Biomedical 19F MRI Using Perfluorocarbons

Güden-Silber, Tuba; Temme, Sebastian; Jacoby, Christoph; Flögel, Ulrich

doi:10.1007/978-1-4939-7531-0_14

Cited by 9 publications

(5 citation statements)

References 17 publications

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“…The C−F bond is one of the strongest bonds in nature. This uniqueness allows for indestructible compounds where dense electron clouds block other chemicals, leading to superior chemical inertia, thermal stability, and hypotoxicity [41] . Of note, PFCs exhibit intrinsic hydrophobicity and lipophobicity, as well as low solubility, interfacial tension, and diffusivity; thus, molecular or pharmaceutical modifications are required to improve circulation of PFCs in the blood.…”

Section: F Mri Contrast Agentsmentioning

confidence: 99%

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects

Cui

et al. 2022

ChemMedChem

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Fluorine magnetic resonance imaging (19F MRI) is a promising imaging technique for cancer diagnosis because of its excellent soft tissue resolution and deep tissue penetration, as well as the inherent high natural abundance, almost no endogenous interference, quantitative analysis, and wide chemical shift range of the 19F nucleus. In recent years, scientists have synthesized various 19F MRI contrast agents. By further integrating a wide variety of nanomaterials and cutting‐edge construction strategies, magnetically equivalent 19F atoms are super‐loaded and maintain satisfactory relaxation efficiency to obtain high‐intensity 19F MRI signals. In this review, the nuclear magnetic resonance principle underlying 19F MRI is first described. Then, the construction and performance of various fluorinated contrast agents are summarized. Finally, challenges and future prospects regarding the clinical translation of 19F MRI nanoprobes are considered. This review will provide strategic guidance and panoramic expectations for designing new cancer theranostic regimens and realizing their clinical translation.

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Section: F Mri Contrast Agentsmentioning

confidence: 99%

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects

Cui

et al. 2022

ChemMedChem

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“…Overlaying 19 F and 1 H images provides detection and quantification of the 19 F-probe as "hot spots" in a specific site, while 1 H MRI depicts the anatomic context [423], allowing, for example, detection and localization of inflammation [424], or of venous thrombosis and diagnosis of pulmonary thromboembolism [425].…”

Section: Delivery or Removal Of Therapeutic Gases Other Than Oxygenmentioning

confidence: 99%

Therapeutic oxygen delivery by perfluorocarbon-based colloids

Krafft

Riess²

2021

Advances in Colloid and Interface Science

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“…Finally, an important advantage of OFCB over C 3 F 8 is magnetic equivalence of all fluorine nuclei in the molecule that results in a single‐signal spectrum. In contrast, the C 3 F 8 spectrum contains 2 signals originating from perfluorinated methyl and methylene groups, which may cause chemical shift artifacts and SNR loss without special techniques for spectrally selective excitation or detection 31 …”

Section: Discussionmentioning

confidence: 99%

¹⁹F MRI of human lungs at 0.5 Tesla using octafluorocyclobutane

Павлова

Анисимов

Gervits

et al. 2020

Magnetic Resonance in Med

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Purpose The aim of this study was to demonstrate the feasibility of fluorine‐19 (19F) MRI of the human lungs using octafluorocyclobutane (OFCB, C4F8). This gas has 8 magnetically equivalent fluorine nuclei and relatively long T1 and T2 (˜50 ms), which render it suitable as an MRI contrast agent. Previous experiments in small laboratory animals showed that OFCB could be successfully used as an alternative to the gases often used for 19F MRI (sulfur hexafluoride and perfluoropropane). Methods One male volunteer participated in this study. Immediately before an MRI scan, the volunteer inhaled the gas mixture—80% OFCB with 20% oxygen—and held his breath. Experiments were performed on a 0.5T whole‐body MR scanner with a customized transmit–receive coil tuned at 19F frequency. Fast spin echo in 2D and 3D modes was used for image acquisition. 2D images were obtained with in‐plane resolution of 10 × 10 mm2 without slice selection. 3D images were obtained with the voxel size of 10 × 10 × 30 mm2. Breath‐hold duration was 20 s for 2D and 40 s for 3D imaging, respectively. Results Anatomically consistent 19F MR images of the human lungs were obtained with SNR around 50 in 2D mode and 20 in 3D mode. 3D volumetric images of the lungs were reconstructed and provided physiologically reasonable volume estimates. Conclusion The application of OFCB enables informative 19F lung imaging even at low magnetic field strengths. The OFCB gas shows promise as an inhalable contrast agent for fluorine lung MRI and has a potential for clinical translation.

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Biomedical 19F MRI Using Perfluorocarbons

Cited by 9 publications

References 17 publications

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects

Therapeutic oxygen delivery by perfluorocarbon-based colloids

¹⁹F MRI of human lungs at 0.5 Tesla using octafluorocyclobutane

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Biomedical 19F MRI Using Perfluorocarbons

Cited by 9 publications

References 17 publications

19F MRI Nanotheranostics for Cancer Management: Progress and Prospects

19F MRI Nanotheranostics for Cancer Management: Progress and Prospects

Therapeutic oxygen delivery by perfluorocarbon-based colloids

19F MRI of human lungs at 0.5 Tesla using octafluorocyclobutane

Contact Info

Product

Resources

About

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects

¹⁹F MRI of human lungs at 0.5 Tesla using octafluorocyclobutane