Biomimetic and electrolytic calcium phosphate coatings on titanium alloy: physicochemical characteristics and cell attachment

Wang, Jiawei; Layrolle, Pierre; Stigter, M.; Groot, K. de

doi:10.1016/s0142-9612(03)00559-3

Cited by 163 publications

(140 citation statements)

References 28 publications

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“…The globules appear to consist of small spherical crystals, approximately 1-2 m in diameter. The resultant surface confirms the success of biomimetic carbonate apatite coating of Ti-6Al-4V [33,34]. A subsequent heat treatment dehydrates this hydrogel layer and stabilizes it by the formation of an amorphous sodium titanate layer (HTiO 3 Na), [37].…”

Section: C-sbf Samplessupporting

confidence: 56%

Biomimetic Coating of Precalcified Ti-6Al-4V Alloy

Adawy¹,

Abdel-Fattah²,

El-Sayed³

et al. 2009

TOMDJ

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Calcium hydroxyapatite, HA, (Ca 10 (PO 4 ) 6 (OH) 2 ) bioceramics, owing to their similarity with the human bone and dentin minerals, attract significant interest for orthopaedic and dental applications. Biological apatites, on the other hand, are carbonate substituted and calcium-deficient. Biomimetic coating of titanium and related alloys with carbonated apatitic calcium phosphate is an important area of research in implantology. While this paper specifically refers to coating Ti-6Al-4V, (TAV) the obtained results are valid with other related alloys as well.An attempt was made in the current research to accelerate the biomimetic coating process through precalcification of the alkali and heat treated alloy. The precalcification resulted in a homogenous layer of calcium precursors on the surface of the alloys. Such precursors accelerated the biomimetic deposition of carbonate hydroxyapatite (CHA) coat resembling that of the biomineral apatite upon soaking in Kukubo corrected simulated body fluid (1.5 c-SBF). The development of coats on Ti-6Al-4V surfaces were assessed by step by step diffuse reflectance infra-red spectroscopy and scanning electron microscopy.The essential information of biodeposition was obtained by following the uptake or release of calcium and inorganic phosphorus, Ca, iP, ionic species biochemically and mirrored by parallel electrical conductivity measurements of the soaking solutions.

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Section: C-sbf Samplessupporting

confidence: 56%

Biomimetic Coating of Precalcified Ti-6Al-4V Alloy

Adawy¹,

Abdel-Fattah²,

El-Sayed³

et al. 2009

TOMDJ

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“…The titanium implants have been proven biocompatible with osteoblasts, chondrocytes, and stromal cells in in vitro studies [7,[35][36][37]. Enhancement of the interface between the implants and cells has been attempted by creating open pores on the implant surface [38], making fiber metal composites [39], and treating the surface of the implants with calcium phosphates [40][41] by varying thermal conditions [42].…”

Section: Discussionmentioning

confidence: 99%

Porous composite prosthetic pylon for integration with skin and bone

Pitkin¹,

Raykhtsaum²,

Pilling³

et al. 2007

JRRD

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Abstract-This article presents results of the further development and testing of the "skin and bone integrated pylon" (SBIP-1) for percutaneous (through skin) connection of the residual bone with an external limb prosthesis. We investigated a composite structure (called the SBIP-2) made of titanium particles and fine wires using mathematical modeling and mechanical testing. Results showed that the strength of the pylon was comparable with that of anatomical bone. In vitro and in vivo animal studies on 30 rats showed that the reinforcement of the composite pylon did not compromise its previously shown capacity for inviting skin and bone cell ingrowth through the device. These findings provide evidence for the safe and reliable long-term percutaneous transfer of vital and therapeutic substances, signals, and necessary forces and moments from a prosthetic device to the body.

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“…Zhang et al (2009) reported that plate-like HA formed in cases where CN was used as the calcium stock solution. There are a few CPCs, e.g., octacalcium phosphate (Wang et al, 2004) and DCP (dicalcium phosphate) (Toyama et al, 2001), whose precipitation leads to plate-like crystals. Non-HA CPC ultimately changes into HA (Tung, 1998).…”

Section: Compressive Strength Imparted By Cpcmentioning

confidence: 99%

Novel grout material comprised of calcium phosphate compounds: In vitro evaluation of crystal precipitation and strength reinforcement

Akiyama¹,

Kawasaki

2012

Engineering Geology

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Calcium phosphate compounds (CPCs) have unique physicochemical properties. As grout material, they afford many advantages such as adequate physical strength, self-setting property, pH dependence of precipitation, non-toxicity, and recyclability. To apply CPCs to the permeability control and reinforcement of ground soil and rock, we explored suitable conditions for in vitro CPC precipitation, conducted unconfined compressive strength (UCS) tests of Toyoura sand test pieces cemented by CPC, and carried out observations and elemental analysis of precipitated CPC crystals.Two kinds of phosphate stock solution and two kinds of calcium stock solution were used to prepare the reaction mixtures, and CPC precipitation was detected in all reaction mixtures. The volume of CPC precipitation in the reaction mixture increased as the pH rose from strongly acidic to around neutral. The UCS of Toyoura sand test pieces cemented by 1.5 M diammonium phosphate and 0.75 M calcium acetate tended to increase with time, reaching a maximum of 63.5 kPa after 14 days of curing. Conversely, the UCS of test pieces cemented by using calcium nitrate was below 20 kPa and showed no significant increase in strength. CPC precipitation with calcium nitrate induced the formation of plate-like crystals, whereas that with calcium acetate induced whisker-like crystals.Elemental analysis of the cemented test pieces showed that the distributions of phosphorus and calcium were similar. The results indicate the practical feasibility of using novel CPC grouts as chemical grouts because of their self-setting property, and as biogrouts because of their crystal 3 structure and pH dependence of precipitation.

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Biomimetic and electrolytic calcium phosphate coatings on titanium alloy: physicochemical characteristics and cell attachment

Cited by 163 publications

References 28 publications

Biomimetic Coating of Precalcified Ti-6Al-4V Alloy

Biomimetic Coating of Precalcified Ti-6Al-4V Alloy

Porous composite prosthetic pylon for integration with skin and bone

Novel grout material comprised of calcium phosphate compounds: In vitro evaluation of crystal precipitation and strength reinforcement

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