Biomedical Applications of Polyhydroxyalkanoates

Lizarraga-Valderrama, Lorena R; Panchal, Bijal; Thomas, Carson H.; Boccaccını, Aldo R.; Roy, Ipsita

doi:10.1002/9781119126218.ch20

Cited by 15 publications

(20 citation statements)

References 132 publications

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“…Polyhydroxyalkanoates have also been widely studied for a range of biomedical applications especially in the field of tissue engineering and medical devices. Scl‐PHAs, such as P(3HB), P(4HB) and their copolymers have been used for hard tissue regeneration, such as bone tissue engineering or drug delivery systems, whereas mcl‐PHAs, such as P(3HO), have been applied for soft tissue regeneration, such as wound healing or cardiac tissue engineering (Lizarraga‐Valderrama et al ., ). The degradation products of PHAs are non‐acidic in nature and therefore do not evoke an inflammatory response.…”

Section: Introductionmentioning

confidence: 97%

Production of a novel medium chain length poly(3‐hydroxyalkanoate) using unprocessed biodiesel waste and its evaluation as a tissue engineering scaffold

Basnett

Lukasiewicz

Marcello

et al. 2017

Microbial Biotechnology

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SummaryThis study demonstrated the utilization of unprocessed biodiesel waste as a carbon feedstock for Pseudomonas mendocina CH50, for the production of PHAs. A PHA yield of 39.5% CDM was obtained using 5% (v/v) biodiesel waste substrate. Chemical analysis confirmed that the polymer produced was poly(3‐hydroxyhexanoate‐co‐3‐hydroxyoctanoate‐co‐3‐hydroxydecanoate‐co‐3‐hydroxydodecanoate) or P(3HHx‐3HO‐3HD‐3HDD). P(3HHx‐3HO‐3HD‐3HDD) was further characterized and evaluated for its use as a tissue engineering scaffold (TES). This study demonstrated that P(3HHx‐3HO‐3HD‐3HDD) was biocompatible with the C2C12 (myoblast) cell line. In fact, the % cell proliferation of C2C12 on the P(3HHx‐3HO‐3HD‐3HDD) scaffold was 72% higher than the standard tissue culture plastic confirming that this novel PHA was indeed a promising new material for soft tissue engineering.

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Section: Introductionmentioning

confidence: 97%

Production of a novel medium chain length poly(3‐hydroxyalkanoate) using unprocessed biodiesel waste and its evaluation as a tissue engineering scaffold

Basnett

Lukasiewicz

Marcello

et al. 2017

Microbial Biotechnology

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“…The wide range of properties is presented in Table 1 . The production of PHAs does not cause any harmful effects, hence is considered environmentally friendly to both organisms and the environment [ 7 ]. Furthermore, PHAs can be synthesised on a large-scale for sustainable development without causing any deleterious environmental impact.…”

Section: Polyhydroxyalkanoates (Phas)mentioning

confidence: 99%

“…One of the important properties of PHAs that has become the focus of polymer research is their biodegradability [ 7 , 25 ]. PHAs are degraded completely into CO 2 and H 2 O via natural microbiological mineralisation [ 14 ].…”

Section: Polyhydroxyalkanoates (Phas)mentioning

confidence: 99%

“…The mechanical properties of PHAs is to date is the most superior to be developed as biomaterials and are widely used in medical applications, especially tissue engineering [ 1 , 2 , 3 ]. Besides their biocompatibility, PHAs have attracted considerable interest due to their biodegradability, sustainability and thermo processability [ 4 , 5 , 6 ], and the degradation of PHAs do not cause tissue response in living organisms [ 7 ]. PHAs are generally produced by microorganisms as intracellular carbon and energy sources under excess carbon [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-co-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial

et al. 2020

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Polyhydroxyalkanoates (PHAs) are bacteria derived bio-based polymers that are synthesised under limited conditions of nutritional elements with excess carbon sources. Among the members of PHAs, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [(P(3HB-co-4HB)] emerges as an attractive biomaterial to be applied in medical applications owing to its desirable mechanical and physical properties, non-genotoxicity and biocompatibility eliciting appropriate host tissue responses. The tailorable physical and chemical properties and easy surface functionalisation of P(3HB-co-4HB) increase its practicality to be developed as functional medical substitutes. However, its applicability is sometimes limited due to its hydrophobic nature due to fewer bio-recognition sites. In this review, we demonstrate how surface modifications of PHAs, mainly P(3HB-co-4HB), will overcome these limitations and facilitate their use in diverse medical applications. The integration of nanotechnology has drastically enhanced the functionality of P(3HB-co-4HB) biomaterials for application in complex biological environments of the human body. The design of versatile P(3HB-co-4HB) materials with surface modifications promise a non-cytotoxic and biocompatible material without inducing severe inflammatory responses for enhanced effective alternatives in healthcare biotechnology. The enticing work carried out with P(3HB-co-4HB) promises to be one of the next-generation materials in biomedicines which will facilitate translation into the clinic in the future.

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“…Among the biodegradable polymers used to prepare these systems, those belonging to the polyhydroxyalkanoate family stand out, being also biocompatible. They are linear polyesters that have proven to be excellent candidates for medical and pharmaceutical applications (Lizarraga-Valderrama et al, 2016, Koller, 2018). In particular, a member of this family called poly(3-hydroxybutyrate) (PHB) is synthesized by bacterial fermentation (Vieyra et al, 2018) and, unlike other members of the polyhydroxyalkanoate family such as polyhydroxyvalerate and polyhydroxyhexanoate, is produced in large amounts by bacteria of different genus (El-Hadi et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Films based on the biopolymer poly(3-hydroxybutyrate) as platforms for the controlled release of dexamethasone

Villegas

Cid

Briones

et al. 2019

Saudi Pharmaceutical Journal

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Biomedical Applications of Polyhydroxyalkanoates

Cited by 15 publications

References 132 publications

Production of a novel medium chain length poly(3‐hydroxyalkanoate) using unprocessed biodiesel waste and its evaluation as a tissue engineering scaffold

Production of a novel medium chain length poly(3‐hydroxyalkanoate) using unprocessed biodiesel waste and its evaluation as a tissue engineering scaffold

Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-co-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial

Films based on the biopolymer poly(3-hydroxybutyrate) as platforms for the controlled release of dexamethasone

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