Biomechanics and Spinal Modelling

Skalli, Wafa; Mitton, David; Rouch, Philippe; Dubousset, Jean

doi:10.1007/978-3-030-20925-4_32

Cited by 1 publication

(2 citation statements)

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“…In the case of a vertebra without metastasis, a sensitivity study has previously shown that a 1-cm anterior displacement of the loading on a vertebra would approximately decrease the vertebral strength by 50%. This highlights the influence of the postural alignment on the risk of fracture [124], and joins the observation of the highly increased and early incidence of vertebral fracture risk following a first fracture and the classic "vertebral fracture cascade". This also highlights the importance of preventing the first fracture.…”

Section: Tools To Assess Loadings Applied To Metastatic Bonessupporting

confidence: 66%

“…Static loadings due to the sagittal imbalance could be assessed from medical imaging. In particular, the low-dose EOS system [123] allows obtaining full-body radiographs in standing position to assess loadings on the spine and on specific vertebrae [124] (Figure 4). of bone metastases, the loadings of interest are those that reflect daily life movements.…”

Section: Tools To Assess Loadings Applied To Metastatic Bonesmentioning

confidence: 99%

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Fracture Risk Evaluation of Bone Metastases: A Burning Issue

Confavreux

Follet

Mitton

et al. 2021

Cancers

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Major progress has been achieved to treat cancer patients and survival has improved considerably, even for stage-IV bone metastatic patients. Locomotive health has become a crucial issue for patient autonomy and quality of life. The centerpiece of the reflection lies in the fracture risk evaluation of bone metastasis to guide physician decision regarding physical activity, antiresorptive agent prescription, and local intervention by radiotherapy, surgery, and interventional radiology. A key mandatory step, since bone metastases may be asymptomatic and disseminated throughout the skeleton, is to identify the bone metastasis location by cartography, especially within weight-bearing bones. For every location, the fracture risk evaluation relies on qualitative approaches using imagery and scores such as Mirels and spinal instability neoplastic score (SINS). This approach, however, has important limitations and there is a need to develop new tools for bone metastatic and myeloma fracture risk evaluation. Personalized numerical simulation qCT-based imaging constitutes one of these emerging tools to assess bone tumoral strength and estimate the femoral and vertebral fracture risk. The next generation of numerical simulation and artificial intelligence will take into account multiple loadings to integrate movement and obtain conditions even closer to real-life, in order to guide patient rehabilitation and activity within a personalized-medicine approach.

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Section: Tools To Assess Loadings Applied To Metastatic Bonessupporting

confidence: 66%

Section: Tools To Assess Loadings Applied To Metastatic Bonesmentioning

confidence: 99%