Biomimetic Accommodating Intraocular Lens Using a Valved Deformable Liquid Balloon

DeBoer, Charles; Lee, Jonathan K.; Wheelan, Brooks P.; Cable, Craig; Shi, Wendian; Tai, Yu‐Chong; Humayun, Mark S.

doi:10.1109/tbme.2015.2484379

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…Others seem to achieve an increased level of spectacle independence, but principally from pseudoaccommodative mechanisms such as multifocality, rather than a change in optical power (Pepose et al, 2017a). Newer designs (few that have been clinically tested) include dual optics, shape changing optics and refractive index changing optics (Ben-Nun and DeBoer et al, 2016;McCafferty and Schwiegerling, 2015;Tomas-Juan and Murueta-Goyena Larranaga, 2015). The latter research on possible future advances in 'accommodating' implants is discussed in section 7.…”

Section: 'Accommodating' Iolsmentioning

confidence: 99%

Presbyopia: Effectiveness of correction strategies

Wolffsohn

Davies

2019

Progress in Retinal and Eye Research

231

178

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Presbyopia is a global problem affecting over a billion people worldwide. The prevalence of unmanaged presbyopia is as high as 50% of those over 50 years of age in developing world populations, due to a lack of awareness and accessibility to affordable treatment, and is even as high as 34% in developed countries. Definitions of presbyopia are inconsistent and varied, so we propose a redefinition that states "presbyopia occurs when the physiologically normal age-related reduction in the eye's focusing range reaches a point, when optimally corrected for distance vision, that the clarity of vision at near is insufficient to satisfy an individual's requirements". Strategies for correcting presbyopia include separate optical devices located in front of the visual system (reading glasses) or a change in the direction of gaze to view through optical zones of different optical powers (bifocal, trifocal or progressive addition spectacle lenses), monovision (with contact lenses, intraocular lenses, laser refractive surgery and corneal collagen shrinkage), simultaneous images (with contact lenses, intraocular lenses and corneal inlays), pinhole depth of focus expansion (with intraocular lenses, corneal inlays and pharmaceuticals), crystalline lens softening (with lasers or pharmaceuticals) or restored dynamics (with 'accommodating' intraocular lenses, scleral expansion techniques and ciliary muscle electrostimulation); these strategies may be applied differently to the two eyes to optimise the range of clear focus for an individual's task requirements and minimise adverse visual effects. However, none fully overcome presbyopia in all patients. While the restoration of natural accommodation or an equivalent remains elusive, guidance is given on presbyopic correction evaluation techniques.

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Section: 'Accommodating' Iolsmentioning

confidence: 99%

Presbyopia: Effectiveness of correction strategies

Wolffsohn

Davies

2019

Progress in Retinal and Eye Research

231

178

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“…Currently, we are using a gel lens; however, it is not soft enough. Several researchers (DeBoer et al [ 17 ]) suggest using a deformable liquid balloon lens, which is softer than a gel lens. However, if a softer lens is used, there could be a relatively greater problem related to astigmatism.…”

Section: Resultsmentioning

confidence: 99%

Artificial accommodating intraocular lens powered by an ion polymer-metal composite actuator

et al. 2021

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The current method of controlling the focus of an accommodating intraocular lens is based on ciliary muscle contraction and cannot be used in older patients with presbyopia. We aimed to develop a dynamically accommodating intraocular lens powered by a membrane-shaped ion polymer metal composite actuator that is thin enough to be inserted in the eye. This study addresses two key problems identified in our previous accommodating intraocular lens prototype: the lack of repeatability due to the use of swine lenses instead of artificial lenses and the occurrence of a sixth order aberration. Thus, we present a new accommodating intraocular lens design and a method to transfer energy to actuators. To accommodate lens deformation and depth of focus, we used a membrane-shaped ion polymer metal composite actuator, thin enough to be inserted in the eye, and used an artificial silicone lens. To prevent the sixth order aberration, we included a ring between the ion polymer metal composite actuator and the lens. Different voltage patterns were applied to the IPMC actuator and changes in focus were observed. We were able to obtain repeatability and prevent the sixth order aberration. The dioptric power changed to ±0.23 D when ±1.5 V was used; however, at >1.5 V, a large accommodating range occurred, in addition to astigmatic vision. Thus, we have developed a novel prototype that is completely artificial, allowing reproducible and repeatable results. Visual accommodative demands were successfully met; however, although astigmatic vision was lessened, it was not completely eradicated.

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“…In this way, the liquid IOL could obtain the ability to alter the shape, thus processing the effect of adjusting the refractive power, which was also called accommodation IOL. The relative research in this area is brought by Deboer et al (2015) . They introduced a deformable PDMS lens shell filled with a transparent liquid.…”

Section: Advances In Intraocular Lens Optical Materialsmentioning

confidence: 99%

Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery

Luo

Wang

Chen

et al. 2022

Front. Bioeng. Biotechnol.

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Advances in cataract surgery have increased the demand for intraocular lens (IOL) materials. At present, the progress of IOL materials mainly contains further improving biocompatibility, providing better visual quality and adjustable ability, reducing surgical incision, as well as dealing with complications such as posterior capsular opacification (PCO) and ophthalmitis. The purpose of this review is to describe the research progress of relevant IOL materials classified according to different clinical purposes. The innovation of IOL materials is often based on the common IOL materials on the market, such as silicon and acrylate. Special properties and functions are obtained by adding extra polymers or surface modification. Most of these studies have not yet been commercialized, which requires a large number of clinical trials. But they provide valuable thoughts for the optimization of the IOL function.

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Biomimetic Accommodating Intraocular Lens Using a Valved Deformable Liquid Balloon

Abstract: A deformable liquid-filled lens can significantly improve accommodation over the presbyopic natural lens.

Cited by 9 publications

References 25 publications

Presbyopia: Effectiveness of correction strategies

Presbyopia: Effectiveness of correction strategies

Artificial accommodating intraocular lens powered by an ion polymer-metal composite actuator

Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery

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