivo. We believe that this phenomenon is caused by the differences in enzymatic conditions in vitro and in vivo. In this study, it is found that the degradation products of PGD with different molar ratios of hydroxyl and carboxyl (MRH/C) exhibit varied pH values, affecting the enzyme activity and thus achieving different degradation rates. The in vivo degradation of PGD is characterized by surface erosion, and its mass decreases linearly with degradation duration. The degradation duration of PGD is linearly extrapolated from 9–18 weeks when MRH/C is in the range of 2.00–0.75, providing a protocol for adjusting the degradation durations of subsequent implants made by PGD.

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“…43 Personalized biodegradable implants will be an irresistible trend in the clinic for implantable and interventional medical devices. 44 Some studies have shown that the processing method affects the mechanical properties of composite materials. 45 The melting temperature may improve the homogenization of the material.…”

Section: Introductionmentioning

confidence: 99%

Degradation behavior of polylactic‐co‐glycolic acid and polycaprolactone with nanosilver scaffolds

Dou,

Zhang,

Zhou

et al. 2023

J of Applied Polymer Sci

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Ureteral stents are commonly used in clinical treatment of ureteral diseases. There were a series of complications, such as biofilms and crusts caused by bacteria after surgery. Therefore, biodegradable with bacteriostatic ureteral scaffolds would be the potential to solve above mentioned problems. In this study, nanosilver (AgNP) was added to the polylactic‐co‐glycolic acid (PLGA) and polycaprolactone (PCL) to prepare biodegradable antibacterial ureteral scaffold samples by 3D printing. The biocompatibility, antibacterial properties, degradability, and mechanical properties of samples were observed. The samples were under a strong inhibitory effect on both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), and the higher the concentration of AgNP, the stronger the antibacterial effect. When the concentration of AgNP was 10%, the antibacterial effect was up to 100%. AgNP was released continually with the degradation of samples, which can achieve a continuous antibacterial effect. The breaking strength of the samples without and with AgNP were 6.08 ± 1.16 MPa and 26.02 ± 2.00 MPa. The mechanical properties of samples with AgNP were higher than those without AgNP. It provides a potential way to design ureteral scaffolds based on biodegradable polymers with AgNP in the clinic.

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Biomechanical study on implantable and interventional medical devices

Cited by 31 publications

References 179 publications

Innovative design of minimal invasive biodegradable poly(glycerol-dodecanoate) nucleus pulposus scaffold with function regeneration

Innovative design of minimal invasive biodegradable poly(glycerol-dodecanoate) nucleus pulposus scaffold with function regeneration

Biodegradation Behavior Control for Shape Memory Polyester Poly(Glycerol-Dodecanoate): An In Vivo and In Vitro Study

Degradation behavior of polylactic‐co‐glycolic acid and polycaprolactone with nanosilver scaffolds

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